Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| adipocyte | 8 studies | 32% ± 4% | |
| fibroblast | 4 studies | 25% ± 5% | |
| luminal hormone-sensing cell of mammary gland | 4 studies | 36% ± 12% | |
| hepatocyte | 4 studies | 52% ± 17% | |
| glomerular endothelial cell | 3 studies | 22% ± 4% | |
| cardiac muscle cell | 3 studies | 17% ± 1% | |
| GABAergic neuron | 3 studies | 31% ± 13% |
Insufficient scRNA-seq data for expression of AR at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 6911.07 | 245 / 245 | 100% | 59.28 | 502 / 502 |
| breast | 100% | 4052.58 | 458 / 459 | 84% | 57.02 | 936 / 1118 |
| liver | 100% | 6489.36 | 226 / 226 | 72% | 15.93 | 292 / 406 |
| kidney | 91% | 939.99 | 81 / 89 | 78% | 13.92 | 706 / 901 |
| ovary | 100% | 4512.69 | 180 / 180 | 67% | 13.61 | 286 / 430 |
| uterus | 100% | 7414.18 | 170 / 170 | 23% | 5.23 | 104 / 459 |
| bladder | 95% | 1923.33 | 20 / 21 | 21% | 2.74 | 104 / 504 |
| thymus | 95% | 1284.59 | 622 / 653 | 15% | 1.72 | 93 / 605 |
| skin | 99% | 2372.92 | 1785 / 1809 | 3% | 0.22 | 14 / 472 |
| blood vessel | 100% | 2889.86 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 1814.29 | 797 / 803 | 0% | 0 | 0 / 0 |
| adipose | 99% | 2774.59 | 1190 / 1204 | 0% | 0 | 0 / 0 |
| lung | 89% | 769.33 | 515 / 578 | 8% | 0.84 | 90 / 1155 |
| heart | 92% | 1614.64 | 789 / 861 | 0% | 0 | 0 / 0 |
| esophagus | 77% | 753.03 | 1113 / 1445 | 1% | 0.10 | 2 / 183 |
| adrenal gland | 59% | 442.70 | 152 / 258 | 13% | 1.90 | 30 / 230 |
| intestine | 67% | 733.12 | 644 / 966 | 2% | 0.22 | 13 / 527 |
| stomach | 64% | 593.69 | 229 / 359 | 2% | 0.16 | 6 / 286 |
| brain | 14% | 99.60 | 381 / 2642 | 50% | 5.55 | 351 / 705 |
| spleen | 27% | 184.26 | 66 / 241 | 0% | 0 | 0 / 0 |
| pancreas | 13% | 78.03 | 44 / 328 | 12% | 1.00 | 22 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 9% | 1.35 | 4 / 45 |
| peripheral blood | 0% | 0.46 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006366 | Biological process | transcription by RNA polymerase II |
| GO_0060599 | Biological process | lateral sprouting involved in mammary gland duct morphogenesis |
| GO_0048009 | Biological process | insulin-like growth factor receptor signaling pathway |
| GO_0060571 | Biological process | morphogenesis of an epithelial fold |
| GO_0035264 | Biological process | multicellular organism growth |
| GO_0033148 | Biological process | positive regulation of intracellular estrogen receptor signaling pathway |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0060748 | Biological process | tertiary branching involved in mammary gland duct morphogenesis |
| GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
| GO_0060769 | Biological process | positive regulation of epithelial cell proliferation involved in prostate gland development |
| GO_1902895 | Biological process | positive regulation of miRNA transcription |
| GO_0060520 | Biological process | activation of prostate induction by androgen receptor signaling pathway |
| GO_0019102 | Biological process | male somatic sex determination |
| GO_0050673 | Biological process | epithelial cell proliferation |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0045726 | Biological process | positive regulation of integrin biosynthetic process |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0045720 | Biological process | negative regulation of integrin biosynthetic process |
| GO_0000165 | Biological process | MAPK cascade |
| GO_0007165 | Biological process | signal transduction |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0071383 | Biological process | cellular response to steroid hormone stimulus |
| GO_0048808 | Biological process | male genitalia morphogenesis |
| GO_0003382 | Biological process | epithelial cell morphogenesis |
| GO_0060736 | Biological process | prostate gland growth |
| GO_0072520 | Biological process | seminiferous tubule development |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0060740 | Biological process | prostate gland epithelium morphogenesis |
| GO_0043568 | Biological process | positive regulation of insulin-like growth factor receptor signaling pathway |
| GO_0033327 | Biological process | Leydig cell differentiation |
| GO_1903076 | Biological process | regulation of protein localization to plasma membrane |
| GO_0030521 | Biological process | androgen receptor signaling pathway |
| GO_0042327 | Biological process | positive regulation of phosphorylation |
| GO_0140694 | Biological process | non-membrane-bounded organelle assembly |
| GO_0060742 | Biological process | epithelial cell differentiation involved in prostate gland development |
| GO_0071391 | Biological process | cellular response to estrogen stimulus |
| GO_0030522 | Biological process | intracellular receptor signaling pathway |
| GO_0048645 | Biological process | animal organ formation |
| GO_0060749 | Biological process | mammary gland alveolus development |
| GO_0071394 | Biological process | cellular response to testosterone stimulus |
| GO_0045597 | Biological process | positive regulation of cell differentiation |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0008584 | Biological process | male gonad development |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0007338 | Biological process | single fertilization |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0007283 | Biological process | spermatogenesis |
| GO_0030518 | Biological process | nuclear receptor-mediated steroid hormone signaling pathway |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0050680 | Biological process | negative regulation of epithelial cell proliferation |
| GO_0003073 | Biological process | regulation of systemic arterial blood pressure |
| GO_0045945 | Biological process | positive regulation of transcription by RNA polymerase III |
| GO_0048638 | Biological process | regulation of developmental growth |
| GO_2001237 | Biological process | negative regulation of extrinsic apoptotic signaling pathway |
| GO_0030520 | Biological process | estrogen receptor signaling pathway |
| GO_0005634 | Cellular component | nucleus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0016607 | Cellular component | nuclear speck |
| GO_0005829 | Cellular component | cytosol |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0034056 | Molecular function | estrogen response element binding |
| GO_0001223 | Molecular function | transcription coactivator binding |
| GO_0140693 | Molecular function | molecular condensate scaffold activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0051117 | Molecular function | ATPase binding |
| GO_0070974 | Molecular function | POU domain binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001091 | Molecular function | RNA polymerase II general transcription initiation factor binding |
| GO_0060090 | Molecular function | molecular adaptor activity |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0005496 | Molecular function | steroid binding |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0004930 | Molecular function | G protein-coupled receptor activity |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_0004879 | Molecular function | nuclear receptor activity |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0008013 | Molecular function | beta-catenin binding |
| GO_0005497 | Molecular function | androgen binding |
| Gene name | AR |
| Protein name | AR protein Androgen receptor splice variant 5 Androgen receptor splice variant 6 Androgen receptor variant 5,6,7es Mutant androgen receptor isoform 1 transcript variant 1 Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) Androgen receptor Androgen receptor splice variant 4b |
| Synonyms | DHTR NR3C4 |
| Description | FUNCTION: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues . Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation . Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. .; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. .; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. . FUNCTION: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. . FUNCTION: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. . FUNCTION: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. . |
| Accessions | D3YPQ3 E9PEG3 A0A6H0MAB3 ENST00000612452.5 [P10275-1] ENST00000374690.9 [P10275-1] D3YPP9 ENST00000504326.5 [P10275-3] ENST00000396044.8 P10275 D2Y6K2 A0A6H0MAE6 A0A087X1B6 A0A7I2PS51 ENST00000612452 D5M8Q2 C0JKD6 C0JKD5 Q9UKJ6 D3YPQ0 ENST00000613054.2 A0A3G2C3P2 D3YPQ1 ENST00000396043.4 A0A087WUX9 Q13771 D2KF13 D3YPQ2 V9TLK5 ENST00000514029.5 X5DNC5 C0JKD7 F5GZG9 V9GZH8 |
