Interactors | Protein name | Directionality | Classification | |
|---|---|---|---|---|
| 1 | CCL3-CCR5 | CCL3_HUMAN - CCR5_HUMAN | Ligand-Receptor | Signaling by Chemokines |
| 2 | EPGN-EGFR | EPGN_HUMAN - EGFR_HUMAN | Ligand-Receptor | Signaling by Epidermal growth factor |
| 3 | FGF8-FGFR3 | FGF8_HUMAN - FGFR3_HUMAN | Ligand-Receptor | Signaling by Fibroblast growth factor |
| 4 | NRTN-GFRA2+RET | NRTN_HUMAN - | Ligand-Receptor | Signaling by Neurotrophin |
| Name | MAPK cascade |
| ID | GO_0000165 |
| collection_id | Biological process |
| Alternative ID | GO:0007255 |
| Exact synonym | MAP kinase cascade, MAP kinase kinase kinase cascade, MAPK signal transduction, MAPKKK cascade, mitogen-activated protein kinase cascade |
| Description | An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| Related synonym | MAPK signaling, MAPK signalling |
| Comment | MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier. |
| External URL | |
| Genes | YWHAENENFDUSP9KSR2SHANK3KSR1MAPK8IP3MEF2AKRASSPAG9PRKCEAKAP13DUSP19SBK2DUSP6CCL3MAP3K11BRAFMBPPPP1CBMAPK7MAP3K14RETMYCITPKBMAP4K5TNIKMAPK15PTPN3MAPKAPK5MAP3K15CAMKK2FGFR1MAP3K4MAP3K20POU4F2ARZDHHC9MAPK4HSF1STUB1CD36FGF13ADRA2BUSP17L2MAPK3SH3RF1MAP3K3MAP2K5CCR5PABPN1IL31RAEGFRZFP36SCG2ARAFPPP1CCPAK3ASH1LMAPK12RAPGEF2RASGRP3TAOK3RHBDD3MAP3K1PTPRCSMAD1MAP2K1MAPKAPK2PPP5CCAV3MAP3K5IGFBP3MAP2K4MAP2K2PPM1LMAP3K9DUSP5MAP2K3NPR2SORBS3RAF1MEF2CMAP3K8MAPKAPK3FGF8PTK2BLRRK2MAP3K6ADRA1AMAP4K4RCE1BRAPRIT2MEN1PAK1NF1RBX1NRASMAP3K21MAP3K7NLKIQGAP1MAP2K6FGFR3RIPK1P2RX7PLVAPNRTNPTPN6MAP3K2EPGNDUSP7CTNNB1NF2BANK1PTPN7CAV1ZFP36L1HRASMOSIGFBP4PEA15MINK1MAPK6 |