I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 52% ± 7% | |
| GABAergic neuron | 3 studies | 45% ± 6% | |
| interneuron | 3 studies | 39% ± 18% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 52% ± 7% | |
| GABAergic neuron | 3 studies | 45% ± 6% | |
| interneuron | 3 studies | 39% ± 18% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 36% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 1638.27 | 89 / 89 | 96% | 11.03 | 866 / 901 |
| pancreas | 100% | 2359.50 | 328 / 328 | 93% | 7.72 | 166 / 178 |
| lung | 94% | 528.15 | 544 / 578 | 96% | 8.89 | 1113 / 1155 |
| stomach | 77% | 1660.80 | 278 / 359 | 98% | 12.26 | 279 / 286 |
| adrenal gland | 100% | 597.06 | 257 / 258 | 73% | 5.33 | 167 / 230 |
| thymus | 100% | 427.54 | 650 / 653 | 70% | 3.01 | 426 / 605 |
| prostate | 85% | 257.54 | 208 / 245 | 75% | 3.14 | 374 / 502 |
| ovary | 61% | 127.22 | 110 / 180 | 97% | 9.99 | 415 / 430 |
| liver | 100% | 574.89 | 226 / 226 | 52% | 4.93 | 212 / 406 |
| intestine | 52% | 568.65 | 506 / 966 | 99% | 11.76 | 521 / 527 |
| esophagus | 40% | 182.03 | 580 / 1445 | 99% | 15.37 | 181 / 183 |
| uterus | 47% | 111.26 | 80 / 170 | 81% | 6.11 | 374 / 459 |
| breast | 59% | 238.32 | 270 / 459 | 59% | 4.03 | 661 / 1118 |
| bladder | 33% | 112.81 | 7 / 21 | 74% | 5.35 | 371 / 504 |
| skin | 80% | 447.74 | 1447 / 1809 | 4% | 0.15 | 20 / 472 |
| brain | 79% | 564.77 | 2096 / 2642 | 4% | 0.13 | 25 / 705 |
| tonsil | 0% | 0 | 0 / 0 | 78% | 4.86 | 35 / 45 |
| spleen | 39% | 63.67 | 95 / 241 | 0% | 0 | 0 / 0 |
| adipose | 32% | 67.05 | 386 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 31% | 1.85 | 9 / 29 |
| blood vessel | 19% | 30.87 | 254 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 6% | 10.94 | 60 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 5% | 0.12 | 4 / 80 |
| heart | 3% | 4.99 | 29 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007165 | Biological process | signal transduction |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0000165 | Biological process | MAPK cascade |
| GO_0005575 | Cellular component | cellular_component |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0004706 | Molecular function | JUN kinase kinase kinase activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0004672 | Molecular function | protein kinase activity |
| Gene name | MAP3K21 |
| Protein name | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) |
| Synonyms | KIAA1804 MLK4 |
| Description | FUNCTION: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. . |
| Accessions | ENST00000366623.7 [Q5TCX8-2] ENST00000366622.1 [Q5TCX8-3] Q5TCX8 ENST00000366624.8 [Q5TCX8-1] |
