ASH1L | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	41 studies	40% ± 18%	Explore
fibroblast	37 studies	34% ± 17%	Explore
B cell	34 studies	27% ± 12%	Explore
pericyte	29 studies	34% ± 16%	Explore
smooth muscle cell	26 studies	33% ± 13%	Explore
macrophage	23 studies	37% ± 21%	Explore
natural killer cell	23 studies	25% ± 10%	Explore
CD4-positive, alpha-beta T cell	23 studies	24% ± 9%	Explore
CD8-positive, alpha-beta T cell	22 studies	23% ± 8%	Explore
astrocyte	21 studies	50% ± 19%	Explore
T cell	20 studies	30% ± 13%	Explore
regulatory T cell	20 studies	25% ± 9%	Explore
mast cell	18 studies	31% ± 14%	Explore
naive B cell	17 studies	24% ± 6%	Explore
microglial cell	17 studies	53% ± 17%	Explore
memory B cell	17 studies	22% ± 5%	Explore
endothelial cell of lymphatic vessel	16 studies	35% ± 18%	Explore
oligodendrocyte	16 studies	54% ± 17%	Explore
oligodendrocyte precursor cell	16 studies	49% ± 20%	Explore
basal cell	15 studies	37% ± 19%	Explore
ciliated cell	14 studies	31% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	26% ± 9%	Explore
glutamatergic neuron	13 studies	63% ± 23%	Explore
epithelial cell	13 studies	41% ± 23%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	25% ± 9%	Explore
capillary endothelial cell	12 studies	26% ± 9%	Explore
gamma-delta T cell	12 studies	24% ± 6%	Explore
dendritic cell	11 studies	41% ± 17%	Explore
GABAergic neuron	11 studies	61% ± 22%	Explore
mature NK T cell	11 studies	23% ± 10%	Explore
myofibroblast cell	11 studies	30% ± 15%	Explore
type I pneumocyte	10 studies	40% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	23% ± 6%	Explore
classical monocyte	10 studies	25% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	22% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	24% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	28% ± 10%	Explore
endothelial cell of artery	10 studies	24% ± 5%	Explore
mucosal invariant T cell	10 studies	26% ± 8%	Explore
connective tissue cell	10 studies	28% ± 12%	Explore
myeloid cell	10 studies	37% ± 14%	Explore
adipocyte	10 studies	61% ± 21%	Explore
monocyte	9 studies	40% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	21% ± 4%	Explore
plasmacytoid dendritic cell	9 studies	20% ± 7%	Explore
vein endothelial cell	9 studies	28% ± 16%	Explore
leukocyte	8 studies	39% ± 19%	Explore
abnormal cell	8 studies	31% ± 19%	Explore
neuron	8 studies	52% ± 21%	Explore
amacrine cell	8 studies	48% ± 10%	Explore
endothelial cell of vascular tree	8 studies	33% ± 19%	Explore
type II pneumocyte	7 studies	49% ± 13%	Explore
non-classical monocyte	7 studies	25% ± 10%	Explore
interneuron	7 studies	64% ± 24%	Explore
retinal ganglion cell	7 studies	49% ± 12%	Explore
club cell	7 studies	44% ± 15%	Explore
retinal cone cell	7 studies	46% ± 11%	Explore
retinal rod cell	7 studies	38% ± 14%	Explore
mesothelial cell	7 studies	42% ± 14%	Explore
respiratory goblet cell	6 studies	41% ± 21%	Explore
secretory cell	6 studies	25% ± 6%	Explore
retina horizontal cell	6 studies	47% ± 5%	Explore
Mueller cell	6 studies	39% ± 9%	Explore
T follicular helper cell	6 studies	22% ± 5%	Explore
goblet cell	6 studies	34% ± 26%	Explore
conventional dendritic cell	5 studies	33% ± 16%	Explore
retinal bipolar neuron	5 studies	45% ± 9%	Explore
glial cell	5 studies	35% ± 10%	Explore
innate lymphoid cell	5 studies	27% ± 12%	Explore
plasma cell	5 studies	43% ± 13%	Explore
brush cell	5 studies	28% ± 6%	Explore
cardiac muscle cell	5 studies	56% ± 14%	Explore
lymphocyte	5 studies	47% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	24% ± 8%	Explore
pancreatic A cell	4 studies	36% ± 21%	Explore
progenitor cell	4 studies	30% ± 10%	Explore
renal alpha-intercalated cell	4 studies	32% ± 18%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	46% ± 17%	Explore
granule cell	4 studies	55% ± 10%	Explore
retinal pigment epithelial cell	4 studies	54% ± 20%	Explore
mononuclear phagocyte	4 studies	34% ± 14%	Explore
OFF-bipolar cell	4 studies	42% ± 7%	Explore
ON-bipolar cell	4 studies	44% ± 10%	Explore
hepatocyte	4 studies	64% ± 21%	Explore
granulocyte	4 studies	24% ± 12%	Explore
muscle cell	4 studies	50% ± 23%	Explore
alveolar macrophage	4 studies	48% ± 21%	Explore
ionocyte	3 studies	30% ± 7%	Explore
exhausted T cell	3 studies	23% ± 7%	Explore
plasmablast	3 studies	35% ± 8%	Explore
glomerular endothelial cell	3 studies	27% ± 5%	Explore
renal beta-intercalated cell	3 studies	35% ± 16%	Explore
GABAergic interneuron	3 studies	60% ± 3%	Explore
precursor B cell	3 studies	21% ± 3%	Explore
squamous epithelial cell	3 studies	42% ± 21%	Explore
serous secreting cell	3 studies	19% ± 6%	Explore
GABAergic amacrine cell	3 studies	51% ± 2%	Explore
glycinergic amacrine cell	3 studies	47% ± 4%	Explore
rod bipolar cell	3 studies	49% ± 3%	Explore
CD4-positive helper T cell	3 studies	23% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	27% ± 6%	Explore
cholangiocyte	3 studies	66% ± 9%	Explore
neural progenitor cell	3 studies	45% ± 11%	Explore
ependymal cell	3 studies	57% ± 16%	Explore
enteroendocrine cell	3 studies	30% ± 7%	Explore
adventitial cell	3 studies	33% ± 7%	Explore
chondrocyte	3 studies	40% ± 15%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 8%	Explore
Schwann cell	3 studies	39% ± 16%	Explore
transit amplifying cell	3 studies	41% ± 34%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	20% ± 2%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
double negative thymocyte	3 studies	29% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	31% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	36% ± 15%	Explore
kidney loop of Henle epithelial cell	3 studies	36% ± 13%	Explore
renal principal cell	3 studies	33% ± 11%	Explore
mural cell	3 studies	60% ± 10%	Explore
mucus secreting cell	3 studies	52% ± 10%	Explore
myoepithelial cell	3 studies	38% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	20 studies	53% ± 23%	Explore
lung	13 studies	33% ± 13%	Explore
peripheral blood	13 studies	23% ± 8%	Explore
eye	10 studies	41% ± 18%	Explore
heart	5 studies	44% ± 14%	Explore
kidney	5 studies	35% ± 15%	Explore
liver	5 studies	38% ± 20%	Explore
intestine	5 studies	22% ± 7%	Explore
breast	4 studies	26% ± 10%	Explore
adipose	4 studies	46% ± 20%	Explore
pancreas	3 studies	40% ± 20%	Explore
lymph node	3 studies	19% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6042.48	1445 / 1445	100%	31.83	183 / 183
brain	100%	5982.13	2637 / 2642	99%	30.86	700 / 705
breast	100%	6735.28	459 / 459	99%	39.83	1106 / 1118
lung	100%	5624.07	577 / 578	99%	22.90	1140 / 1155
ovary	100%	7877.73	180 / 180	98%	17.21	421 / 430
prostate	100%	5746.71	245 / 245	97%	24.89	487 / 502
stomach	100%	4618.79	359 / 359	97%	21.67	277 / 286
thymus	100%	6559.44	653 / 653	96%	22.68	583 / 605
pancreas	99%	3014.15	325 / 328	96%	18.12	171 / 178
intestine	100%	6699.26	966 / 966	95%	16.71	500 / 527
skin	100%	6863.86	1809 / 1809	94%	20.44	444 / 472
uterus	100%	7336.95	170 / 170	93%	17.94	429 / 459
bladder	100%	7011.62	21 / 21	93%	14.85	467 / 504
kidney	100%	3433.07	89 / 89	90%	16.88	808 / 901
adrenal gland	100%	5070.18	258 / 258	90%	14.95	206 / 230
liver	98%	1861.60	222 / 226	70%	9.29	283 / 406
adipose	100%	6241.48	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7700.68	1335 / 1335	0%	0	0 / 0
muscle	100%	7134.19	803 / 803	0%	0	0 / 0
spleen	100%	3935.54	241 / 241	0%	0	0 / 0
heart	95%	3834.49	815 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	18.25	42 / 45
eye	0%	0	0 / 0	81%	9.93	65 / 80
peripheral blood	69%	2165.67	643 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	59%	7.45	17 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_0006954	Biological process	inflammatory response
GO_0009791	Biological process	post-embryonic development
GO_0032259	Biological process	methylation
GO_0000165	Biological process	MAPK cascade
GO_0046697	Biological process	decidualization
GO_0061038	Biological process	uterus morphogenesis
GO_0002674	Biological process	negative regulation of acute inflammatory response
GO_1903699	Biological process	tarsal gland development
GO_0006338	Biological process	chromatin remodeling
GO_1903709	Biological process	uterine gland development
GO_0030317	Biological process	flagellated sperm motility
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0043409	Biological process	negative regulation of MAPK cascade
GO_0001501	Biological process	skeletal system development
GO_0007338	Biological process	single fertilization
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0005794	Cellular component	Golgi apparatus
GO_0005923	Cellular component	bicellular tight junction
GO_0005694	Cellular component	chromosome
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0042800	Molecular function	histone H3K4 methyltransferase activity
GO_0140955	Molecular function	histone H3K36 trimethyltransferase activity
GO_0003682	Molecular function	chromatin binding
GO_0046974	Molecular function	histone H3K9 methyltransferase activity
GO_0140947	Molecular function	histone H3K9me2 methyltransferase activity
GO_0046872	Molecular function	metal ion binding
GO_0140938	Molecular function	histone H3 methyltransferase activity
GO_0046975	Molecular function	histone H3K36 methyltransferase activity
GO_0140948	Molecular function	histone H3K9 monomethyltransferase activity

IV. Literature review

[source]

Gene name	ASH1L
Protein name	Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) ASH1 like histone lysine methyltransferase
Synonyms	KIAA1420 KMT2H
Description	FUNCTION: Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 . Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). .
Accessions	ENST00000676814.1 F8VWK7 ENST00000678699.1 A0A7I2V542 A0A7I2V4H9 H0YI82 ENST00000392403.8 [Q9NR48-2] ENST00000677992.1 ENST00000677042.1 ENST00000679097.1 [Q9NR48-2] A0A7I2V3D6 ENST00000492987.2 A0A7I2YQU9 A0A7I2V4K0 ENST00000679133.1 A0A7I2V316 ENST00000368346.7 [Q9NR48-1] ENST00000678117.1 [Q9NR48-2] ENST00000677825.1 ENST00000677213.1 [Q9NR48-2] ENST00000679333.1 A0A7I2YQL4 ENST00000548830.2 Q9NR48

ASH1L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review