GO_0006954 | OmnibusX

I. Involved cell-cell interactions

	Interactors	Protein name	Directionality	Classification
1	ADM-CALCRL+GPER1+RAMP3	ADML_HUMAN -	Ligand-Receptor	Signaling by Adrenomedullin
2	ANXA1-FPR1	ANXA1_HUMAN - FPR1_HUMAN	Ligand-Receptor	Signaling by Annexin
3	ANXA1-FPR2	ANXA1_HUMAN - FPR2_HUMAN	Ligand-Receptor	Signaling by Annexin
4	ANXA1-FPR3	ANXA1_HUMAN - FPR3_HUMAN	Ligand-Receptor	Signaling by Annexin
5	BMP2-ACVR2A+BMPR1B	BMP2_HUMAN -	Ligand-Receptor	Signaling by BMP
6	BMP2-ACVR2B+BMPR1B	BMP2_HUMAN -	Ligand-Receptor	Signaling by BMP
7	BMP2-BMPR1B+BMPR2	BMP2_HUMAN -	Ligand-Receptor	Signaling by BMP
8	BMP6-ACVR2A+BMPR1B	BMP6_HUMAN -	Ligand-Receptor	Signaling by BMP
9	BMP6-ACVR2B+BMPR1B	BMP6_HUMAN -	Ligand-Receptor	Signaling by BMP
10	BMP6-BMPR1B+BMPR2	BMP6_HUMAN -	Ligand-Receptor	Signaling by BMP
11	C3-C3AR1	CO3_HUMAN - C3AR_HUMAN	Ligand-Receptor	Signaling by Complement
12	C3-C5AR2	CO3_HUMAN - C5AR2_HUMAN	Ligand-Receptor	Signaling by Complement
13	C3-ITGAM+ITGB2	CO3_HUMAN -	Ligand-Receptor	Signaling by Complement
14	C4A-C5AR2	CO4A_HUMAN - C5AR2_HUMAN	Ligand-Receptor	Signaling by Complement
15	C5-C5AR1	CO5_HUMAN - C5AR1_HUMAN	Ligand-Receptor	Signaling by Complement
16	C5-C5AR2	CO5_HUMAN - C5AR2_HUMAN	Ligand-Receptor	Signaling by Complement
17	CCL11-ACKR2	CCL11_HUMAN - ACKR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
18	CCL11-CCR3	CCL11_HUMAN - CCR3_HUMAN	Ligand-Receptor	Signaling by Chemokines
19	CCL13-ACKR2	CCL13_HUMAN - ACKR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
20	CCL13-CCR2	CCL13_HUMAN - CCR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
21	CCL13-CCR3	CCL13_HUMAN - CCR3_HUMAN	Ligand-Receptor	Signaling by Chemokines
22	CCL14-ACKR2	CCL14_HUMAN - ACKR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
23	CCL14-CCR1	CCL14_HUMAN - CCR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
24	CCL14-CCR3	CCL14_HUMAN - CCR3_HUMAN	Ligand-Receptor	Signaling by Chemokines
25	CCL15-CCR1	CCL15_HUMAN - CCR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
26	CCL15-CCR3	CCL15_HUMAN - CCR3_HUMAN	Ligand-Receptor	Signaling by Chemokines
27	CCL16-CCR1	CCL16_HUMAN - CCR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
28	CCL16-CCR2	CCL16_HUMAN - CCR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
29	CCL16-HRH4	CCL16_HUMAN - HRH4_HUMAN	Ligand-Receptor	Signaling by Chemokines
30	CCL17-CCR4	CCL17_HUMAN - CCR4_HUMAN	Ligand-Receptor	Signaling by Chemokines
31	CCL19-CCR7	CCL19_HUMAN - CCR7_HUMAN	Ligand-Receptor	Signaling by Chemokines
32	CCL19-CCRL2	CCL19_HUMAN - CCRL2_HUMAN	Ligand-Receptor	Signaling by Chemokines
33	CCL2-ACKR1	CCL2_HUMAN - ACKR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
34	CCL2-ACKR2	CCL2_HUMAN - ACKR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
35	CCL2-CCR2	CCL2_HUMAN - CCR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
36	CCL21-CCR7	CCL21_HUMAN - CCR7_HUMAN	Ligand-Receptor	Signaling by Chemokines
37	CCL22-CCR4	CCL22_HUMAN - CCR4_HUMAN	Ligand-Receptor	Signaling by Chemokines
38	CCL23-CCR1	CCL23_HUMAN - CCR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
39	CCL23-FPR2	CCL23_HUMAN - FPR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
40	CCL24-CCR3	CCL24_HUMAN - CCR3_HUMAN	Ligand-Receptor	Signaling by Chemokines
41	CCL26-CCR1	CCL26_HUMAN - CCR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
42	CCL26-CCR2	CCL26_HUMAN - CCR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
43	CCL26-CCR3	CCL26_HUMAN - CCR3_HUMAN	Ligand-Receptor	Signaling by Chemokines
44	CCL3-ACKR2	CCL3_HUMAN - ACKR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
45	CCL3-CCR1	CCL3_HUMAN - CCR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
46	CCL3-CCR3	CCL3_HUMAN - CCR3_HUMAN	Ligand-Receptor	Signaling by Chemokines
47	CCL3-CCR5	CCL3_HUMAN - CCR5_HUMAN	Ligand-Receptor	Signaling by Chemokines
48	CCL3L1-CCR1	CCL3L1 - CCR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
49	CCL3L1-CCR3	CCL3L1 - CCR3_HUMAN	Ligand-Receptor	Signaling by Chemokines
50	CCL4-ACKR2	CCL4_HUMAN - ACKR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
51	CCL4-CCR5	CCL4_HUMAN - CCR5_HUMAN	Ligand-Receptor	Signaling by Chemokines
52	CCL5-ACKR1	CCL5_HUMAN - ACKR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
53	CCL5-ACKR2	CCL5_HUMAN - ACKR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
54	CCL5-CCR1	CCL5_HUMAN - CCR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
55	CCL5-CCR3	CCL5_HUMAN - CCR3_HUMAN	Ligand-Receptor	Signaling by Chemokines
56	CCL5-CCR4	CCL5_HUMAN - CCR4_HUMAN	Ligand-Receptor	Signaling by Chemokines
57	CCL5-CCR5	CCL5_HUMAN - CCR5_HUMAN	Ligand-Receptor	Signaling by Chemokines
58	CCL7-ACKR2	CCL7_HUMAN - ACKR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
59	CCL7-CCR1	CCL7_HUMAN - CCR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
60	CCL7-CCR2	CCL7_HUMAN - CCR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
61	CCL7-CCR3	CCL7_HUMAN - CCR3_HUMAN	Ligand-Receptor	Signaling by Chemokines
62	CCL7-CCR5	CCL7_HUMAN - CCR5_HUMAN	Ligand-Receptor	Signaling by Chemokines
63	CCL8-ACKR2	CCL8_HUMAN - ACKR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
64	CCL8-CCR1	CCL8_HUMAN - CCR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
65	CCL8-CCR2	CCL8_HUMAN - CCR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
66	CCL8-CCR3	CCL8_HUMAN - CCR3_HUMAN	Ligand-Receptor	Signaling by Chemokines
67	CCL8-CCR5	CCL8_HUMAN - CCR5_HUMAN	Ligand-Receptor	Signaling by Chemokines
68	CD40LG-CD40	CD40L_HUMAN - TNR5_HUMAN	Ligand-Receptor
69	CD44-SELE	CD44_HUMAN - LYAM2_HUMAN	Ligand-Receptor
70	CSF1-CSF1R	CSF1_HUMAN - CSF1R_HUMAN	Ligand-Receptor	Signaling by Colony-Stimulating factor
71	CXCL1-ACKR1	GROA_HUMAN - ACKR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
72	CXCL1-CXCR2	GROA_HUMAN - CXCR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
73	CXCL10-CXCR3	CXL10_HUMAN - CXCR3_HUMAN	Ligand-Receptor	Signaling by Chemokines
74	CXCL11-CXCR3	CXL11_HUMAN - CXCR3_HUMAN	Ligand-Receptor	Signaling by Chemokines
75	CXCL2-CXCR2	CXCL2_HUMAN - CXCR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
76	CXCL3-CXCR2	CXCL3_HUMAN - CXCR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
77	CXCL5-CXCR2	CXCL5_HUMAN - CXCR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
78	CXCL6-CXCR2	CXCL6_HUMAN - CXCR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
79	CXCL8-ACKR1	IL8_HUMAN - ACKR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
80	CXCL8-CXCR2	IL8_HUMAN - CXCR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
81	CXCL9-CXCR3	CXCL9_HUMAN - CXCR3_HUMAN	Ligand-Receptor	Signaling by Chemokines
82	F11R-ITGAL+ITGB2	JAM1_HUMAN -	Ligand-Receptor	Adhesion by Prothrombin
83	IL12B+IL23A-IL12RB1+IL23R	-	Ligand-Receptor	Signaling by Interleukin
84	IL17A+IL17F-IL17RA+IL17RC	-	Ligand-Receptor	Signaling by Interleukin
85	IL17C-IL17RA+IL17RE	IL17C_HUMAN -	Ligand-Receptor	Signaling by Interleukin
86	IL17F-IL17RA+IL17RC	IL17F_HUMAN -	Ligand-Receptor	Signaling by Interleukin
87	IL18-IL18R1+IL18RAP	IL18_HUMAN -	Ligand-Receptor	Signaling by Interleukin
88	IL1A-IL1R1+IL1RAP	IL1A_HUMAN -	Ligand-Receptor	Signaling by Interleukin
89	IL1A-IL1R2+IL1RAP	IL1A_HUMAN -	Ligand-Receptor	Signaling by Interleukin
90	IL1B-IL1R1+IL1RAP	IL1B_HUMAN -	Ligand-Receptor	Signaling by Interleukin
91	IL1B-IL1R2+IL1RAP	IL1B_HUMAN -	Ligand-Receptor	Signaling by Interleukin
92	IL22-IL10RB+IL22RA1	IL22_HUMAN -	Ligand-Receptor	Signaling by Interleukin
93	IL34-CSF1R	IL34_HUMAN - CSF1R_HUMAN	Ligand-Receptor	Signaling by Interleukin
94	KNG1-BDKRB1	KNG1_HUMAN - BKRB1_HUMAN	Ligand-Receptor	Signaling by Kininogen
95	KNG1-BDKRB2	KNG1_HUMAN - BKRB2_HUMAN	Ligand-Receptor	Signaling by Kininogen
96	LGALS9-HAVCR2	LEG9_HUMAN - HAVR2_HUMAN	Ligand-Receptor	Signaling by Galectin
97	PF4-CXCR3	PLF4_HUMAN - CXCR3_HUMAN	Ligand-Receptor
98	PPBP-CXCR2	CXCL7_HUMAN - CXCR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
99	RARRES2-CCRL2	RARR2_HUMAN - CCRL2_HUMAN	Ligand-Receptor	Signaling by Retinoid acid
100	RARRES2-CMKLR1	RARR2_HUMAN - CML1_HUMAN	Ligand-Receptor	Signaling by Retinoid acid
101	TAC1-TACR1	TKN1_HUMAN - NK1R_HUMAN	Ligand-Receptor	Signaling by Tachykinins
102	TNF-TNFRSF1A	TNFA_HUMAN - TNR1A_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor
103	TNF-TNFRSF1B	TNFA_HUMAN - TNR1B_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor
104	TNFSF4-TNFRSF4	TNFL4_HUMAN - TNR4_HUMAN	Ligand-Receptor	Signaling by Tumor necrosis factor
105	VCAM1-ITGAD+ITGB2	VCAM1_HUMAN -	Ligand-Receptor	Adhesion by VCAM
106	XCL1-XCR1	XCL1_HUMAN - XCR1_HUMAN	Ligand-Receptor	Signaling by Lymphotactin
107	XCL2-XCR1	XCL2_HUMAN - XCR1_HUMAN	Ligand-Receptor	Signaling by Lymphotactin

Name	inflammatory response
ID	GO_0006954
collection_id	Biological process
Description	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
External URL
Genes	CCL19 PLAA ADAM8 KIT CXCR3 TNIP3 stnf-tnr1b_human IL1B SERPINA3 UMOD PLA2G2D PXK MFHAS1 MTOR hpse_human-1 PTAFR URS00000B7E30_9606 SPHK1 THBS1 HAMP NFKBIB AGTR1 CALCA ACER3 DPEP1 FOS C5AR1 CLEC7A CEBPB GGT5 CCL5 CXCL10 TICAM1 IFNA2 ELF3 MACIR URS0000CCE0E6_9606 IL9 TBK1 CCL25 CXCL13 CD47 PRKCZ il6r_human CD180 CERS6 TICAM2 CXCL2 NLRC4 XCR1 NFKB2 IL18RAP GPR33 IL1RL1 NFX1 stnf-tnr1a_human KNG1 IL17A CCR7 HMGB1 FOXP3 THEMIS2 MIF TSPAN18 EPHA2 XCL1 CSF1 ECM1 PTGER2 SELP ORM1 NFKB1 PTGDR GSDMD IL18 PRKD1 mtnf_human-1 IL13 PSTPIP1 CRHBP TNFRSF1B S100A12 RPS6KA4 F11R ITGAL RIPK1 ADORA1 TMIGD3 FPR3 BCL6 COL6A1 IL18R1 PTGFR ACKR2 C5 URS00002C0FCB_9606 TRIM14 IL17F TOLLIP NLRP4 CRH TBXA2R AIF1 C4B S100A8 DHRS7B IRGM PARP4 NOX1 ITCH CXCL9 IKBKB IL17RE CUL3 IKBKG MMP25 CHST1 PARK7 PYDC5 CNR2 CXCR4 APOL3 IL1A POLB ADORA2A CCR3 CCRL2 BMP6 CMKLR1 SMPDL3B FUT7 NLRP3 PPBP MAP3K20 SCYL1 AIM2 PLA2G4B DHX9 TLR1 ZNF580 CCL16 HDAC4 CASP4 OLR1 NDP NFKBID CCR5 SEMA7A CCL23 SCG2 TLR10 PIK3CD CHI3L1 NOS2 MAPKAPK2 AKT1 F2R RPS6KA5 LXN PLA2G4C PRKCQ BLNK TRIL CCL18 S1PR3 IL22 ALOX15 HDAC5 CXCL11 CHST4 URS0000574A2C_9606 IL1RL2 CCL1 MEFV TNFAIP6 PLP1 TLR6 KDM4D FPR2 MEP1B NLRP2 TSPAN2 CCL2 AGR2 PIK3CG AP3B1 TIRAP STAB1 AZU1 AGTR2 NFATC4 NKG7 CD5L PLA2G2A CYBA XCL2 TLR7 ADM PLGRKT TLR2 CDO1 PJA2 LAT NDST1 NRROS LTB4R H2BC1 WNK4 TNFRSF4 PTGIR PLD4 NR1H4 TNFSF4 CX3CL1 CRP IL10RB BDKRB2 KLRG1 CCR2 FFAR4 TLR8 TRIM31 ADGRE5 TACR1 mtnf-tnr1b_human CCR4 SETD4 TUSC2 CD96 STAT3 HNRNPA0 PF4 CCL8 IL34 HK1 PYDC2 SELE RIPK2 BMPR1B BMP2 LYZ IDO1 PTX3 DAB2IP CCL4L1 ASH1L ATRN C4A LY75 TMEM258 TAC4 CCL17 SMAD1 URS00000DF6D0_9606 RARRES2 CXCL8 CHUK FASN HYAL1 GPR68 MGLL FOSL1 URS0000170CF4_9606 GPER1 LY86 TAB2 PTGER4 IL17D MAP2K3 CD40 TXNIP C3 CCL20 NAIP ITGB6 IL23R TMED2 PROK2 PF4V1 CCL13 C5AR2 CD14 REL IRAK2 MAP3K7 FCGR2B TLR4 NLRP9 ODAM PLA2G2E IL5 FUT4 TNF FOLR2 PRDX5 CCL4 NLRP10 PTGER3 AFAP1L2 CHST2 HYAL3 AOC3 IL2RA MSMP F2RL1 CCL15 IGHE CXCR6 CSF1R CXCL1 NCR3 AXL SLC11A1 AIMP1 CARD18 CCL3 GPR32P1 IL17C NR4A1 ZC3H12A IL27 KRT16 TNIP2 GATA3 HCK GBP5 IFI16 CCL21 ACOD1 HRH1 CELA1 CCR1 SCYL3 NFAM1 LY96 CCL22 RELA CCL14 SIGLEC1 mtnf-tnr1a_human PLD3 CCL11 CYP26B1 IL23A BDKRB1 IL1RAP HSPG2 S100A9 LACC1 NOD1 ADORA3 ITGB2 GPR32 CXCL5 HAVCR2 FFAR3 casp7_human-1 HDAC9 CXCR2 CCL26 TNIP1 LOXL3 CCL7 CYBB TRAF3IP2 TNFRSF1A VNN1 IL17B ANXA1 SCUBE1 SCN9A LGALS9 ACKR1 PTGER1 CD2AP WNT5A ABCF1 CAMK4 TLR5 CCL24 CXCL3 TAC1 IRF5 TCIRG1 stnf_human RELB IL17RA STK39 IL17RC CSRP3 NOX4 CD40LG ADGRE2 CD44 VCAM1 AGER LIAS P2RX7 CAMK1D C3AR1 CXCL6 SPINK7 HRH4 NKIRAS2 IL6 NFE2L2 FKRP FPR1 IL1R1 RAC1 NFATC3 TNFAIP3 CCL3L1

inflammatory response

I. Involved cell-cell interactions

II. Literature review