SERPINA3 | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	5 studies	42% ± 19%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SERPINA3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	359572.13	226 / 226	86%	7.63	349 / 406
pancreas	99%	217487.83	324 / 328	66%	4.02	117 / 178
breast	81%	27917.45	373 / 459	70%	4.77	788 / 1118
prostate	77%	43456.36	189 / 245	41%	2.40	205 / 502
lung	88%	12509.18	507 / 578	18%	0.60	205 / 1155
esophagus	61%	6561.48	884 / 1445	34%	1.45	63 / 183
ovary	88%	12403.06	158 / 180	6%	0.29	25 / 430
bladder	86%	14452.29	18 / 21	6%	0.16	28 / 504
stomach	72%	16672.57	260 / 359	14%	0.80	39 / 286
brain	33%	5941.91	865 / 2642	48%	2.46	336 / 705
blood vessel	73%	10964.44	969 / 1335	0%	0	0 / 0
heart	68%	10018.20	583 / 861	0%	0	0 / 0
intestine	58%	4901.84	561 / 966	7%	0.46	39 / 527
kidney	55%	13095.25	49 / 89	6%	0.20	56 / 901
thymus	55%	5252.66	362 / 653	0%	0.00	2 / 605
adrenal gland	46%	3624.94	119 / 258	5%	0.10	12 / 230
adipose	47%	4273.14	569 / 1204	0%	0	0 / 0
uterus	33%	2591.70	56 / 170	11%	0.37	49 / 459
skin	24%	1830.98	427 / 1809	20%	0.87	93 / 472
muscle	39%	6863.01	315 / 803	0%	0	0 / 0
spleen	13%	1891.90	32 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.01	1 / 80
peripheral blood	1%	156.93	7 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0019216	Biological process	regulation of lipid metabolic process
GO_0006953	Biological process	acute-phase response
GO_0006954	Biological process	inflammatory response
GO_0030277	Biological process	maintenance of gastrointestinal epithelium
GO_0010951	Biological process	negative regulation of endopeptidase activity
GO_0035578	Cellular component	azurophil granule lumen
GO_0005615	Cellular component	extracellular space
GO_0072562	Cellular component	blood microparticle
GO_0070062	Cellular component	extracellular exosome
GO_0031093	Cellular component	platelet alpha granule lumen
GO_0005576	Cellular component	extracellular region
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0034774	Cellular component	secretory granule lumen
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0004867	Molecular function	serine-type endopeptidase inhibitor activity
GO_0005515	Molecular function	protein binding

Gene name	SERPINA3
Protein name	Serpin A3 isoform N Serpin A3 isoform T Serpin family A member 3 Serpin family A member 3 (Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 3, isoform CRA_a) Alpha-1-antichymotrypsin (ACT) (Cell growth-inhibiting gene 24/25 protein) (Serpin A3) [Cleaved into: Alpha-1-antichymotrypsin His-Pro-less]
Synonyms	GIG25 GIG24 hCG_2039549 AACT
Description	FUNCTION: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. .
Accessions	ENST00000621603.1 ENST00000556968.2 [P01011-2] ENST00000393080.8 [P01011-1] ENST00000393078.5 [P01011-1] P01011 A0A977TIE0 G3V595 G3V3A0 ENST00000467132.5 [P01011-1] A0A087WY93 ENST00000482740.2 A0A977TIE2 ENST00000555820.1

SERPINA3 report