GPR68 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPR68 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR68 at tissue level.

III. Associated gene sets

GO_0030073Biological processinsulin secretion
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0071467Biological processcellular response to pH
GO_0006954Biological processinflammatory response
GO_0045656Biological processnegative regulation of monocyte differentiation
GO_2001206Biological processpositive regulation of osteoclast development
GO_0030224Biological processmonocyte differentiation
GO_0036035Biological processosteoclast development
GO_0035774Biological processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0005886Cellular componentplasma membrane
GO_0004930Molecular functionG protein-coupled receptor activity

IV. Literature review

[source]
Gene nameGPR68
Protein nameG protein-coupled receptor 68
Ovarian cancer G-protein coupled receptor 1 (OGR-1) (G-protein coupled receptor 68) (GPR12A) (Sphingosylphosphorylcholine receptor)
GPR68 protein
Alternative protein GPR68
SynonymsOGR1
DescriptionFUNCTION: Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer (By similarity). .

AccessionsENST00000529102.1
Q6NWR5
E9PNU7
A1A5B2
L0R5B2
ENST00000531499.2
ENST00000650645.1
ENST00000535815.5
Q6NWR6
Q15743