GO_0007186 | OmnibusX

I. Involved cell-cell interactions

	Interactors	Protein name	Directionality	Classification
1	AGT-AGTR1	ANGT_HUMAN - AGTR1_HUMAN	Ligand-Receptor	Signaling by Angiotensinogen
2	AGT-AGTR2	ANGT_HUMAN - AGTR2_HUMAN	Ligand-Receptor	Signaling by Angiotensinogen
3	AKR1C3-PTGDR	- PD2R_HUMAN	Ligand-Receptor	Signaling by Prostaglandin
4	AKR1C3-PTGDR2	- PD2R2_HUMAN	Ligand-Receptor	Signaling by Prostaglandin
5	AKR1C3-PTGFR	- PF2R_HUMAN	Ligand-Receptor	Signaling by Prostaglandin
6	APOA1-ABCA1	APOA1_HUMAN - ABCA1_HUMAN	Ligand-Receptor	Signaling by Apolipoprotein
7	C3-C3AR1	CO3_HUMAN - C3AR_HUMAN	Ligand-Receptor	Signaling by Complement
8	CCL21-ACKR4	CCL21_HUMAN - ACKR4_HUMAN	Ligand-Receptor	Signaling by Chemokines
9	CCL21-CCR7	CCL21_HUMAN - CCR7_HUMAN	Ligand-Receptor	Signaling by Chemokines
10	CCL23-FPR2	CCL23_HUMAN - FPR2_HUMAN	Ligand-Receptor	Signaling by Chemokines
11	CCL25-ACKR4	CCL25_HUMAN - ACKR4_HUMAN	Ligand-Receptor	Signaling by Chemokines
12	CCL25-CCR9	CCL25_HUMAN - CCR9_HUMAN	Ligand-Receptor	Signaling by Chemokines
13	CCL5-CCR5	CCL5_HUMAN - CCR5_HUMAN	Ligand-Receptor	Signaling by Chemokines
14	CCL5-GPR75	CCL5_HUMAN - GPR75_HUMAN	Ligand-Receptor	Signaling by Chemokines
15	CGA+CGB1-LHCGR	- LSHR_HUMAN	Ligand-Receptor	Signaling by Choriogonadotropin
16	CGA+CGB2-LHCGR	- LSHR_HUMAN	Ligand-Receptor	Signaling by Choriogonadotropin
17	CGA+CGB3-LHCGR	- LSHR_HUMAN	Ligand-Receptor	Signaling by Choriogonadotropin
18	CGA+CGB7-LHCGR	- LSHR_HUMAN	Ligand-Receptor	Signaling by Choriogonadotropin
19	CGA+FSHB-FSHR	- FSHR_HUMAN	Ligand-Receptor	Signaling by Choriogonadotropin
20	CGA+LHB-LHCGR	- LSHR_HUMAN	Ligand-Receptor	Signaling by Choriogonadotropin
21	CGA+TSHB-TSHR	- TSHR_HUMAN	Ligand-Receptor	Signaling by Choriogonadotropin
22	CX3CL1-CX3CR1	X3CL1_HUMAN - CX3C1_HUMAN	Ligand-Receptor	Signaling by Chemokines
23	CXCL1-CXCR1	GROA_HUMAN - CXCR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
24	CXCL12-CXCR4	SDF1_HUMAN - CXCR4_HUMAN	Ligand-Receptor	Signaling by Chemokines
25	CXCL8-CXCR1	IL8_HUMAN - CXCR1_HUMAN	Ligand-Receptor	Signaling by Chemokines
26	EDN1-EDNRA	EDN1_HUMAN - EDNRA_HUMAN	Ligand-Receptor	Signaling by Endothelin
27	F2-F2R	THRB_HUMAN - PAR1_HUMAN	Ligand-Receptor	Adhesion by Prothrombin
28	FSHB-FSHR	FSHB_HUMAN - FSHR_HUMAN	Ligand-Receptor
29	GAST-ADGRG1	GAST_HUMAN - AGRG1_HUMAN	Ligand-Receptor	Signaling by Gastrin
30	GAST-CCKAR	GAST_HUMAN - CCKAR_HUMAN	Ligand-Receptor	Signaling by Gastrin
31	GHRL-GHSR	GHRL_HUMAN - GHSR_HUMAN	Ligand-Receptor	Signaling by Growth hormone-releasing hormone
32	GHRL-GPR39	GHRL_HUMAN - GPR39_HUMAN	Ligand-Receptor	Signaling by Growth hormone-releasing hormone
33	GPHA2+GPHB5-TSHR	- TSHR_HUMAN	Ligand-Receptor
34	C10orf99-GPR15	GP15L_HUMAN - GPR15_HUMAN	Ligand-Receptor
35	INS-INSR	INS_HUMAN - INSR_HUMAN	Ligand-Receptor	Signaling by Insulin-like precursor
36	KISS1-KISS1R	KISS1_HUMAN - KISSR_HUMAN	Ligand-Receptor
37	LHB-LHCGR	LSHB_HUMAN - LSHR_HUMAN	Ligand-Receptor
38	LPAR1-ADGRE5	LPAR1_HUMAN - CD97_HUMAN	Receptor-Receptor	Signaling by Lysophosphatidic acid receptor
39	LPAR2-ADGRE5	LPAR2_HUMAN - CD97_HUMAN	Receptor-Receptor	Signaling by Lysophosphatidic acid receptor
40	NMU-NMUR1	NMU_HUMAN - NMUR1_HUMAN	Ligand-Receptor	Signaling by Neuromedin
41	NPB-NPBWR1	NPB_HUMAN - NPBW1_HUMAN	Ligand-Receptor	Signaling by Neuropeptide precursor
42	NPB-NPBWR2	NPB_HUMAN - NPBW2_HUMAN	Ligand-Receptor	Signaling by Neuropeptide precursor
43	NPW-NPBWR1	NPW_HUMAN - NPBW1_HUMAN	Ligand-Receptor	Signaling by Neuropeptide precursor
44	NPW-NPBWR2	NPW_HUMAN - NPBW2_HUMAN	Ligand-Receptor	Signaling by Neuropeptide precursor
45	PRLH-PRLHR	PRRP_HUMAN - PRLHR_HUMAN	Ligand-Receptor	Signaling by Prolactin
46	PROK2-PROKR1	PROK2_HUMAN - PKR1_HUMAN	Ligand-Receptor	Signaling by Prokineticin
47	PROK2-PROKR2	PROK2_HUMAN - PKR2_HUMAN	Ligand-Receptor	Signaling by Prokineticin
48	PTH-PTH1R	PTHY_HUMAN - PTH1R_HUMAN	Ligand-Receptor	Signaling by Parathyroid hormone
49	PTH-PTH2R	PTHY_HUMAN - PTH2R_HUMAN	Ligand-Receptor	Signaling by Parathyroid hormone
50	SST-SSTR4	SMS_HUMAN - SSR4_HUMAN	Ligand-Receptor	Signaling by Somatostatin
51	SST-SSTR5	SMS_HUMAN - SSR5_HUMAN	Ligand-Receptor	Signaling by Somatostatin
52	TAFA5-FPR2	TAFA5_HUMAN - FPR2_HUMAN	Ligand-Receptor	Signaling by TAFA
53	TAFA5-S1PR2	TAFA5_HUMAN - S1PR2_HUMAN	Ligand-Receptor	Signaling by TAFA
54	TSHB-TSHR	TSHB_HUMAN - TSHR_HUMAN	Ligand-Receptor
55	VIP-SCTR	VIP_HUMAN - SCTR_HUMAN	Ligand-Receptor	Signaling by Vasoactive Intestinal Peptide
56	VIP-VIPR1	VIP_HUMAN - VIPR1_HUMAN	Ligand-Receptor	Signaling by Vasoactive Intestinal Peptide

Name	G protein-coupled receptor signaling pathway
ID	GO_0007186
collection_id	Biological process
Alternative ID	GO:0038042
Exact synonym	G protein coupled receptor protein signaling pathway, G protein coupled receptor protein signalling pathway, G-protein coupled receptor protein signal transduction, G-protein coupled receptor protein signaling pathway, G-protein coupled receptor signalling pathway, G-protein-coupled receptor protein signalling pathway, GPCR signaling pathway, GPCR signalling pathway
Description	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
External URL
Genes	OR51B6 SLC39A9 OR4A5 GPRC5D OR8U1 OR6K6 OR52J3 OR1J2 GPRC6A GPR158 OR52L2P OR6C76 OR2B2 GPBAR1 GNAI2 OR4C46 ARHGEF12 OR14J1 INS AKAP13 GNG13 PTAFR OR8G2P FRS2 OR13G1 OR6C70 GPR55 OR11H1 HTR1A GPR156 GNG3 OR6B2 OR13J1 OR6K2 OR6C3 MRGPRX1 OR8K3 OR7G1 NPR3 AGTR1 SST OR6J1 ENTPD2 OR5B12 ADGRG2 AKR1C2 OR52L1 GNG11 OR1D4 OR2W1 ZNF219 GNG10 ADGRL1 OR52K1 OR4E2 ADGRB3 OR51B4 OR2B6 TAS2R36 GPR83 TAS2R4 CCL5 ADGRF3 CXCL10 OR51C1P OR4F6 RASD1 RAMP3 S1PR2 OR8B12 CCL25 OR2A2 OR2AG1 OR51I2 OR6X1 GNAZ OR10G9 SUCNR1 OR2I1P ITPR3 OR51B2 ADGRG4 OR5M3 ADORA2B GPR142 OR51B5 OR5A2 BAIAP3 XCR1 OR2J2 OR2L13 OR4F17 KISS1 OR51F2 GCG OR52B2 OR11H2 OR8B2 OR5AU1 GPR52 RAPGEF2 CGB7 OR5H15 OR9I1 CCKAR DEFB4A CXCR1 VIP OR52B6 OR7G2 OR56A3 OR2B3 OR7G3 OR8U3 CCR7 TAS2R60 OR52E2 OR56B4 INSR PTH2R OR2V2 OR1G1 OR2AP1 CX3CR1 OR14L1 P2RY11 GPR162 OR5M11 OR6Y1 OR6N2 OR1E3 OR51G1 HCAR2 OR4M2B TULP3 OR9Q2 RGS5 OR10W1 PTGER2 TAS2R31 OR52P1 GPR75 P2RY2 OR2T29 PTGDR OR5H1 OR10A4 OR6C6 OR7C2 GPR65 RAPGEF4 OR6Q1 OR5D18 OR52K2 VN1R3 AREG RPH3AL OR2B8P TAS2R19 RORB RGS9BP LANCL1 RGS3 GPR61 MAS1L OR6B1 LOC112268384 IGF2R TAS2R39 OR8S1 OR51E1 OR10K2 RRH JAK2 OR7D4 OR5AN1 OR4K13 OR2T6 ADORA1 CCR9 GPR12 ADGRG7 OR6C68 RGS7BP TAS2R43 PLCB3 RGS18 OR4F15 GPR25 OR4C6 OR4D6 OR2J1 AKAP12 OR2A25 OR5M8 OR52A1 QRFPR GPR15LG PTGFR C5 TAS2R42 TBXA2R OR11L1 TAS2R1 GPR22 ADRA2B OR8I2 GNB4 ADGRG6 OR4D9 OR6F1 OXTR OR52I1 RAPGEFL1 DEFB1 OR9K2 OR7A10 CXCL9 GNA13 OR13F1 OR5AC1 OR10C1 P2RY12 CCR8 OR5M9 FFAR2 MRGPRX3 OR9G9 OR2L8 OR12D3 OR4N4C GAST PLCB2 OR10A7 OR10J1 CXCR4 OR6B3 TAS1R2 OR5M1 S1PR4 OR9A2 GNG2 TAS2R30 CXCR5 OR6P1 TM2D1 OR2M3 OR10G3 OR9A1P GABBR2 CALM3 ADGRE4P OR5B17 MCHR1 OPN1MW2 TAS2R14 NPFFR2 TAS2R33 CCRL2 CMKLR1 SSTR4 OR5H2 OR11H6 GPR150 OR13C8 GPR180 NPY5R P2RY6 MRGPRD OPN1MW3 OR5H8 OR5T3 TAPT1 RGS14 SCTR TAS2R45 OR1F1 OR5F1 OR10G4 OR5D14 HCAR1 OR10A5 PPARG P2RY13 HTR4 CCR5 PTH RIC8A OR2AJ1 OPN1SW CCL23 OR10H4 OR2S2 GPR176 OR6V1 OR10Z1 TAS2R16 OR1D5 OR52E5 OR56A4 OR2AE1 OR1A1 GNGT1 PTGDR2 APOE GPR63 GNG5B OR2T5 OR4Q2 LPAR5 OR4K17 AKT1 F2R OR4S1 amy2-receptor_human OR10H3 OR10G2 RHO OR51I1 OR8D4 TAS2R20 NPR1 OR5G3 FZD2 OR52A5 RGS4 OR2G3 GPR19 RGS9 OR5L1 OR2D3 FZD6 OR4C45 pik3_human-14 OR1S2 OR51V1 BCAR1 OR10D3 OR56A5 OR5P3 EDNRA GPR37 OR10R2 S1PR3 OR9A4 OPN5 LGR6 TAS2R13 FZD10 OR12D2 GPR27 PROKR1 OR51Q1 CALM2 OR2M2 TAS1R1 OR52D1 OR13H1 OR10H1 OR52E6 GPR139 TAS2R41 MLNR OR8U9 OR5D13 CGB3 OR6C75 FPR2 RGS7 OR7A2P OR8H1 OR7A5 RGS19 OR5B3 CGB2 OR6N1 ADGRB2 OR52N4 OR2H2 TSHR RGS8 CCL2 NPBWR2 gpr88-gi1_human PROKR2 GNB2 OR5H14 OR2B11 OR2G2 PIK3CG OPRD1 HTR5A OR13C2 PRLH OR14I1 TAS2R7 TAS1R3 OPN3 GPR31 OR1L8 GRK5 OR1N1 OR4N2 PTPN6 AGTR2 OR4K14 OR5M10 PIK3CB OR2AK2 UCN CHRM1 GPR143 OR5K2 OR6C74 OR8D2 OR51D1 GNA12 VN1R5 P2RY1 OR2T1 OR5AK3P OR6S1 OR51S1 CARTPT ADGRA2 F2 CHRM3 TPRA1 ADGRL4 OR2W6P OR4N5 OR1S1 P2RY4 RGS10 TAS2R5 OR5K1 FFAR1 GNAI1 OR2T33 GPR17 FKSG35 OR5V1 OR4C3 GNG12 OR8K1 TAS2R50 HTR2B OR1J4 pik3_human-13 GIPC1 PGR RGS21 CELSR2 GNRHR LTB4R GNGT2 AKR1C3 PREX1 PREX2 VN1R1 OR2F2 PLPPR4 OR5D3P OR4M2 OR52E1 OR4D10 MRGPRG A0A0G2JNH3 NPY6R OR8B3 LHB VN1R17P OR2AG2 RIC8B GPR171 RGS11 KCNK2 VN1R2 OR1A2 OR10G8 OR2M4 CX3CL1 OR52W1 GPRC5A CHRM2 OR10V1 OR14A2 OR5AL1 OR1L1 RGS6 MRGPRX4 SORT1 BDKRB2 OR2T35 LHCGR OR52N2 OR11H7 OR10J6P FFAR4 APOC3 ADGRE5 OR8A1 GPR183 AR OR5B2 RGS1 ARHGEF1 OR51L1 RGS17 OR13C9 OR13C6P CGB1 OR11A1 GPR15 NPBWR1 OR5C1 OR13D1 AVPR1A GPR4 OR14C36 GNG8 LGR5 GPR42 OR2G6 OR4D11 MTNR1B OR2T34 RAMP2 OR4F4 OR4A47 OR5T1 AVPR2 PIK3R6 OR4A15 RXFP3 OR51A7 GPR18 ADGRF5 OR2M5 FZD9 OR6C1 NLRP6 MRGPRE NLN OR8D1 GPR173 GNG7 GPR152 OR6A2 FSHB OR4K3 OR5AC2 FZD5 OR1N2 GPR50 APLP2 GPR151 OR2A7 OR2C1 OR3A1 OR1L6 OR9G1 ADGRD1 TAS2R10 OR1R1P NPB TAAR5 CD3E OR6T1 BRS3 PLCB4 CXCL8 OR1I1 OPN1MW OR51A2 OR2A14 TAS2R3 OR4F16 OR9G4 GPR68 GPR182 OR2W3 GRM1 ADGRA3 ADGRF2P ADGRD2 OR3A2 OR1L3 GPER1 GPR160 OR4C13 RGS13 GPR62 OR5BS1P OR2V1 OR2M7 CALM1 OR7D2 C3 OR2A42 OR4N4 OR4C12 OR2T8 OR4S2 OR5B21 PLCB1 OR2A12 OR1E2 GNAT2 PROK2 OR1K1 ADGRF1 OR10A2 OR4D5 GPSM2 OR56B2P OR5P2 LPAR2 OR8B4 OR52E8 GRK2 MRGPRF OR2AT4 OR4F5 NPW FZD1 GNG5 ADGRA1 PDGFRL OR14A16 OR11H4 PDE4A OR2Y1 OR10A3 OR1F2P OR2K2 OR52M1 GPR87 RGS16 OR10H2 GNB1 APLNR ECE2 OR1D2 GHSR OR4F21 TAAR6 OR8H3 SMO FCN1 OR2D2 OR10G7 OR5W2 OR52Z1P NMBR GPR21 VIPR1 OR4M1 P2RY14 OR5AR1 OR4A8 OR10P1 PTGER3 OR14K1 OR8J1 NMUR1 OR1B1 ADGRE3 OR4E1 PIK3R5 OR4X1 KISS1R GNG4 OR10AD1 OR13C5 ADGRE1 OR52B4 OR5K3 OR4D1 GNG14 HTR1E DRD3 OR51T1 GPR161 OPN4 NMU PRLHR INPP5K TAAR9 TAS2R9 OR12D1 CGA F2RL1 OR4B1 TRHR ADRA2A OR5J2 GPR45 TMEM145 TAS2R46 OR3A3 CXCR6 GPR85 OR4L1 OR2H1 OR2T27 TSHB CXCL1 FSHR OR4Q3 OR6C4 OR2A1 OR10T2 OR52N5 PLCE1 GNRHR2 OR10AG1 OR1P1 OR5AK2 VN1R4 TAAR3P OR51F1 OR10AC1 ADGRG1 OR4K5 OR6C2 OR5L2 ADGRB1 CELSR1 NTSR1 GRK3 CMKLR2 GPR179 NPY4R2 OR4K15 OR11G2 CCL21 OR1M1 ABCA1 OR4X2 HRH1 GPR141 OR10J4 OR52E4 AGT OR7A17 GPR153 GPR88 GPRC5B OR4P4 TAAR2 OR2Z1 OR13C3 LPAR1 OR4C11 OR51M1 OR10H5 OR1F12P OR56B1 CELSR3 OR5AS1 OR1Q1 OR10X1 OR10J3 OR9Q1 CCR10 OR5D16 GPR148 OR6K3 OR2L3 OR6M1 OR10Q1 OR4A16 TAAR8 OR2T2 BDKRB1 PTH1R TAS2R40 TAS2R8 OR8G3P CASR OR2T11 OR2W5P RGS12 OR56A1 OR10S1 PDC GPR135 RGR OR8K5 GPR6 ATRNL1 OR4C15 OR8J3 OR1C1 VAV1 TAFA5 OR2A5 GPR32 OR2T10 GHRL OR4D2 OR2C3 FFAR3 OR10A6 OR8G5 OR5H6 ACKR4 S1PR1 ADRA2C FZD4 ADGRG3 amy1-receptor_human ADGRG5 GPR146 GRK6 GPR82 HCAR3 MRGPRX2 OR52A4P GPHB5 OR4A4P OR2F1 BHLHA15 GPR35 OR11H12 OR5A1 PTGER1 OXER1 OR7C1 FZD3 OR7E24 OR4K1 OR52I2 OR51A4 ECE1 ADRA1A OR2L2 ADGRL3 OXGR1 OR5T2 FZD7 OR13C4 GPRC5C OPN1LW ARHGEF11 GPR132 OR5I1 PDGFRB ADRA1D APOA1 FZD8 PDE3B OR1E1 OR4C16 ADGRV1 RAC2 ADGRE2 OR8B8 MTNR1A OR1L4 OR3A4P OR2T3 OR6C65 OR2T7 OR1J1 RGS20 OR8H2 OR4C5 OR51H1 OR8U8 GPR34 OR52H1 OR13C7 GPR39 MAS1 TAS2R38 PDE3A C3AR1 OR2A4 OR4K2 OR51G2 GNB5 OR8J2 EDN1 OR10K1 CXCL12 MC2R DGKQ OR5K4 FPR1 ADRA1B AVPR1B NPY4R ADGRL2 ADGRF4 SSTR5 OR52N1 OR2L5 OR51J1 OR8G1 OR13A1 GNB3 NPFFR1 RAMP1 OR10G6 OR52R1 OR10D4P GRPR TAAR1 OR2T4 OR2T12 RGS2 OR2J3 OR5AP2

G protein-coupled receptor signaling pathway

I. Involved cell-cell interactions

II. Literature review