GPR4 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	5 studies	21% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	3109.61	457 / 459	98%	10.03	1094 / 1118
thymus	100%	2823.03	653 / 653	96%	15.50	578 / 605
lung	100%	3938.04	578 / 578	94%	6.82	1090 / 1155
adrenal gland	95%	886.18	244 / 258	98%	23.45	226 / 230
kidney	100%	1700.08	89 / 89	81%	38.08	733 / 901
stomach	83%	596.11	299 / 359	96%	8.80	275 / 286
uterus	96%	1024.20	164 / 170	81%	5.15	373 / 459
prostate	88%	853.33	215 / 245	80%	4.61	404 / 502
intestine	74%	566.19	716 / 966	93%	7.30	491 / 527
esophagus	70%	569.88	1018 / 1445	96%	9.45	176 / 183
bladder	71%	986.29	15 / 21	93%	6.89	470 / 504
brain	60%	592.54	1592 / 2642	96%	8.56	679 / 705
skin	56%	379.39	1021 / 1809	93%	6.44	438 / 472
ovary	60%	416.42	108 / 180	83%	3.93	355 / 430
pancreas	39%	184.30	128 / 328	99%	11.48	176 / 178
liver	28%	173.26	64 / 226	93%	5.77	379 / 406
adipose	100%	3988.87	1204 / 1204	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.14	1 / 1
heart	99%	1577.44	849 / 861	0%	0	0 / 0
spleen	90%	570.05	217 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	89%	5.07	40 / 45
blood vessel	69%	630.56	927 / 1335	0%	0	0 / 0
muscle	66%	389.93	533 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	66%	2.75	19 / 29
eye	0%	0	0 / 0	50%	2.00	40 / 80
peripheral blood	1%	2.64	6 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0043114	Biological process	regulation of vascular permeability
GO_0060055	Biological process	angiogenesis involved in wound healing
GO_0072144	Biological process	glomerular mesangial cell development
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0035025	Biological process	positive regulation of Rho protein signal transduction
GO_0007200	Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway
GO_0030155	Biological process	regulation of cell adhesion
GO_0010447	Biological process	response to acidic pH
GO_0007189	Biological process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0016525	Biological process	negative regulation of angiogenesis
GO_0005886	Cellular component	plasma membrane
GO_0004930	Molecular function	G protein-coupled receptor activity

Gene name	GPR4
Protein name	G-protein coupled receptor 4 (G-protein coupled receptor 6C.l) (GPR6C.l)
Synonyms
Description	FUNCTION: Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways . Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway . In the brain may mediate central respiratory sensitivity to CO(2)H(+) (By similarity). .
Accessions	P46093 ENST00000323040.5

GPR4 report