Interactors | Protein name | Directionality | Classification | |
|---|---|---|---|---|
| 1 | AGT-AGTR1 | ANGT_HUMAN - AGTR1_HUMAN | Ligand-Receptor | Signaling by Angiotensinogen |
| 2 | EDN1-EDNRA | EDN1_HUMAN - EDNRA_HUMAN | Ligand-Receptor | Signaling by Endothelin |
| 3 | EDN1-EDNRB | EDN1_HUMAN - EDNRB_HUMAN | Ligand-Receptor | Signaling by Endothelin |
| 4 | HCRT-HCRTR2 | OREX_HUMAN - OX2R_HUMAN | Ligand-Receptor | Signaling by Orexin |
| Name | phospholipase C-activating G protein-coupled receptor signaling pathway |
| ID | GO_0007200 |
| collection_id | Biological process |
| Exact synonym | G protein signaling, coupled to IP3 second messenger (phospholipase C activating), G protein signalling, coupled to IP3 second messenger (phospholipase C activating), G-protein coupled receptor signaling pathway coupled to IP3 second messenger, G-protein signaling, coupled to IP3 second messenger (phospholipase C activating), G-protein signalling, coupled to IP3 second messenger (phospholipase C activating), PLC-activating GPCR signaling pathway, phospholipase C-activating G-protein coupled receptor signaling pathway |
| Description | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
| Related synonym | activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger |
| Comment | This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) activity. |
| External URL | |
| Genes | P2RY4FFAR1GPR17P2RY10F2RL1TRHRMC3RP2RY12LTB4RFFAR2GNG13PTAFRNMUR2PLCB2PRKD3GPR32P1GPR55PLCE1AGTR1CMKLR1CALCAGPR157C5AR1LHCGRHRH1P2RY6FFAR4GPR83AGTTACR1F2RL3GPR4ESR1EDNRBHCRTR2GALR2GPR18PTH1RCASRKISS1NTSR2F2RL2GPR33CCKARGPR32OPRK1OPRL1HCRTP2RY8CXCR2PRKD2F2RPLCH2CX3CR1S1PR1P2RY11GPR35EDNRAANO1P2RY2PRKD1ADRA1AORAI1C5AR2GPR139GPR65ADRA1DFPR2LPAR4PIK3CGOPRD1RASGRP4GNB1CCKBRC3AR1PLCB3FPR3EDN1TGM2OPRM1NMBRGPR143ADRA1BFPR1GPR174GPR20PTGER3NMUR1P2RY1GRPRLPAR6HTR2C |