PIK3CG report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PIK3CG at tissue level.

III. Associated gene sets

GO_0002407Biological processdendritic cell chemotaxis
GO_0001525Biological processangiogenesis
GO_0006954Biological processinflammatory response
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0006897Biological processendocytosis
GO_0010897Biological processnegative regulation of triglyceride catabolic process
GO_2000270Biological processnegative regulation of fibroblast apoptotic process
GO_0070527Biological processplatelet aggregation
GO_0042098Biological processT cell proliferation
GO_0045087Biological processinnate immune response
GO_0002679Biological processrespiratory burst involved in defense response
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0030593Biological processneutrophil chemotaxis
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0032252Biological processsecretory granule localization
GO_1903169Biological processregulation of calcium ion transmembrane transport
GO_0035022Biological processpositive regulation of Rac protein signal transduction
GO_0035747Biological processnatural killer cell chemotaxis
GO_0048015Biological processphosphatidylinositol-mediated signaling
GO_0045765Biological processregulation of angiogenesis
GO_0055118Biological processnegative regulation of cardiac muscle contraction
GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0043303Biological processmast cell degranulation
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0036092Biological processphosphatidylinositol-3-phosphate biosynthetic process
GO_0003376Biological processsphingosine-1-phosphate receptor signaling pathway
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0071320Biological processcellular response to cAMP
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0072672Biological processneutrophil extravasation
GO_0033628Biological processregulation of cell adhesion mediated by integrin
GO_0097284Biological processhepatocyte apoptotic process
GO_0002675Biological processpositive regulation of acute inflammatory response
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0016310Biological processphosphorylation
GO_0001819Biological processpositive regulation of cytokine production
GO_0010818Biological processT cell chemotaxis
GO_0042110Biological processT cell activation
GO_0016477Biological processcell migration
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005943Cellular componentphosphatidylinositol 3-kinase complex, class IA
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005944Cellular componentphosphatidylinositol 3-kinase complex, class IB
GO_0106310Molecular functionprotein serine kinase activity
GO_0046875Molecular functionephrin receptor binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0016303Molecular function1-phosphatidylinositol-3-kinase activity
GO_0035005Molecular function1-phosphatidylinositol-4-phosphate 3-kinase activity
GO_0005515Molecular functionprotein binding
GO_0046934Molecular function1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity

IV. Literature review

[source]
Gene namePIK3CG
Protein namePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Alternative protein PIK3CG
Synonyms
DescriptionFUNCTION: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation, activation, and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. .

AccessionsL0R522
P48736
ENST00000440650.6
ENST00000359195.3
ENST00000496166.6
E9PDN7
ENST00000473541.5