CX3CR1 | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	23 studies	30% ± 10%	Explore
non-classical monocyte	15 studies	33% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	40% ± 18%	Explore
microglial cell	12 studies	50% ± 19%	Explore
mature NK T cell	8 studies	24% ± 8%	Explore
CD8-positive, alpha-beta T cell	5 studies	28% ± 9%	Explore
macrophage	4 studies	23% ± 5%	Explore
gamma-delta T cell	4 studies	27% ± 8%	Explore
classical monocyte	3 studies	18% ± 1%	Explore
conventional dendritic cell	3 studies	20% ± 2%	Explore
monocyte	3 studies	26% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	24% ± 7%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CX3CR1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	88%	659.08	2322 / 2642	98%	79.50	691 / 705
breast	57%	117.36	263 / 459	69%	11.76	776 / 1118
kidney	36%	52.09	32 / 89	77%	16.47	690 / 901
prostate	62%	106.21	151 / 245	47%	3.38	235 / 502
thymus	36%	47.78	238 / 653	70%	8.07	425 / 605
lung	74%	245.11	425 / 578	32%	2.59	364 / 1155
spleen	98%	620.62	237 / 241	0%	0	0 / 0
adrenal gland	52%	77.13	133 / 258	31%	2.62	72 / 230
peripheral blood	81%	1694.66	756 / 929	0%	0	0 / 0
ovary	12%	11.28	22 / 180	64%	9.46	277 / 430
pancreas	34%	45.28	111 / 328	33%	2.02	59 / 178
blood vessel	59%	130.74	790 / 1335	0%	0	0 / 0
bladder	43%	71.29	9 / 21	9%	0.49	43 / 504
liver	39%	44.93	88 / 226	7%	0.51	29 / 406
adipose	46%	74.91	553 / 1204	0%	0	0 / 0
uterus	32%	51.14	55 / 170	14%	0.97	62 / 459
muscle	44%	90.23	352 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	41%	3.66	12 / 29
skin	21%	21.12	384 / 1809	16%	1.78	75 / 472
esophagus	26%	31.50	374 / 1445	6%	0.31	11 / 183
tonsil	0%	0	0 / 0	31%	1.67	14 / 45
stomach	13%	14.58	47 / 359	14%	1.27	40 / 286
intestine	19%	22.48	179 / 966	7%	0.43	37 / 527
heart	15%	18.12	133 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	13%	0.79	10 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0002052	Biological process	positive regulation of neuroblast proliferation
GO_0032680	Biological process	regulation of tumor necrosis factor production
GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_0061760	Biological process	antifungal innate immune response
GO_1904141	Biological process	positive regulation of microglial cell migration
GO_0002931	Biological process	response to ischemia
GO_0007200	Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway
GO_0019722	Biological process	calcium-mediated signaling
GO_0050804	Biological process	modulation of chemical synaptic transmission
GO_0035425	Biological process	autocrine signaling
GO_0045428	Biological process	regulation of nitric oxide biosynthetic process
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0045087	Biological process	innate immune response
GO_0090026	Biological process	positive regulation of monocyte chemotaxis
GO_0050769	Biological process	positive regulation of neurogenesis
GO_0006935	Biological process	chemotaxis
GO_0007155	Biological process	cell adhesion
GO_0048874	Biological process	host-mediated regulation of intestinal microbiota composition
GO_0150090	Biological process	multiple spine synapse organization, single dendrite
GO_0030595	Biological process	leukocyte chemotaxis
GO_0006968	Biological process	cellular defense response
GO_0032691	Biological process	negative regulation of interleukin-1 beta production
GO_0007267	Biological process	cell-cell signaling
GO_0006955	Biological process	immune response
GO_0002250	Biological process	adaptive immune response
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0070098	Biological process	chemokine-mediated signaling pathway
GO_0048167	Biological process	regulation of synaptic plasticity
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_1904139	Biological process	regulation of microglial cell migration
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0098883	Biological process	synapse pruning
GO_0060074	Biological process	synapse maturation
GO_0050901	Biological process	leukocyte tethering or rolling
GO_2001234	Biological process	negative regulation of apoptotic signaling pathway
GO_1903721	Biological process	positive regulation of I-kappaB phosphorylation
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0007420	Biological process	brain development
GO_0007613	Biological process	memory
GO_0030336	Biological process	negative regulation of cell migration
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0021626	Biological process	central nervous system maturation
GO_1900272	Biological process	negative regulation of long-term synaptic potentiation
GO_0050767	Biological process	regulation of neurogenesis
GO_0035176	Biological process	social behavior
GO_0110091	Biological process	negative regulation of hippocampal neuron apoptotic process
GO_0009611	Biological process	response to wounding
GO_0060326	Biological process	cell chemotaxis
GO_1904150	Biological process	negative regulation of microglial cell mediated cytotoxicity
GO_0002282	Biological process	microglial cell activation involved in immune response
GO_0097447	Cellular component	dendritic tree
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0160056	Cellular component	macropinosome membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0043005	Cellular component	neuron projection
GO_0032809	Cellular component	neuronal cell body membrane
GO_0009986	Cellular component	cell surface
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0031737	Molecular function	CX3C chemokine receptor binding
GO_0019960	Molecular function	C-X3-C chemokine binding
GO_0016493	Molecular function	C-C chemokine receptor activity
GO_0008528	Molecular function	G protein-coupled peptide receptor activity
GO_0004950	Molecular function	chemokine receptor activity
GO_0016495	Molecular function	C-X3-C chemokine receptor activity
GO_0019957	Molecular function	C-C chemokine binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CX3CR1
Protein name	CX3C chemokine receptor 1 (Fractalkine receptor) CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Beta chemokine receptor-like 1) (CMK-BRL-1) (CMK-BRL1) (Fractalkine receptor) (G-protein coupled receptor 13) (V28)
Synonyms	GPR13 CMKBRL1
Description	FUNCTION: Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis . CX3CR1-CX3CL1 signaling mediates cell migratory functions (By similarity). Responsible for the recruitment of natural killer (NK) cells to inflamed tissues (By similarity). Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival (By similarity). Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung (By similarity). Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells (By similarity). Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis . Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation (By similarity). Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli (By similarity). Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development (By similarity). Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development (By similarity). Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi (By similarity). Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria (By similarity). Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection . Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis . .; FUNCTION: [Isoform 1]: (Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein. .; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein . May have more potent HIV-1 coreceptothr activity than isoform 1 . .; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein . May have more potent HIV-1 coreceptor activity than isoform 1 . .
Accessions	ENST00000542107.5 [P49238-1] ENST00000399220.3 [P49238-1] C9JN40 P49238 ENST00000435290.1 ENST00000412814.1 ENST00000541347.5 [P49238-1] C9JLM2 ENST00000358309.3 [P49238-4]

CX3CR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review