Interactors | Protein name | Directionality | Classification | |
|---|---|---|---|---|
| 1 | JAM2-ITGA4+ITGB1 | JAM2_HUMAN - | Adhesion-Adhesion | Adhesion by JAM |
| 2 | MADCAM1-ITGA4+ITGB7 | MADCA_HUMAN - | Adhesion-Adhesion | |
| 3 | PODXL2-SELE | PDXL2_HUMAN - LYAM2_HUMAN | Ligand-Receptor | Signaling by Podocalyxin-like protein |
| 4 | PODXL2-SELL | PDXL2_HUMAN - LYAM1_HUMAN | Ligand-Receptor | Signaling by Podocalyxin-like protein |
| 5 | PODXL2-SELP | PDXL2_HUMAN - LYAM3_HUMAN | Ligand-Receptor | Signaling by Podocalyxin-like protein |
| 6 | SELPLG-SELE | SELPL_HUMAN - LYAM2_HUMAN | Ligand-Receptor | Signaling by Selectin |
| 7 | SELPLG-SELL | SELPL_HUMAN - LYAM1_HUMAN | Ligand-Receptor | Signaling by Selectin |
| 8 | SELPLG-SELP | SELPL_HUMAN - LYAM3_HUMAN | Ligand-Receptor | Signaling by Selectin |
| 9 | VCAM1-ITGA4+ITGB1 | VCAM1_HUMAN - | Ligand-Receptor | Adhesion by VCAM |
| 10 | VCAM1-ITGA4+ITGB7 | VCAM1_HUMAN - | Ligand-Receptor | Adhesion by VCAM |
| 11 | VCAM1-ITGA9+ITGB1 | VCAM1_HUMAN - | Ligand-Receptor | Adhesion by VCAM |
| Name | leukocyte tethering or rolling |
| ID | GO_0050901 |
| collection_id | Biological process |
| Description | Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection). |
| External URL | |
| Genes |