GCNT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016266Biological processO-glycan processing
GO_0060352Biological processcell adhesion molecule production
GO_0060993Biological processkidney morphogenesis
GO_0032868Biological processresponse to insulin
GO_0016268Biological processO-glycan processing, core 2
GO_1903238Biological processpositive regulation of leukocyte tethering or rolling
GO_0048729Biological processtissue morphogenesis
GO_0009101Biological processglycoprotein biosynthetic process
GO_0050901Biological processleukocyte tethering or rolling
GO_0005802Cellular componenttrans-Golgi network
GO_0005615Cellular componentextracellular space
GO_0000139Cellular componentGolgi membrane
GO_0031985Cellular componentGolgi cisterna
GO_0016020Cellular componentmembrane
GO_0003829Molecular functionbeta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGCNT1
Protein nameBeta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2 beta-1,6-N-acetylglucosaminyltransferase) (C2GlcNAcT) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT) (Core 2 GNT) (Leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase) (C2GnT-L)
Alternative protein GCNT1
SynonymsNACGT2
DescriptionFUNCTION: Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan . The catalysis is metal ion-independent and occurs with inversion of the anomeric configuration of sugar donor (By similarity). Selectively involved in synthesis of mucin-type core 2 O-glycans that serve as scaffolds for the display of selectin ligand sialyl Lewis X epitope by myeloid cells, with an impact on homeostasis and recruitment to inflammatory sites (By similarity). Can also act on glycolipid substrates. Transfers GlcNAc moiety to GalGb4Cer globosides in a reaction step to the synthesis of stage-specific embryonic antigen 1 (SSEA-1) determinant (By similarity). Can use Galbeta1-3GalNAcalpha1- and Galbeta1-3GalNAcbeta1- oligosaccharide derivatives as acceptor substrates (By similarity). .

AccessionsENST00000376730.5
L8E8T5
Q02742
ENST00000444201.6
ENST00000442371.5