SPN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042102Biological processpositive regulation of T cell proliferation
GO_0097190Biological processapoptotic signaling pathway
GO_0042098Biological processT cell proliferation
GO_0007165Biological processsignal transduction
GO_0031295Biological processT cell costimulation
GO_0007163Biological processestablishment or maintenance of cell polarity
GO_0001562Biological processresponse to protozoan
GO_0007162Biological processnegative regulation of cell adhesion
GO_0006935Biological processchemotaxis
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0006968Biological processcellular defense response
GO_0050776Biological processregulation of immune response
GO_0002296Biological processT-helper 1 cell lineage commitment
GO_0006955Biological processimmune response
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0042742Biological processdefense response to bacterium
GO_0050901Biological processleukocyte tethering or rolling
GO_0045060Biological processnegative thymic T cell selection
GO_0050688Biological processregulation of defense response to virus
GO_2000406Biological processpositive regulation of T cell migration
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_2000404Biological processregulation of T cell migration
GO_0007166Biological processcell surface receptor signaling pathway
GO_0001808Biological processnegative regulation of type IV hypersensitivity
GO_0005902Cellular componentmicrovillus
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0009986Cellular componentcell surface
GO_0016605Cellular componentPML body
GO_0005604Cellular componentbasement membrane
GO_0001931Cellular componenturopod
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0031072Molecular functionheat shock protein binding
GO_0030544Molecular functionHsp70 protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPN
Protein nameLeukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)]
Sialophorin
SynonymsCD43
DescriptionFUNCTION: Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells . Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR . Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity). .; FUNCTION: [CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival. .

AccessionsENST00000652691.1
ENST00000563039.2
ENST00000395389.2
P16150
ENST00000436527.5
C9JUK7
ENST00000360121.4