GO_0004888 | OmnibusX

transmembrane signaling receptor activity

I. Involved cell-cell interactions

	Interactors	Protein name	Directionality	Classification
1	CD44-SELE	CD44_HUMAN - LYAM2_HUMAN	Ligand-Receptor
2	ICAM1-SPN	ICAM1_HUMAN - LEUK_HUMAN	Adhesion-Adhesion	Adhesion by ICAM
3	KLRB1-CLEC2D	KLRB1_HUMAN - CLC2D_HUMAN	Ligand-Receptor
4	SEMA4D-CD72	SEM4D_HUMAN - CD72_HUMAN	Ligand-Receptor	Signaling by Semaphorin
5	SEMA4D-PLXNB1	SEM4D_HUMAN - PLXB1_HUMAN	Ligand-Receptor	Signaling by Semaphorin

II. Literature review

Name	transmembrane signaling receptor activity
ID	GO_0004888
collection_id	Molecular function
Alternative ID	GO:0004926, GO:0099600
Exact synonym	transmembrane signalling receptor activity
Description	Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
Comment	This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.
External URL
Genes	ICAM1 tlr2_tlr6_human ENG PLXNB1 NRXN2 CHRNA9 FCRL5 EDA2R GIPR ERBB2 IGSF6 M6PR CD247 GPR158 KIR2DS1 CLEC1A GP1BB KLRC3 MRC1 MARCO intg_a2_b1_human LYVE1 DNER GABRQ intg_a10_b1_human THBD CD300C GLRA1 intg_a4_b1_human FCMR TREML1 SCARB2 LMBR1L MILR1 FCAMR SLC22A17 CD79A gp1b_human SORL1 LGR4 LILRB5 SCARF1 GABBR2 MRGPRX1 tlr1_tlr2_human NRXN3 KIR2DS2 TNFRSF11A FCRL3 IL11RA intg_a6_b1_human LILRB3 CD79B intg_av_b6_human CD72 CR2 intg_a2b_b3_human FCRL2 ADGRE5 TLR3 TLR1 CLDN3 intg_a3_b3_human GLRA2 GLP1R TRGC2 CD69 NFAM1 tlr1_tlr10_human CD4 ANTXR2 RYK LGR5 ERBB3 CD300H IL21R intg_a5_b1_human CD300LF CHRFAM7A CLEC4A LRP8 intg_av_b3_human CD3G EGFR SELE GLRB IL27RA BMPR1B P2RX6 C17orf99 CD300LD NRXN1 LILRA1 TLR10 intg_a9_b1_human KLRF1 intg_a1_b1_human intg_av_b8_human CD300LG tlr4_tlr6_human intg_am_b2_human lrp1_human-1 CD300LB TREM1 FCRL4 intg_av_b5_human CD3E LMBR1 GP6 CD3D CLEC1B GPR182 GLRA3 DCC CD27 gp1b-flna_human tlr2_tlr10_human intg_a4_b7_human TNFRSF10C ACKR1 INTS6 NOTCH1 nlgn1-nlgn1 PIGR TLR5 LGR6 TNFRSF10D KLRC2 PECAM1 LEPR CLEC2D LAG3 FCRLB TLR6 ZACN KLRC4 NPC1 KLRB1 CD300A ANTXR1 TGFBR3 TRPV1 EDAR KIR2DL4 CD44 FCRLA SPN BCAM TLR4 NGFR AGER CLEC12A intg_al_b2_human FCGR2C TNFRSF8 TMIGD3 SIGLEC8 KLRD1 intg_ax_b2_human TREM2 NCR2 CD300E ANTXRL OR52A1 SEMA4D intg_av_b1_human FCRL6 CLDN4 SLAMF1 CHRNA10 IL1R1 TLR2 KLRC1 P2RX5 EVI2A