RYK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_1904948Biological processmidbrain dopaminergic neuron differentiation
GO_0031175Biological processneuron projection development
GO_0007165Biological processsignal transduction
GO_0007275Biological processmulticellular organism development
GO_0007411Biological processaxon guidance
GO_0048846Biological processaxon extension involved in axon guidance
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0007409Biological processaxonogenesis
GO_0071679Biological processcommissural neuron axon guidance
GO_0033674Biological processpositive regulation of kinase activity
GO_0030182Biological processneuron differentiation
GO_0022008Biological processneurogenesis
GO_0022038Biological processcorpus callosum development
GO_0060071Biological processWnt signaling pathway, planar cell polarity pathway
GO_0035567Biological processnon-canonical Wnt signaling pathway
GO_0007416Biological processsynapse assembly
GO_0006468Biological processprotein phosphorylation
GO_1904935Biological processpositive regulation of cell proliferation in midbrain
GO_0036518Biological processchemorepulsion of dopaminergic neuron axon
GO_0048705Biological processskeletal system morphogenesis
GO_0048843Biological processnegative regulation of axon extension involved in axon guidance
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0017147Molecular functionWnt-protein binding
GO_0015026Molecular functioncoreceptor activity
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0005109Molecular functionfrizzled binding
GO_0042813Molecular functionWnt receptor activity
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRYK
Protein nameReceptor like tyrosine kinase
RYK protein
Tyrosine-protein kinase RYK (EC 2.7.10.1)
SynonymsJTK5A
DescriptionFUNCTION: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. .

AccessionsENST00000484106.3
Q8WTZ8
ENST00000486725.1
H7C4P6
A0A0D9SFZ4
ENST00000620660.4 [P34925-2]
ENST00000623711.4 [P34925-1]
P34925