Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 17 studies | 30% ± 12% | |
fibroblast | 10 studies | 25% ± 9% | |
pericyte | 10 studies | 24% ± 8% | |
smooth muscle cell | 10 studies | 22% ± 7% | |
glutamatergic neuron | 10 studies | 39% ± 26% | |
astrocyte | 9 studies | 32% ± 16% | |
oligodendrocyte precursor cell | 8 studies | 31% ± 14% | |
epithelial cell | 8 studies | 35% ± 16% | |
microglial cell | 7 studies | 26% ± 8% | |
GABAergic neuron | 7 studies | 42% ± 21% | |
oligodendrocyte | 7 studies | 28% ± 10% | |
interneuron | 6 studies | 41% ± 25% | |
macrophage | 6 studies | 28% ± 8% | |
basal cell | 6 studies | 33% ± 22% | |
club cell | 6 studies | 22% ± 8% | |
adipocyte | 6 studies | 30% ± 5% | |
endothelial cell of lymphatic vessel | 5 studies | 25% ± 10% | |
neuron | 4 studies | 28% ± 11% | |
ciliated cell | 4 studies | 26% ± 3% | |
type II pneumocyte | 4 studies | 21% ± 7% | |
connective tissue cell | 4 studies | 22% ± 7% | |
goblet cell | 4 studies | 33% ± 23% | |
GABAergic interneuron | 3 studies | 24% ± 2% | |
granule cell | 3 studies | 20% ± 2% | |
retinal pigment epithelial cell | 3 studies | 30% ± 13% | |
mast cell | 3 studies | 16% ± 0% | |
lymphocyte | 3 studies | 21% ± 6% | |
endothelial cell of vascular tree | 3 studies | 28% ± 14% | |
monocyte | 3 studies | 16% ± 0% | |
myofibroblast cell | 3 studies | 27% ± 6% | |
type I pneumocyte | 3 studies | 25% ± 8% | |
transit amplifying cell | 3 studies | 38% ± 29% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3933.66 | 1445 / 1445 | 100% | 27.54 | 183 / 183 |
lung | 100% | 2921.96 | 578 / 578 | 100% | 33.27 | 1155 / 1155 |
ovary | 100% | 7078.31 | 180 / 180 | 100% | 26.96 | 430 / 430 |
breast | 100% | 4357.01 | 459 / 459 | 100% | 31.05 | 1117 / 1118 |
prostate | 100% | 3745.97 | 245 / 245 | 100% | 27.56 | 501 / 502 |
bladder | 100% | 4368.33 | 21 / 21 | 100% | 28.31 | 502 / 504 |
uterus | 100% | 4880.43 | 170 / 170 | 100% | 33.35 | 457 / 459 |
intestine | 100% | 3780.16 | 966 / 966 | 99% | 22.49 | 523 / 527 |
stomach | 100% | 2621.80 | 359 / 359 | 99% | 21.47 | 283 / 286 |
thymus | 100% | 4074.64 | 653 / 653 | 99% | 32.53 | 598 / 605 |
kidney | 100% | 2216.18 | 89 / 89 | 98% | 19.11 | 886 / 901 |
pancreas | 100% | 1828.65 | 327 / 328 | 98% | 22.33 | 174 / 178 |
brain | 97% | 1021.77 | 2566 / 2642 | 99% | 16.91 | 701 / 705 |
skin | 100% | 4085.12 | 1809 / 1809 | 93% | 21.67 | 439 / 472 |
liver | 100% | 1353.27 | 226 / 226 | 83% | 9.55 | 337 / 406 |
adrenal gland | 100% | 2948.86 | 258 / 258 | 76% | 8.25 | 174 / 230 |
adipose | 100% | 4014.85 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3908.59 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 2778.07 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 32.09 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 12.31 | 1 / 1 |
muscle | 100% | 1838.06 | 799 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 2065.33 | 852 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 70% | 7.71 | 56 / 80 |
lymph node | 0% | 0 | 0 / 0 | 66% | 6.24 | 19 / 29 |
peripheral blood | 45% | 653.13 | 414 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007169 | Biological process | cell surface receptor protein tyrosine kinase signaling pathway |
GO_1904948 | Biological process | midbrain dopaminergic neuron differentiation |
GO_0031175 | Biological process | neuron projection development |
GO_0007165 | Biological process | signal transduction |
GO_0007275 | Biological process | multicellular organism development |
GO_0007411 | Biological process | axon guidance |
GO_0048846 | Biological process | axon extension involved in axon guidance |
GO_0043410 | Biological process | positive regulation of MAPK cascade |
GO_0060070 | Biological process | canonical Wnt signaling pathway |
GO_0007409 | Biological process | axonogenesis |
GO_0071679 | Biological process | commissural neuron axon guidance |
GO_0033674 | Biological process | positive regulation of kinase activity |
GO_0030182 | Biological process | neuron differentiation |
GO_0022008 | Biological process | neurogenesis |
GO_0022038 | Biological process | corpus callosum development |
GO_0060071 | Biological process | Wnt signaling pathway, planar cell polarity pathway |
GO_0035567 | Biological process | non-canonical Wnt signaling pathway |
GO_0007416 | Biological process | synapse assembly |
GO_0006468 | Biological process | protein phosphorylation |
GO_1904935 | Biological process | positive regulation of cell proliferation in midbrain |
GO_0036518 | Biological process | chemorepulsion of dopaminergic neuron axon |
GO_0048705 | Biological process | skeletal system morphogenesis |
GO_0048843 | Biological process | negative regulation of axon extension involved in axon guidance |
GO_0043235 | Cellular component | receptor complex |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0017147 | Molecular function | Wnt-protein binding |
GO_0015026 | Molecular function | coreceptor activity |
GO_0004888 | Molecular function | transmembrane signaling receptor activity |
GO_0004713 | Molecular function | protein tyrosine kinase activity |
GO_0005109 | Molecular function | frizzled binding |
GO_0042813 | Molecular function | Wnt receptor activity |
GO_0004714 | Molecular function | transmembrane receptor protein tyrosine kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | RYK |
Protein name | Receptor like tyrosine kinase RYK protein Tyrosine-protein kinase RYK (EC 2.7.10.1) |
Synonyms | JTK5A |
Description | FUNCTION: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. . |
Accessions | ENST00000484106.3 Q8WTZ8 ENST00000486725.1 H7C4P6 A0A0D9SFZ4 ENST00000620660.4 [P34925-2] ENST00000623711.4 [P34925-1] P34925 |