FCRL3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FCRL3 at tissue level.

III. Associated gene sets

GO_0045577Biological processregulation of B cell differentiation
GO_0090279Biological processregulation of calcium ion import
GO_0050859Biological processnegative regulation of B cell receptor signaling pathway
GO_0034163Biological processregulation of toll-like receptor 9 signaling pathway
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0050864Biological processregulation of B cell activation
GO_0006955Biological processimmune response
GO_0002638Biological processnegative regulation of immunoglobulin production
GO_1905184Biological processpositive regulation of protein serine/threonine phosphatase activity
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0007338Biological processsingle fertilization
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009897Cellular componentexternal side of plasma membrane
GO_0031528Cellular componentmicrovillus membrane
GO_0009986Cellular componentcell surface
GO_0019903Molecular functionprotein phosphatase binding
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0019900Molecular functionkinase binding
GO_1990782Molecular functionprotein tyrosine kinase binding
GO_0019902Molecular functionphosphatase binding

IV. Literature review

[source]
Gene nameFCRL3
Protein nameFc receptor like 3
Fc receptor-like protein 3 (FcR-like protein 3) (FcRL3) (Fc receptor homolog 3) (FcRH3) (IFGP family protein 3) (hIFGP3) (Immune receptor translocation-associated protein 3) (MAIA) (SH2 domain-containing phosphatase anchor protein 2) (CD antigen CD307c)
SynonymsFCRH3
IFGP3
SPAP2
IRTA3
DescriptionFUNCTION: Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells . Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling . Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells . Acts as a human-specific epitope on the cell surface of oocytes (oolemma) and plays a role during sperm-egg adhesion and fusion . Interacts with the IZUMO1-IZUMO1R/JUNO sperm-egg complex and replaces IZUMO1R/JUNO as IZUMO1 receptor during fertilization, thereby permitting species-specific gamete fusion . .

AccessionsENST00000492769.5 [Q96P31-3]
R4GNJ6
Q96P31
ENST00000485028.5 [Q96P31-1]
ENST00000368184.8 [Q96P31-1]
ENST00000477837.5 [Q96P31-2]
ENST00000496769.1
ENST00000368186.9 [Q96P31-6]