external side of plasma membrane

I. Involved cell-cell interactions

[source]
Interactors
Protein name
Directionality
Classification
1B2M+CD1B-IL6ST - IL6RB_HUMANLigand-Receptor
2CD24-SELPCD24_HUMAN - LYAM3_HUMANLigand-Receptor
3CD248-IL6RCD248_HUMAN - IL6RA_HUMANLigand-Receptor
4CD274-CD80PD1L1_HUMAN - CD80_HUMANLigand-Receptor
5CD274-PDCD1PD1L1_HUMAN - PDCD1_HUMANLigand-Receptor
6CD34-SELLCD34_HUMAN - LYAM1_HUMANLigand-Receptor
7CD34-SELPCD34_HUMAN - LYAM3_HUMANLigand-Receptor
8CD40LG-CD40CD40L_HUMAN - TNR5_HUMANLigand-Receptor
9CD40LG-ITGA2B+ITGB3CD40L_HUMAN - Ligand-Receptor
10CD40LG-ITGA5+ITGB1CD40L_HUMAN - Ligand-Receptor
11CD80-CD28CD80_HUMAN - CD28_HUMANLigand-Receptor
12CD80-CTLA4CD80_HUMAN - CTLA4_HUMANLigand-Receptor
13CD86-CD28CD86_HUMAN - CD28_HUMANLigand-Receptor
14CD86-CTLA4CD86_HUMAN - CTLA4_HUMANLigand-Receptor
15CRLF2-CRLF2+IL7RCRLF2_HUMAN - Receptor-Receptor
16CXCL10-CXCR3CXL10_HUMAN - CXCR3_HUMANLigand-ReceptorSignaling by Chemokines
17CXCL12-CXCR4SDF1_HUMAN - CXCR4_HUMANLigand-ReceptorSignaling by Chemokines
18CXCL9-CXCR3CXCL9_HUMAN - CXCR3_HUMANLigand-ReceptorSignaling by Chemokines
19EBI3+IL12A-IL12RB2+IL6ST - Ligand-ReceptorSignaling by Interleukin
20EBI3+IL27-IL27RA+IL6ST - Ligand-ReceptorSignaling by Interleukin
21EFNA5-EPHA5EFNA5_HUMAN - EPHA5_HUMANLigand-ReceptorSignaling by Ephrin
22F10-ITGAM+ITGB2FA10_HUMAN - Ligand-ReceptorAdhesion by Prothrombin
23F2-GP1BA+GP1BBTHRB_HUMAN - Ligand-ReceptorAdhesion by Prothrombin
24F2-ITGA2B+ITGB3THRB_HUMAN - Ligand-ReceptorAdhesion by Prothrombin
25F2-ITGAV+ITGB3THRB_HUMAN - Ligand-ReceptorAdhesion by Prothrombin
26F2-THBDTHRB_HUMAN - TRBM_HUMANLigand-ReceptorAdhesion by Prothrombin
27FASLG-FASTNFL6_HUMAN - TNR6_HUMANLigand-ReceptorSignaling by Tumor necrosis factor
28FCER2-ITGAM+ITGB2FCER2_HUMAN - Receptor-ReceptorSignaling by FC receptor
29FCER2-ITGAV+ITGB3FCER2_HUMAN - Receptor-ReceptorSignaling by FC receptor
30FCER2-ITGAX+ITGB2FCER2_HUMAN - Receptor-ReceptorSignaling by FC receptor
31FGA+FGB+FGG-ITGA2B+ITGB3 - Ligand-ReceptorAdhesion by Fibribogen
32FGA+FGB+FGG-ITGAM+ITGB2 - Ligand-ReceptorAdhesion by Fibribogen
33FGA+FGB+FGG-ITGAX+ITGB2 - Ligand-ReceptorAdhesion by Fibribogen
34GP1BA-ITGAM+ITGB2GP1BA_HUMAN - Ligand-Receptor
35HFE-TFRCHFE_HUMAN - TFR1_HUMANLigand-Receptor
36ICAM1-ITGALICAM1_HUMAN - ITAL_HUMANLigand-ReceptorAdhesion by ICAM
37ICAM1-ITGAL+ITGB2ICAM1_HUMAN - Ligand-ReceptorAdhesion by ICAM
38ICAM1-ITGAM+ITGB2ICAM1_HUMAN - Ligand-ReceptorAdhesion by ICAM
39ICAM1-ITGAX+ITGB2ICAM1_HUMAN - Ligand-ReceptorAdhesion by ICAM
40ICAM1-SPNICAM1_HUMAN - LEUK_HUMANAdhesion-AdhesionAdhesion by ICAM
41IL12A+IL12B-IL12RB1+IL12RB2 - Ligand-ReceptorSignaling by Interleukin
42IL12B+IL23A-IL12RB1+IL23R - Ligand-ReceptorSignaling by Interleukin
43IL13-IL13RA1+IL4RIL13_HUMAN - Ligand-ReceptorSignaling by Interleukin
44IL13-IL13RA2IL13_HUMAN - I13R2_HUMANLigand-ReceptorSignaling by Interleukin
45MICA-HCST+KLRK1MICA_HUMAN - Ligand-Receptor
46MICB-HCST+KLRK1MICB_HUMAN - Ligand-Receptor
47PDCD1LG2-PDCD1PD1L2_HUMAN - PDCD1_HUMANLigand-Receptor
48PLAU-PLAURUROK_HUMAN - UPAR_HUMANLigand-ReceptorSignaling by Plasminogen Activator
49PLAUR-ITGA4+ITGB1UPAR_HUMAN - Receptor-ReceptorSignaling by Plasminogen Activator
50PLAUR-ITGAV+ITGB3UPAR_HUMAN - Receptor-ReceptorSignaling by Plasminogen Activator
51PLG-ITGA2B+ITGB3PLMN_HUMAN - Ligand-Receptor
52PTPRC-CD22PTPRC_HUMAN - CD22_HUMANReceptor-Receptor
53RAET1E-HCST+KLRK1N2DL4_HUMAN - Ligand-ReceptorSignaling by Killer Cell Lectin Like Receptor K1
54RAET1G-HCST+KLRK1RET1G_HUMAN - Ligand-ReceptorSignaling by Killer Cell Lectin Like Receptor K1
55RAET1L-HCST+KLRK1RET1L_HUMAN - Ligand-ReceptorSignaling by Killer Cell Lectin Like Receptor K1
56SEMA7A-ITGA1+ITGB1SEM7A_HUMAN - Ligand-ReceptorSignaling by Semaphorin
57THBS1-CD36TSP1_HUMAN - CD36_HUMANLigand-ReceptorSignaling by Thrombospondin precursor
58THBS1-ITGA2B+ITGB3TSP1_HUMAN - Ligand-ReceptorAdhesion by Thrombospondin
59THBS1-ITGA3+ITGB1TSP1_HUMAN - Ligand-ReceptorAdhesion by Thrombospondin
60THBS1-ITGAV+ITGB3TSP1_HUMAN - Ligand-ReceptorAdhesion by Thrombospondin
61THY1-ITGAM+ITGB2THY1_HUMAN - Adhesion-AdhesionAdhesion by antigen THY1
62THY1-ITGAV+ITGB3THY1_HUMAN - Adhesion-AdhesionAdhesion by antigen THY1
63THY1-ITGAX+ITGB2THY1_HUMAN - Adhesion-AdhesionAdhesion by antigen THY1
64ULBP1-HCST+KLRK1N2DL1_HUMAN - Ligand-ReceptorSignaling by Killer Cell Lectin Like Receptor K1
65ULBP2-HCST+KLRK1N2DL2_HUMAN - Ligand-ReceptorSignaling by Killer Cell Lectin Like Receptor K1
66ULBP3-HCST+KLRK1N2DL3_HUMAN - Ligand-ReceptorSignaling by Killer Cell Lectin Like Receptor K1
67VCAM1-ITGA4+ITGB1VCAM1_HUMAN - Ligand-ReceptorAdhesion by VCAM
68VCAM1-ITGA4+ITGB7VCAM1_HUMAN - Ligand-ReceptorAdhesion by VCAM
69VCAM1-ITGA9+ITGB1VCAM1_HUMAN - Ligand-ReceptorAdhesion by VCAM
70VCAM1-ITGAD+ITGB2VCAM1_HUMAN - Ligand-ReceptorAdhesion by VCAM

II. Literature review

[source]
Nameexternal side of plasma membrane
IDGO_0009897
collection_id

Cellular component

Exact synonym

external leaflet of plasma membrane, outer surface of cytoplasmic membrane

Description

The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.

External URL
Genes
ITGA2KITBTNL9CXCR3FOLR3ITGA8TRGV3SCNN1ALIFRGRIA2GLRA1MS4A1THBS1LY9PDGFRAIGSF21ITGA6CD1DNT5EIL11RABTN1A1CALRVTCN1FCGR3ACXCL10ITGAMITGADCD36CD19CD163TRGV4CD80MFGE8CD274BMPR1AIL27RACD244XCR1IL1RL1IZUMO1RGP1BANRCAMCXCR1IL7RCLEC14APTPRCIL5RAIL17ACCR7CRLF1BTN2A3PINSRERMAPCD3DCLEC4CCX3CR1CLEC4DA0A0G2JPB7ADAM21IL6RLOC102723996AMOTCD24COLEC10MOGFASCLEC4GSELPCDH13LEPRSELLIL13CAPN2CRLF2FCN2ITGALTRPV1TNFRSF14TFR2IL12RB2BTN3A2FLOT1FCRLACSF2RBCCR9CLEC6AKLRD1IDESLAMF6IL12RB1ITGA4BTNL3ACKR2RTBDNPLET1KLRC1CD200R1abeta-42_humanENGHLA-GGPC4RAET1LRAET1ECLEC2BCXCL9IL6STKLRC3DAG1CCR8AZGP1HLA-DRB1UMODL1PDCD1IL13RA1ACECXCR4CD207CD22CD79AFCER1GCXCR5ITGAVBTN3A1DNAI2CD83CCR3EBI3FCRL3CLPTM1CCRL2MCAMP2RX1ITGA11SLC22A11ADAM20RS1ITGA10PLAUCD1BCD5HLA-CANXA5KCNJ3CD209HLA-AADAM9SLAMF9GSRCLEC4EIL21RIL31RACCR5SEMA7ATAS2R16ITGA5ACKR3ITGB3ALCAMICOSLGFCGR1BPintg_am_b2_humanPKHD1CTSBTFRCKLRK1CD302FCER2CSF2RACD59LRRC32CLEC4MPRLRSCNN1GOSMRCD1ETRGV1KLRC4GFRA2CD34ULBP1BCAMTNFRSF18BTN3A3CD84PLGB2MFOLR1FCGR2AIL12BFCN3CTLA4TRPM8RAET1GSLAMF1TRGV8CD2ENPEPF2PDCD1LG2THY1CHRNA4CD248SLC4A3ADAM29FGAATP6AP2TNFRSF4upa-upar_humanCHRNB2SCNN1BCD28PRNPLAMP1IL2RGIL2RBBTNL2TRGV9TRGC1LILRB1MR1TNFRSF11AST14PLAURCOLEC11MS4A2CCR6CD79BCTSKCCR2TLR8FCRL2IL13RA2FCGRTTNFRSF9MBL2CCR4GPIHBP1ITGAEGP2GFRA3MPLCD3Gabeta-42-oligomer_humanSELERTN4RTMEM123BTN2A2CD163L1CD33CD1CHLA-FHLA-ELY75FCRL4CD3EKDRIL4RCSF3RCD27ADGRA3FCGR3BNCAM1CD40KLRC2ITGB6BTNL10PIL23RFGF8F3CLEC2DASGR1FCRLBCD74MUC17FCGR1AEFNA5CD14ADAM30TCN2FCGR2BTLR4MICASPNEPORFCGR2CENPP3TRGV5NEU3SPA17CNTFRGFRA4HLA-BTNFAQP4FCN1FOLR2STAB2HYAL2ASTN1SLC2A4ADGRE1ENOX1CLEC12BCD1ACHADLICAM1HLA-HLDLRADAFCRL5IL2RAFGGCXCR6TRGV2CD86THBDITGA2BENOX2LY6G5CMILR1SDC1CD200R1LBTNL8P4HBCDH5ABCA1CD276F10TRGC2CCR1LY6G6DCD69CD226BTN2A1CD4EPHA5ITGA9CCR10SERPINA5CLEC4ACLEC4FHFETMC1C17orf99ITGA3ABCG1ITGB2GHRGFRA1CXCR2ITGB1LRP2MICBB4GALT1ACKR4MAP3K5S1PR1ANPEPCEACAM21HHLA2SCUBE1ITGAXLY6G5BPECAM1CD9CLEC10ALAG3ECE1ITGA7FASLGRTN4RL2CD40LGANTXR1TGFBR3CD8AMFAP3MUC16TGFBR2CLCN3VCAM1LRRC24SLAMF7P2RX7CA4HEG1TNFRSF13CLY6G6CULBP2FCER1APRNDCXCL12ATP1B2FCRL6CLEC17AULBP3ITGA1FGBGFRALIL3RAASGR2IL1R1IL9R