LAMP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140507Biological processgranzyme-mediated programmed cell death signaling pathway
GO_0045954Biological processpositive regulation of natural killer cell mediated cytotoxicity
GO_0043323Biological processpositive regulation of natural killer cell degranulation
GO_0007042Biological processlysosomal lumen acidification
GO_0046718Biological processsymbiont entry into host cell
GO_0050821Biological processprotein stabilization
GO_0090160Biological processGolgi to lysosome transport
GO_1902513Biological processregulation of organelle transport along microtubule
GO_0072594Biological processestablishment of protein localization to organelle
GO_0009897Cellular componentexternal side of plasma membrane
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0044754Cellular componentautolysosome
GO_0005764Cellular componentlysosome
GO_0000421Cellular componentautophagosome membrane
GO_0035577Cellular componentazurophil granule membrane
GO_0042383Cellular componentsarcolemma
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0061474Cellular componentphagolysosome membrane
GO_0005770Cellular componentlate endosome
GO_0005771Cellular componentmultivesicular body
GO_0005737Cellular componentcytoplasm
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0010008Cellular componentendosome membrane
GO_0101004Cellular componentcytolytic granule membrane
GO_0042470Cellular componentmelanosome
GO_0005765Cellular componentlysosomal membrane
GO_0019899Molecular functionenzyme binding
GO_0019904Molecular functionprotein domain specific binding
GO_0008200Molecular functionion channel inhibitor activity
GO_0001618Molecular functionvirus receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLAMP1
Protein nameLysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a)
Synonyms
DescriptionFUNCTION: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis . Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity . Also plays an important role in NK-cells cytotoxicity . Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule . In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content . Presents carbohydrate ligands to selectins . .; FUNCTION: (Microbial infection) Acts as a receptor for Lassa virus glycoprotein . Promotes also fusion of the virus with host membrane in less acidic endosomes . .; FUNCTION: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. .

AccessionsP11279
ENST00000332556.5 [P11279-1]