CXCL12 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	37 studies	46% ± 21%	Explore
connective tissue cell	16 studies	45% ± 22%	Explore
endothelial cell	14 studies	27% ± 11%	Explore
endothelial cell of artery	12 studies	53% ± 17%	Explore
pericyte	12 studies	32% ± 11%	Explore
smooth muscle cell	12 studies	34% ± 13%	Explore
macrophage	12 studies	30% ± 15%	Explore
capillary endothelial cell	6 studies	22% ± 11%	Explore
myofibroblast cell	5 studies	48% ± 16%	Explore
kidney loop of Henle epithelial cell	4 studies	23% ± 5%	Explore
endothelial cell of vascular tree	3 studies	25% ± 3%	Explore
microglial cell	3 studies	31% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
intestine	5 studies	34% ± 12%	Explore
lung	3 studies	29% ± 14%	Explore
adipose	3 studies	21% ± 6%	Explore
breast	3 studies	20% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	21833.33	459 / 459	96%	73.56	1078 / 1118
thymus	98%	11071.08	640 / 653	87%	43.49	526 / 605
pancreas	98%	8089.72	321 / 328	85%	39.24	152 / 178
skin	89%	12371.94	1605 / 1809	83%	37.69	391 / 472
kidney	81%	6163.89	72 / 89	80%	41.17	719 / 901
liver	92%	8311.61	207 / 226	61%	22.71	248 / 406
lung	78%	4548.57	452 / 578	73%	19.42	845 / 1155
ovary	79%	5860.46	143 / 180	71%	31.20	306 / 430
uterus	100%	19943.44	170 / 170	44%	26.22	202 / 459
intestine	89%	10231.94	855 / 966	53%	12.19	278 / 527
prostate	64%	3924.16	156 / 245	74%	15.70	370 / 502
bladder	90%	6920.48	19 / 21	46%	16.74	231 / 504
adrenal gland	76%	4244.81	196 / 258	49%	21.48	113 / 230
esophagus	79%	7296.39	1139 / 1445	43%	10.84	78 / 183
stomach	43%	3283.59	156 / 359	60%	17.64	171 / 286
spleen	100%	22096.54	241 / 241	0%	0	0 / 0
adipose	100%	26993.97	1203 / 1204	0%	0	0 / 0
heart	98%	8354.47	846 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	38.91	28 / 29
blood vessel	94%	12090.77	1257 / 1335	0%	0	0 / 0
brain	3%	98.08	81 / 2642	70%	13.57	494 / 705
tonsil	0%	0	0 / 0	71%	21.47	32 / 45
muscle	59%	2628.14	471 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	16%	2.28	13 / 80
peripheral blood	1%	19.29	6 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0033603	Biological process	positive regulation of dopamine secretion
GO_0038146	Biological process	chemokine (C-X-C motif) ligand 12 signaling pathway
GO_0043434	Biological process	response to peptide hormone
GO_0008064	Biological process	regulation of actin polymerization or depolymerization
GO_0007165	Biological process	signal transduction
GO_0008344	Biological process	adult locomotory behavior
GO_0009615	Biological process	response to virus
GO_0090026	Biological process	positive regulation of monocyte chemotaxis
GO_1990478	Biological process	response to ultrasound
GO_0050966	Biological process	detection of mechanical stimulus involved in sensory perception of pain
GO_0001764	Biological process	neuron migration
GO_0006935	Biological process	chemotaxis
GO_0007155	Biological process	cell adhesion
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0045785	Biological process	positive regulation of cell adhesion
GO_0031100	Biological process	animal organ regeneration
GO_1904018	Biological process	positive regulation of vasculature development
GO_0090280	Biological process	positive regulation of calcium ion import
GO_0038160	Biological process	CXCL12-activated CXCR4 signaling pathway
GO_0006955	Biological process	immune response
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0070098	Biological process	chemokine-mediated signaling pathway
GO_0001938	Biological process	positive regulation of endothelial cell proliferation
GO_0030335	Biological process	positive regulation of cell migration
GO_0050965	Biological process	detection of temperature stimulus involved in sensory perception of pain
GO_0001666	Biological process	response to hypoxia
GO_1902230	Biological process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO_0008015	Biological process	blood circulation
GO_1990869	Biological process	cellular response to chemokine
GO_1903237	Biological process	negative regulation of leukocyte tethering or rolling
GO_0045666	Biological process	positive regulation of neuron differentiation
GO_0033622	Biological process	integrin activation
GO_2000406	Biological process	positive regulation of T cell migration
GO_0050930	Biological process	induction of positive chemotaxis
GO_2000669	Biological process	negative regulation of dendritic cell apoptotic process
GO_0022029	Biological process	telencephalon cell migration
GO_0048842	Biological process	positive regulation of axon extension involved in axon guidance
GO_0060326	Biological process	cell chemotaxis
GO_0007411	Biological process	axon guidance
GO_0006952	Biological process	defense response
GO_0009897	Cellular component	external side of plasma membrane
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0008009	Molecular function	chemokine activity
GO_0005102	Molecular function	signaling receptor binding
GO_0008083	Molecular function	growth factor activity
GO_0005178	Molecular function	integrin binding
GO_0042379	Molecular function	chemokine receptor binding
GO_0045236	Molecular function	CXCR chemokine receptor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CXCL12
Protein name	Stromal cell-derived factor 1 (SDF-1) (hSDF-1) (C-X-C motif chemokine 12) (Intercrine reduced in hepatomas) (IRH) (hIRH) (Pre-B cell growth-stimulating factor) (PBSF) [Cleaved into: SDF-1-beta(3-72); SDF-1-alpha(3-67)]
Synonyms	SDF1A SDF1 SDF1B
Description	FUNCTION: Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner . Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity). .
Accessions	ENST00000343575.11 [P48061-2] P48061 ENST00000374429.6 [P48061-1] ENST00000395793.7 [P48061-7] ENST00000395794.2 [P48061-4] ENST00000374426.6 [P48061-3]

CXCL12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review