GO_0001666 | OmnibusX

response to hypoxia

I. Involved cell-cell interactions

	Interactors	Protein name	Directionality	Classification
1	ANGPT2-TEK	ANGP2_HUMAN - TIE2_HUMAN	Ligand-Receptor	Signaling by Angiopoietin
2	CXCL12-CXCR4	SDF1_HUMAN - CXCR4_HUMAN	Ligand-Receptor	Signaling by Chemokines
3	CXCL12-DPP4	SDF1_HUMAN - DPP4_HUMAN	Ligand-Receptor	Signaling by Chemokines
4	TGFB2-TGFBR3	TGFB2_HUMAN - TGBR3_HUMAN	Ligand-Receptor	Signaling by Transforming growth factor
5	TGFB3-TGFBR3	TGFB3_HUMAN - TGBR3_HUMAN	Ligand-Receptor	Signaling by Transforming growth factor

II. Literature review

Name	response to hypoxia
ID	GO_0001666
collection_id	Biological process
Exact synonym	response to hypoxic stress, response to lowered oxygen tension
Description	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
Comment	Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
External URL
Genes	ALKBH5 ITGA2 ERCC3 POSTN ADA CHRNA4 SLC2A8 MT3 ATM PRKAA1 LONP1 CASP3 PLEKHN1 UCP3 EGLN3 PML SMAD4 CA9 RYR1 FUNDC1 ABAT CHRNB2 AJUBA LOXL2 URS00000B7E30_9606 MMP14 ALAS2 ACE CPT1A CXCR4 DDIT4 NGB CYGB IL1A MB ANG THBS1 MT-CYB AGTRAP EGLN2 BECN1 CITED2 NOL3 ADAM17 SOX4 HIF1A F7 ANGPTL4 APAF1 PIN1 MYOCD LIMD1 MYB CAT MT-ND2 PLAU LIF CLDN3 MT-ND1 RAD21 SCFD1 MTHFR TXN2 ACVRL1 TGFB3 LEP PPARA PGF PLOD1 HMOX2 HIF3A KCNJ8 CREBBP UCP2 XRCC1 BMP2 HSP90B1 TGFB2 MT-CO1 P2RX3 DPP4 ARNT TM9SF4 HSPG2 MMP2 CRYAB ADSL PLOD2 P2RX2 NOS2 HSD11B2 CAV3 TH EP300 CD38 TFRC FZD4 ANGPT2 MT-CO2 VEGFC TFAM NOS1 WDR83 CYP1A1 COMT LTA CD24 BIRC2 USF1 EDNRA SLC6A4 SCAP EPAS1 EGLN1 VEGFA KCNA5 PTK2B SRF CHRNA7 ALAD ITPR2 CAPN2 NF1 SMAD3 PDLIM1 MECP2 TGFBR3 PLAT KCNJ11 PENK WTIP PKLR ASCL2 ADIPOQ SOD2 ITPR1 ARNT2 VCAM1 AGER ADORA1 BNIP3 CIAO3 CBFA2T3 DRD2 NPPC TRPV4 EGR1 CASP9 TNF HK2 EPO SOD3 CXCL12 DIO3 REST NR4A2 CAV1 FOSL2 ERCC2 RYR2 TEK SLC2A1 ADM PSEN2 TLR2 VEGFD MT-ND4 VEGFB MT-ND5 KCNMA1