SCAP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045541Biological processnegative regulation of cholesterol biosynthetic process
GO_0008203Biological processcholesterol metabolic process
GO_0032868Biological processresponse to insulin
GO_0033552Biological processresponse to vitamin B3
GO_0042304Biological processregulation of fatty acid biosynthetic process
GO_0044255Biological processcellular lipid metabolic process
GO_0006955Biological processimmune response
GO_0032933Biological processSREBP signaling pathway
GO_0001666Biological processresponse to hypoxia
GO_0045540Biological processregulation of cholesterol biosynthetic process
GO_0045542Biological processpositive regulation of cholesterol biosynthetic process
GO_0090110Biological processCOPII-coated vesicle cargo loading
GO_0032936Cellular componentSREBP-SCAP complex
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0012507Cellular componentER to Golgi transport vesicle membrane
GO_0044877Molecular functionprotein-containing complex binding
GO_0051082Molecular functionunfolded protein binding
GO_0032934Molecular functionsterol binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSCAP
Protein nameSREBF chaperone
Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein)
SCAP protein
SynonymsPSEC0227
KIAA0199
DescriptionFUNCTION: Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity). Binds cholesterol via its SSD domain (By similarity). .

AccessionsC9JFY0
C9JQ35
F8W921
ENST00000495603.2
D6RA39
F8W9W7
ENST00000441517.6
F8WDP3
Q6PIX8
ENST00000265565.10 [Q12770-1]
ENST00000416208.5
ENST00000320017.10
ENST00000648151.1 [Q12770-1]
Q12770
ENST00000416847.5
ENST00000448217.2