Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 30 studies | 33% ± 15% | |
| capillary endothelial cell | 14 studies | 40% ± 21% | |
| endothelial cell of artery | 11 studies | 44% ± 20% | |
| vein endothelial cell | 8 studies | 40% ± 17% | |
| endothelial cell of lymphatic vessel | 6 studies | 24% ± 4% | |
| fibroblast | 6 studies | 20% ± 3% | |
| glomerular endothelial cell | 3 studies | 38% ± 1% | |
| endothelial cell of vascular tree | 3 studies | 37% ± 5% |
Insufficient scRNA-seq data for expression of ACVRL1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 4693.94 | 652 / 653 | 99% | 21.68 | 598 / 605 |
| breast | 100% | 5739.63 | 459 / 459 | 98% | 17.10 | 1100 / 1118 |
| intestine | 100% | 4465.91 | 965 / 966 | 98% | 35.66 | 518 / 527 |
| lung | 100% | 16111.62 | 578 / 578 | 98% | 18.40 | 1129 / 1155 |
| stomach | 98% | 2383.05 | 353 / 359 | 99% | 28.04 | 284 / 286 |
| kidney | 100% | 3367.04 | 89 / 89 | 95% | 35.81 | 856 / 901 |
| adrenal gland | 98% | 1919.17 | 253 / 258 | 93% | 22.68 | 215 / 230 |
| bladder | 100% | 3678.81 | 21 / 21 | 91% | 18.92 | 460 / 504 |
| prostate | 99% | 2827.48 | 243 / 245 | 90% | 9.28 | 450 / 502 |
| skin | 95% | 2499.48 | 1723 / 1809 | 93% | 14.11 | 440 / 472 |
| uterus | 100% | 4117.34 | 170 / 170 | 85% | 11.06 | 389 / 459 |
| pancreas | 76% | 986.56 | 250 / 328 | 100% | 25.01 | 178 / 178 |
| esophagus | 95% | 2998.98 | 1376 / 1445 | 81% | 9.83 | 148 / 183 |
| brain | 52% | 691.73 | 1369 / 2642 | 98% | 13.11 | 688 / 705 |
| adipose | 100% | 7119.19 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 32.12 | 29 / 29 |
| spleen | 100% | 4799.97 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.12 | 1 / 1 |
| heart | 96% | 2437.91 | 825 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 10.93 | 43 / 45 |
| ovary | 22% | 438.48 | 40 / 180 | 65% | 5.23 | 279 / 430 |
| liver | 6% | 66.33 | 14 / 226 | 80% | 7.53 | 324 / 406 |
| blood vessel | 84% | 1800.45 | 1124 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 84% | 9.20 | 67 / 80 |
| muscle | 83% | 1075.19 | 664 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 2% | 16.67 | 17 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0001525 | Biological process | angiogenesis |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0032924 | Biological process | activin receptor signaling pathway |
| GO_0071560 | Biological process | cellular response to transforming growth factor beta stimulus |
| GO_0060841 | Biological process | venous blood vessel development |
| GO_0030858 | Biological process | positive regulation of epithelial cell differentiation |
| GO_0001955 | Biological process | blood vessel maturation |
| GO_0001974 | Biological process | blood vessel remodeling |
| GO_0043535 | Biological process | regulation of blood vessel endothelial cell migration |
| GO_0071773 | Biological process | cellular response to BMP stimulus |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0060836 | Biological process | lymphatic endothelial cell differentiation |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0007507 | Biological process | heart development |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0045603 | Biological process | positive regulation of endothelial cell differentiation |
| GO_0007165 | Biological process | signal transduction |
| GO_0008217 | Biological process | regulation of blood pressure |
| GO_0007162 | Biological process | negative regulation of cell adhesion |
| GO_0032332 | Biological process | positive regulation of chondrocyte differentiation |
| GO_0051895 | Biological process | negative regulation of focal adhesion assembly |
| GO_0001946 | Biological process | lymphangiogenesis |
| GO_0060391 | Biological process | positive regulation of SMAD protein signal transduction |
| GO_0003203 | Biological process | endocardial cushion morphogenesis |
| GO_1903348 | Biological process | positive regulation of bicellular tight junction assembly |
| GO_0071363 | Biological process | cellular response to growth factor stimulus |
| GO_0045602 | Biological process | negative regulation of endothelial cell differentiation |
| GO_0043537 | Biological process | negative regulation of blood vessel endothelial cell migration |
| GO_0009953 | Biological process | dorsal/ventral pattern formation |
| GO_0061298 | Biological process | retina vasculature development in camera-type eye |
| GO_0002043 | Biological process | blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0001937 | Biological process | negative regulation of endothelial cell proliferation |
| GO_0061154 | Biological process | endothelial tube morphogenesis |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0001938 | Biological process | positive regulation of endothelial cell proliferation |
| GO_0035912 | Biological process | dorsal aorta morphogenesis |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0008015 | Biological process | blood circulation |
| GO_0030513 | Biological process | positive regulation of BMP signaling pathway |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0060840 | Biological process | artery development |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0010596 | Biological process | negative regulation of endothelial cell migration |
| GO_0045747 | Biological process | positive regulation of Notch signaling pathway |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0006275 | Biological process | regulation of DNA replication |
| GO_0035313 | Biological process | wound healing, spreading of epidermal cells |
| GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
| GO_0001936 | Biological process | regulation of endothelial cell proliferation |
| GO_0090500 | Biological process | endocardial cushion to mesenchymal transition |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0030308 | Biological process | negative regulation of cell growth |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0030425 | Cellular component | dendrite |
| GO_0009986 | Cellular component | cell surface |
| GO_0070724 | Cellular component | BMP receptor complex |
| GO_0098821 | Molecular function | BMP receptor activity |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0046332 | Molecular function | SMAD binding |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0048185 | Molecular function | activin binding |
| GO_0050431 | Molecular function | transforming growth factor beta binding |
| GO_0004675 | Molecular function | transmembrane receptor protein serine/threonine kinase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005024 | Molecular function | transforming growth factor beta receptor activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005025 | Molecular function | transforming growth factor beta receptor activity, type I |
| GO_0005515 | Molecular function | protein binding |
| GO_0016361 | Molecular function | activin receptor activity, type I |
| Gene name | ACVRL1 |
| Protein name | Activin A receptor like type 1 (Activin A receptor type II-like kinase 1 variant 3) (Activin A receptor type II-like kinase 1 variant 4) Serine/threonine-protein kinase receptor (EC 2.7.11.30) Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I) receptor protein serine/threonine kinase (EC 2.7.11.30) |
| Synonyms | hCG_37967 ALK1 ACVRLK1 |
| Description | FUNCTION: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. . |
| Accessions | ENST00000419526.6 ENST00000547400.6 H3BTZ2 ENST00000388922.9 A0A0S2Z310 P37023 F8W0N2 ENST00000552678.2 ENST00000551576.5 E7EN07 ENST00000550683.5 D9IPD9 G3V1W8 A0A0S2Z2Y4 ENST00000551576.6 |
