ITPR1 | OmnibusX

Name	Number of supported studies	Average coverage
B cell	16 studies	31% ± 15%	Explore
endothelial cell	16 studies	31% ± 16%	Explore
fibroblast	14 studies	29% ± 11%	Explore
naive B cell	14 studies	24% ± 7%	Explore
smooth muscle cell	13 studies	35% ± 12%	Explore
mast cell	13 studies	36% ± 13%	Explore
glutamatergic neuron	11 studies	57% ± 26%	Explore
pericyte	11 studies	28% ± 10%	Explore
microglial cell	9 studies	29% ± 14%	Explore
adipocyte	6 studies	29% ± 8%	Explore
T cell	6 studies	20% ± 4%	Explore
macrophage	6 studies	24% ± 4%	Explore
monocyte	6 studies	28% ± 6%	Explore
memory B cell	5 studies	20% ± 2%	Explore
dendritic cell	5 studies	23% ± 5%	Explore
endothelial cell of vascular tree	5 studies	20% ± 4%	Explore
endothelial cell of artery	5 studies	22% ± 3%	Explore
GABAergic neuron	5 studies	53% ± 17%	Explore
myeloid cell	4 studies	20% ± 3%	Explore
retinal pigment epithelial cell	4 studies	43% ± 14%	Explore
vein endothelial cell	4 studies	22% ± 4%	Explore
ciliated cell	4 studies	29% ± 11%	Explore
type II pneumocyte	4 studies	24% ± 5%	Explore
conventional dendritic cell	3 studies	20% ± 6%	Explore
neuron	3 studies	33% ± 11%	Explore
CD4-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	20% ± 2%	Explore
muscle cell	3 studies	45% ± 37%	Explore
astrocyte	3 studies	44% ± 21%	Explore
alveolar macrophage	3 studies	32% ± 7%	Explore
club cell	3 studies	24% ± 9%	Explore
endothelial cell of lymphatic vessel	3 studies	16% ± 1%	Explore
natural killer cell	3 studies	20% ± 1%	Explore
lymphocyte	3 studies	30% ± 7%	Explore
mesothelial cell	3 studies	29% ± 8%	Explore
plasmacytoid dendritic cell	3 studies	22% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	52% ± 16%	Explore
renal alpha-intercalated cell	3 studies	47% ± 22%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	37% ± 23%	Explore
lung	4 studies	21% ± 7%	Explore
heart	4 studies	22% ± 4%	Explore
kidney	3 studies	30% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	99%	7213.77	242 / 245	85%	7.79	426 / 502
breast	95%	5250.47	436 / 459	87%	10.16	978 / 1118
adrenal gland	98%	3999.88	254 / 258	81%	5.49	186 / 230
kidney	94%	3236.33	84 / 89	76%	6.14	689 / 901
thymus	100%	8348.19	652 / 653	71%	6.22	428 / 605
lung	99%	5044.63	575 / 578	64%	3.07	740 / 1155
brain	81%	7140.59	2130 / 2642	55%	3.28	387 / 705
bladder	100%	9859.43	21 / 21	31%	1.35	156 / 504
esophagus	87%	7818.22	1251 / 1445	44%	1.80	80 / 183
uterus	99%	11790.29	168 / 170	29%	2.16	134 / 459
stomach	74%	3030.03	265 / 359	38%	1.69	110 / 286
ovary	100%	9027.16	180 / 180	12%	0.52	52 / 430
intestine	87%	4937.80	838 / 966	24%	0.93	124 / 527
blood vessel	100%	15968.80	1335 / 1335	0%	0	0 / 0
skin	43%	1012.99	782 / 1809	55%	3.10	261 / 472
spleen	98%	2905.08	235 / 241	0%	0	0 / 0
adipose	96%	3295.35	1152 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	7.29	26 / 29
heart	75%	1879.71	650 / 861	0%	0	0 / 0
pancreas	3%	59.35	11 / 328	60%	2.50	106 / 178
tonsil	0%	0	0 / 0	44%	1.36	20 / 45
peripheral blood	24%	1661.85	221 / 929	0%	0	0 / 0
liver	7%	124.93	16 / 226	11%	0.66	46 / 406
muscle	8%	141.30	61 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0051480	Biological process	regulation of cytosolic calcium ion concentration
GO_0070059	Biological process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0050882	Biological process	voluntary musculoskeletal movement
GO_0009791	Biological process	post-embryonic development
GO_0019722	Biological process	calcium-mediated signaling
GO_0099566	Biological process	regulation of postsynaptic cytosolic calcium ion concentration
GO_0007207	Biological process	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
GO_0007165	Biological process	signal transduction
GO_1990806	Biological process	ligand-gated ion channel signaling pathway
GO_1903514	Biological process	release of sequestered calcium ion into cytosol by endoplasmic reticulum
GO_0051209	Biological process	release of sequestered calcium ion into cytosol
GO_0032024	Biological process	positive regulation of insulin secretion
GO_0042045	Biological process	epithelial fluid transport
GO_0010506	Biological process	regulation of autophagy
GO_0050849	Biological process	negative regulation of calcium-mediated signaling
GO_0001666	Biological process	response to hypoxia
GO_0000902	Biological process	cell morphogenesis
GO_0007338	Biological process	single fertilization
GO_0036444	Biological process	calcium import into the mitochondrion
GO_0006816	Biological process	calcium ion transport
GO_0032469	Biological process	endoplasmic reticulum calcium ion homeostasis
GO_0099105	Biological process	ion channel modulating, G protein-coupled receptor signaling pathway
GO_0051289	Biological process	protein homotetramerization
GO_0005730	Cellular component	nucleolus
GO_0030667	Cellular component	secretory granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0098685	Cellular component	Schaffer collateral - CA1 synapse
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0031088	Cellular component	platelet dense granule membrane
GO_0031094	Cellular component	platelet dense tubular network
GO_0005955	Cellular component	calcineurin complex
GO_0005637	Cellular component	nuclear inner membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0016529	Cellular component	sarcoplasmic reticulum
GO_0014069	Cellular component	postsynaptic density
GO_0030658	Cellular component	transport vesicle membrane
GO_0031095	Cellular component	platelet dense tubular network membrane
GO_0098695	Molecular function	inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
GO_0015085	Molecular function	calcium ion transmembrane transporter activity
GO_0019904	Molecular function	protein domain specific binding
GO_0035091	Molecular function	phosphatidylinositol binding
GO_0070679	Molecular function	inositol 1,4,5 trisphosphate binding
GO_0005524	Molecular function	ATP binding
GO_0019855	Molecular function	calcium channel inhibitor activity
GO_0005220	Molecular function	inositol 1,4,5-trisphosphate-gated calcium channel activity
GO_0015278	Molecular function	intracellularly gated calcium channel activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ITPR1
Protein name	Inositol 1,4,5-trisphosphate receptor Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) Inositol 1,4,5-trisphosphate receptor type 1
Synonyms	INSP3R1
Description	FUNCTION: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate . Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). . FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. . FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. . FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. . FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. . FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. . FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. . FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. . FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. .
Accessions	ENST00000648038.1 ENST00000649139.1 A0A3B3IU13 Q14643 B7ZMI3 A0A3B3IRP0 A0A3B3ISE3 ENST00000649015.2 [Q14643-1] ENST00000478515.2 A0A3B3IS59 A0A3B3ITQ1 ENST00000357086.10 [Q14643-3] ENST00000467056.6 A0A3B3ITU8 ENST00000354582.12 A0A3B3IRT5 ENST00000647685.1 A0A3B3IU04 A0A3B3ITM1 ENST00000456211.8 [Q14643-4] ENST00000648212.1 A0A3B3ITQ4 ENST00000648016.1 ENST00000649051.1 ENST00000650294.1 ENST00000648266.1 ENST00000544951.6 ENST00000649908.1 ENST00000648431.1 A0A3F2YNW8 ENST00000648309.1 [Q14643-5] ENST00000302640.13 ENST00000648564.1 A0A3B3ISR4 ENST00000443694.5 [Q14643-2] A0A8C8KBY2 ENST00000649414.1 ENST00000648390.1 A0A3B3ITM6 A0A3B3IU05

ITPR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review