Insufficient scRNA-seq data for expression of EPO at single-cell level.
Insufficient scRNA-seq data for expression of EPO at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 97% | 33.54 | 237 / 245 | 46% | 1.43 | 231 / 502 |
liver | 100% | 1520.93 | 226 / 226 | 36% | 6.05 | 147 / 406 |
kidney | 87% | 180.03 | 77 / 89 | 32% | 13.80 | 285 / 901 |
uterus | 97% | 95.52 | 165 / 170 | 17% | 0.47 | 80 / 459 |
pancreas | 100% | 269.27 | 328 / 328 | 9% | 0.24 | 16 / 178 |
breast | 75% | 7.67 | 345 / 459 | 20% | 1.98 | 223 / 1118 |
esophagus | 63% | 5.87 | 914 / 1445 | 30% | 2.11 | 54 / 183 |
ovary | 88% | 12.30 | 159 / 180 | 0% | 0.01 | 2 / 430 |
skin | 80% | 17.62 | 1452 / 1809 | 3% | 0.08 | 14 / 472 |
brain | 74% | 8.77 | 1949 / 2642 | 7% | 0.25 | 52 / 705 |
bladder | 67% | 7.57 | 14 / 21 | 6% | 0.29 | 32 / 504 |
lung | 65% | 6.57 | 378 / 578 | 6% | 0.13 | 66 / 1155 |
adipose | 69% | 6.07 | 835 / 1204 | 0% | 0 | 0 / 0 |
intestine | 66% | 5.98 | 641 / 966 | 2% | 0.08 | 13 / 527 |
spleen | 68% | 6.17 | 164 / 241 | 0% | 0 | 0 / 0 |
adrenal gland | 46% | 3.21 | 118 / 258 | 12% | 0.84 | 28 / 230 |
blood vessel | 56% | 4.46 | 741 / 1335 | 0% | 0 | 0 / 0 |
thymus | 53% | 3.78 | 345 / 653 | 0% | 0 | 0 / 605 |
stomach | 41% | 2.80 | 147 / 359 | 1% | 0.01 | 3 / 286 |
heart | 42% | 10.27 | 360 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 34% | 5.24 | 319 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 20% | 0.51 | 9 / 45 |
muscle | 14% | 0.74 | 115 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0042531 | Biological process | positive regulation of tyrosine phosphorylation of STAT protein |
GO_0033574 | Biological process | response to testosterone |
GO_0042104 | Biological process | positive regulation of activated T cell proliferation |
GO_1902251 | Biological process | negative regulation of erythrocyte apoptotic process |
GO_0006953 | Biological process | acute-phase response |
GO_0043627 | Biological process | response to estrogen |
GO_0043249 | Biological process | erythrocyte maturation |
GO_0010976 | Biological process | positive regulation of neuron projection development |
GO_0033028 | Biological process | myeloid cell apoptotic process |
GO_0009651 | Biological process | response to salt stress |
GO_0051602 | Biological process | response to electrical stimulus |
GO_0042541 | Biological process | hemoglobin biosynthetic process |
GO_0007165 | Biological process | signal transduction |
GO_0048678 | Biological process | response to axon injury |
GO_0038162 | Biological process | erythropoietin-mediated signaling pathway |
GO_0033189 | Biological process | response to vitamin A |
GO_0070555 | Biological process | response to interleukin-1 |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0010523 | Biological process | negative regulation of calcium ion transport into cytosol |
GO_0071548 | Biological process | response to dexamethasone |
GO_0030218 | Biological process | erythrocyte differentiation |
GO_0055093 | Biological process | response to hyperoxia |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0001666 | Biological process | response to hypoxia |
GO_0008015 | Biological process | blood circulation |
GO_2001258 | Biological process | negative regulation of cation channel activity |
GO_0046579 | Biological process | positive regulation of Ras protein signal transduction |
GO_1902219 | Biological process | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0071474 | Biological process | cellular hyperosmotic response |
GO_0045666 | Biological process | positive regulation of neuron differentiation |
GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
GO_0032496 | Biological process | response to lipopolysaccharide |
GO_0007566 | Biological process | embryo implantation |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0009986 | Cellular component | cell surface |
GO_0044297 | Cellular component | cell body |
GO_0005179 | Molecular function | hormone activity |
GO_0005125 | Molecular function | cytokine activity |
GO_0005128 | Molecular function | erythropoietin receptor binding |
GO_0030295 | Molecular function | protein kinase activator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | EPO |
Protein name | Erythropoietin Erythropoietin (Epoetin) |
Synonyms | hCG_20446 |
Description | FUNCTION: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. . FUNCTION: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. . FUNCTION: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. . |
Accessions | ENST00000252723.3 B7ZKK5 G9JKG7 P01588 |