ADA | OmnibusX

Name	Number of supported studies	Average coverage
plasmacytoid dendritic cell	13 studies	35% ± 17%	Explore
non-classical monocyte	12 studies	28% ± 12%	Explore
CD8-positive, alpha-beta T cell	7 studies	25% ± 8%	Explore
natural killer cell	6 studies	21% ± 2%	Explore
CD4-positive, alpha-beta T cell	5 studies	27% ± 9%	Explore
pro-B cell	5 studies	48% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	18% ± 1%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	22% ± 3%	Explore
B cell	3 studies	29% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	26% ± 8%	Explore
T cell	3 studies	25% ± 8%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ADA at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	2531.09	359 / 359	98%	15.29	279 / 286
skin	100%	809.74	1803 / 1809	98%	17.36	462 / 472
esophagus	100%	789.81	1445 / 1445	97%	18.01	178 / 183
breast	100%	1074.64	458 / 459	96%	10.46	1073 / 1118
uterus	99%	485.01	168 / 170	96%	22.91	442 / 459
lung	100%	755.96	576 / 578	95%	18.41	1092 / 1155
intestine	99%	612.88	954 / 966	95%	15.03	499 / 527
thymus	100%	658.09	650 / 653	90%	67.11	542 / 605
bladder	95%	548.86	20 / 21	89%	17.79	448 / 504
pancreas	84%	226.19	275 / 328	94%	13.46	168 / 178
kidney	84%	285.85	75 / 89	85%	10.21	768 / 901
ovary	70%	210.34	126 / 180	98%	11.33	420 / 430
brain	68%	249.81	1805 / 2642	92%	9.82	646 / 705
adrenal gland	100%	529.69	258 / 258	52%	4.21	119 / 230
liver	62%	169.85	140 / 226	82%	6.74	332 / 406
prostate	96%	500.27	236 / 245	30%	1.43	151 / 502
adipose	100%	1489.38	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	179.12	29 / 29
spleen	100%	1504.94	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.22	45 / 45
ureter	0%	0	0 / 0	100%	8.35	1 / 1
heart	100%	1005.07	860 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	8.63	77 / 80
muscle	94%	312.20	756 / 803	0%	0	0 / 0
peripheral blood	93%	1793.83	861 / 929	0%	0	0 / 0
blood vessel	85%	427.80	1131 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002906	Biological process	negative regulation of mature B cell apoptotic process
GO_0006939	Biological process	smooth muscle contraction
GO_0050862	Biological process	positive regulation of T cell receptor signaling pathway
GO_0044209	Biological process	AMP salvage
GO_0006805	Biological process	xenobiotic metabolic process
GO_0002686	Biological process	negative regulation of leukocyte migration
GO_0050850	Biological process	positive regulation of calcium-mediated signaling
GO_0019722	Biological process	calcium-mediated signaling
GO_0046103	Biological process	inosine biosynthetic process
GO_0002467	Biological process	germinal center formation
GO_0006196	Biological process	AMP catabolic process
GO_0006157	Biological process	deoxyadenosine catabolic process
GO_0070256	Biological process	negative regulation of mucus secretion
GO_0001829	Biological process	trophectodermal cell differentiation
GO_0000255	Biological process	allantoin metabolic process
GO_0048566	Biological process	embryonic digestive tract development
GO_0014074	Biological process	response to purine-containing compound
GO_0001889	Biological process	liver development
GO_0007155	Biological process	cell adhesion
GO_0046085	Biological process	adenosine metabolic process
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0032261	Biological process	purine nucleotide salvage
GO_0043103	Biological process	hypoxanthine salvage
GO_0048541	Biological process	Peyer's patch development
GO_0070242	Biological process	thymocyte apoptotic process
GO_0001890	Biological process	placenta development
GO_0060169	Biological process	negative regulation of adenosine receptor signaling pathway
GO_0032263	Biological process	GMP salvage
GO_0033632	Biological process	regulation of cell-cell adhesion mediated by integrin
GO_0033077	Biological process	T cell differentiation in thymus
GO_0043084	Biological process	penile erection
GO_0046059	Biological process	dAMP catabolic process
GO_0002314	Biological process	germinal center B cell differentiation
GO_0043605	Biological process	amide catabolic process
GO_0045987	Biological process	positive regulation of smooth muscle contraction
GO_0050728	Biological process	negative regulation of inflammatory response
GO_0002901	Biological process	mature B cell apoptotic process
GO_0050900	Biological process	leukocyte migration
GO_0001666	Biological process	response to hypoxia
GO_0043101	Biological process	purine-containing compound salvage
GO_0030890	Biological process	positive regulation of B cell proliferation
GO_0046111	Biological process	xanthine biosynthetic process
GO_0006154	Biological process	adenosine catabolic process
GO_0060407	Biological process	negative regulation of penile erection
GO_0070244	Biological process	negative regulation of thymocyte apoptotic process
GO_0033089	Biological process	positive regulation of T cell differentiation in thymus
GO_0042100	Biological process	B cell proliferation
GO_0070254	Biological process	mucus secretion
GO_0046632	Biological process	alpha-beta T cell differentiation
GO_0046638	Biological process	positive regulation of alpha-beta T cell differentiation
GO_0002636	Biological process	positive regulation of germinal center formation
GO_0042110	Biological process	T cell activation
GO_0010460	Biological process	positive regulation of heart rate
GO_0048286	Biological process	lung alveolus development
GO_0046061	Biological process	dATP catabolic process
GO_0060205	Cellular component	cytoplasmic vesicle lumen
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005764	Cellular component	lysosome
GO_0009986	Cellular component	cell surface
GO_0005829	Cellular component	cytosol
GO_0070161	Cellular component	anchoring junction
GO_0019239	Molecular function	deaminase activity
GO_0008270	Molecular function	zinc ion binding
GO_0046936	Molecular function	2'-deoxyadenosine deaminase activity
GO_0005515	Molecular function	protein binding
GO_0004000	Molecular function	adenosine deaminase activity

IV. Literature review

[source]

Gene name	ADA
Protein name	Adenosine deaminase Mutant adenosine deaminase adenosine deaminase (EC 3.5.4.4) Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) Adenosine deaminase (EC 3.5.4.4)
Synonyms	hCG_38105 ADA1
Description	FUNCTION: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine . Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 . Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion . Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation . Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change . Stimulates plasminogen activation . Plays a role in male fertility . Plays a protective role in early postimplantation embryonic development (By similarity). .
Accessions	ENST00000537820.2 ENST00000695949.1 ENST00000696082.1 ENST00000695956.1 A0A0S2Z3T6 A0A8Q3SIC0 A0A8Q3SIG8 F5GXW0 ENST00000695891.1 X5D767 ENST00000696006.1 A0A8Q3WKY2 A0A8Q3WL01 A0A8Q3WKZ1 ENST00000695957.1 ENST00000695992.1 ENST00000696080.1 ENST00000695994.1 A0A8Q3WKW4 A0A8Q3SIC7 A0A8Q3SIA9 ENST00000696078.1 ENST00000696105.1 A0A8Q3WKZ4 A0A8Q3SI46 ENST00000695927.1 A0A8Q3WLJ0 A0A8Q3WM09 ENST00000696065.1 ENST00000696038.1 ENST00000696017.1 ENST00000696077.1 ENST00000695889.1 A0A8Q3SIE4 ENST00000539235.6 A0A8Q3SIH0 F5GYD4 ENST00000696034.1 ENST00000696058.1 A0A8Q3SJ63 ENST00000695991.1 ENST00000372874.9 P00813 A0A8Q3SJ25 ENST00000695995.1 A0A8Q3WM84 A0A8Q3WL06 A0A8Q3SI64 A0A8Q3SI69 A0A8Q3WKX8 Q16073 ENST00000696079.1 ENST00000696076.1 ENST00000696061.1 ENST00000696104.1 ENST00000696064.1 ENST00000696007.1 F5GWI4 A0A8Q3WL32 A0A0S2Z3B9 A0A8Q3SJ57 ENST00000696075.1 ENST00000696060.1 ENST00000536532.6 ENST00000536076.2 ENST00000696059.1 A0A8Q3WKZ6 A0A0S2Z381 A0A8Q3WKX5 ENST00000696063.1 ENST00000696062.1 A0A8Q3WKZ9 A0A8Q3SJ50 ENST00000695993.1 ENST00000696005.1 A0A8Q3WKZ5 A0A8Q3WM58 A0A8Q3WLK2

ADA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review