germinal center B cell differentiation

I. Literature review

[source]
Namegerminal center B cell differentiation
IDGO_0002314
collection_id

Biological process

Exact synonym

germinal center B lymphocyte differentiation, germinal center B-cell differentiation, germinal center B-lymphocyte differentiation

Description

The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).

Related synonym

germinal center B cell development

Comment

Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.

External URL
Genes