PHF14 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	41 studies	33% ± 14%	Explore
fibroblast	31 studies	32% ± 11%	Explore
smooth muscle cell	21 studies	28% ± 9%	Explore
astrocyte	19 studies	41% ± 18%	Explore
pericyte	19 studies	30% ± 14%	Explore
B cell	18 studies	23% ± 7%	Explore
oligodendrocyte precursor cell	16 studies	49% ± 18%	Explore
endothelial cell of lymphatic vessel	15 studies	30% ± 11%	Explore
oligodendrocyte	15 studies	37% ± 14%	Explore
microglial cell	14 studies	36% ± 13%	Explore
T cell	13 studies	21% ± 7%	Explore
glutamatergic neuron	13 studies	60% ± 24%	Explore
capillary endothelial cell	12 studies	24% ± 6%	Explore
epithelial cell	12 studies	36% ± 18%	Explore
natural killer cell	11 studies	20% ± 4%	Explore
GABAergic neuron	11 studies	60% ± 23%	Explore
connective tissue cell	11 studies	35% ± 14%	Explore
macrophage	11 studies	32% ± 14%	Explore
basal cell	11 studies	31% ± 16%	Explore
CD4-positive, alpha-beta T cell	10 studies	21% ± 6%	Explore
CD8-positive, alpha-beta T cell	10 studies	21% ± 6%	Explore
myofibroblast cell	10 studies	37% ± 12%	Explore
neuron	10 studies	55% ± 18%	Explore
endothelial cell of artery	10 studies	22% ± 6%	Explore
vein endothelial cell	10 studies	29% ± 12%	Explore
adipocyte	10 studies	34% ± 10%	Explore
mesothelial cell	9 studies	34% ± 12%	Explore
type I pneumocyte	9 studies	27% ± 7%	Explore
ciliated cell	9 studies	26% ± 8%	Explore
plasmacytoid dendritic cell	9 studies	25% ± 8%	Explore
abnormal cell	8 studies	26% ± 11%	Explore
amacrine cell	8 studies	44% ± 17%	Explore
endothelial cell of vascular tree	8 studies	27% ± 13%	Explore
progenitor cell	7 studies	38% ± 15%	Explore
interneuron	7 studies	68% ± 21%	Explore
type II pneumocyte	7 studies	28% ± 6%	Explore
myeloid cell	7 studies	23% ± 6%	Explore
memory B cell	6 studies	18% ± 2%	Explore
naive B cell	6 studies	20% ± 5%	Explore
retina horizontal cell	6 studies	42% ± 17%	Explore
retinal cone cell	6 studies	31% ± 9%	Explore
dendritic cell	6 studies	24% ± 8%	Explore
mast cell	6 studies	24% ± 5%	Explore
regulatory T cell	6 studies	19% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	18% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	22% ± 6%	Explore
retinal bipolar neuron	5 studies	37% ± 14%	Explore
retinal ganglion cell	5 studies	41% ± 19%	Explore
brush cell	5 studies	23% ± 7%	Explore
immature B cell	5 studies	29% ± 15%	Explore
lymphocyte	5 studies	27% ± 7%	Explore
Mueller cell	5 studies	37% ± 12%	Explore
goblet cell	5 studies	31% ± 9%	Explore
club cell	5 studies	29% ± 9%	Explore
hematopoietic precursor cell	4 studies	35% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	18% ± 2%	Explore
conventional dendritic cell	4 studies	28% ± 16%	Explore
glial cell	4 studies	37% ± 17%	Explore
granule cell	4 studies	52% ± 8%	Explore
precursor B cell	4 studies	31% ± 6%	Explore
pro-B cell	4 studies	32% ± 6%	Explore
retinal rod cell	4 studies	25% ± 12%	Explore
respiratory goblet cell	4 studies	31% ± 13%	Explore
hepatocyte	4 studies	46% ± 12%	Explore
hematopoietic stem cell	4 studies	23% ± 11%	Explore
enteroendocrine cell	4 studies	33% ± 11%	Explore
leukocyte	4 studies	27% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	19% ± 4%	Explore
T follicular helper cell	4 studies	16% ± 0%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	23% ± 11%	Explore
non-classical monocyte	3 studies	21% ± 4%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	50% ± 5%	Explore
neural crest cell	3 studies	39% ± 4%	Explore
gamma-delta T cell	3 studies	38% ± 23%	Explore
GABAergic interneuron	3 studies	63% ± 3%	Explore
GABAergic amacrine cell	3 studies	55% ± 16%	Explore
OFF-bipolar cell	3 studies	47% ± 19%	Explore
ON-bipolar cell	3 studies	38% ± 16%	Explore
glycinergic amacrine cell	3 studies	53% ± 16%	Explore
rod bipolar cell	3 studies	27% ± 4%	Explore
secretory cell	3 studies	23% ± 5%	Explore
neural progenitor cell	3 studies	44% ± 17%	Explore
ependymal cell	3 studies	44% ± 18%	Explore
granulocyte monocyte progenitor cell	3 studies	28% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	40% ± 17%	Explore
intestinal crypt stem cell	3 studies	23% ± 3%	Explore
adventitial cell	3 studies	23% ± 4%	Explore
alveolar macrophage	3 studies	27% ± 6%	Explore
chondrocyte	3 studies	34% ± 4%	Explore
monocyte	3 studies	30% ± 2%	Explore
transit amplifying cell	3 studies	39% ± 27%	Explore
cardiac muscle cell	3 studies	16% ± 1%	Explore
mucus secreting cell	3 studies	28% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	48% ± 21%	Explore
lung	10 studies	28% ± 9%	Explore
eye	8 studies	32% ± 16%	Explore
intestine	6 studies	31% ± 15%	Explore
heart	5 studies	22% ± 3%	Explore
peripheral blood	4 studies	25% ± 12%	Explore
liver	4 studies	34% ± 13%	Explore
adipose	4 studies	38% ± 18%	Explore
kidney	3 studies	23% ± 5%	Explore
breast	3 studies	19% ± 2%	Explore
lymph node	3 studies	18% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1627.66	1445 / 1445	100%	19.24	183 / 183
prostate	100%	1875.89	245 / 245	100%	13.20	502 / 502
breast	100%	1829.22	459 / 459	100%	16.25	1117 / 1118
brain	100%	1761.70	2641 / 2642	100%	15.58	704 / 705
bladder	100%	1872.95	21 / 21	100%	12.24	503 / 504
uterus	100%	2231.86	170 / 170	100%	11.90	458 / 459
lung	100%	1488.01	577 / 578	100%	13.21	1154 / 1155
stomach	100%	1311.30	359 / 359	100%	14.88	285 / 286
intestine	100%	1710.46	966 / 966	99%	13.20	520 / 527
thymus	100%	1671.92	653 / 653	98%	9.59	595 / 605
pancreas	99%	922.29	326 / 328	99%	10.08	176 / 178
liver	100%	1019.02	226 / 226	98%	7.32	398 / 406
kidney	100%	1379.40	89 / 89	95%	8.57	859 / 901
ovary	100%	2235.08	180 / 180	95%	9.15	408 / 430
skin	100%	1782.92	1808 / 1809	95%	13.99	448 / 472
adrenal gland	100%	1768.79	258 / 258	94%	8.25	217 / 230
adipose	100%	1756.00	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1750.45	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	11.10	29 / 29
spleen	100%	1633.37	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	9.89	45 / 45
heart	99%	827.58	850 / 861	0%	0	0 / 0
muscle	99%	872.55	792 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	69%	4.56	55 / 80
peripheral blood	65%	683.62	602 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0060916	Biological process	mesenchymal cell proliferation involved in lung development
GO_0002314	Biological process	germinal center B cell differentiation
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0072201	Biological process	negative regulation of mesenchymal cell proliferation
GO_2000584	Biological process	negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
GO_2000791	Biological process	negative regulation of mesenchymal cell proliferation involved in lung development
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0010463	Biological process	mesenchymal cell proliferation
GO_0048286	Biological process	lung alveolus development
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0005694	Cellular component	chromosome
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0140566	Molecular function	histone reader activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0042393	Molecular function	histone binding

IV. Literature review

[source]

Gene name	PHF14
Protein name	Alternative protein PHF14 PHD finger protein 14
Synonyms	KIAA0783
Description	FUNCTION: Histone-binding protein . Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). .
Accessions	B4DG57 ENST00000642461.1 ENST00000403050.7 [O94880-1] O94880 E5RHD5 ENST00000634607.2 [O94880-3] ENST00000521747.5 ENST00000423760.6 L8E7B7

PHF14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review