Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 15 studies | 26% ± 14% | |
| pericyte | 10 studies | 37% ± 14% | |
| endothelial cell | 8 studies | 26% ± 12% | |
| endothelial cell of vascular tree | 7 studies | 37% ± 12% | |
| endothelial cell of artery | 6 studies | 24% ± 8% | |
| vein endothelial cell | 6 studies | 32% ± 14% | |
| smooth muscle cell | 6 studies | 38% ± 11% | |
| capillary endothelial cell | 4 studies | 19% ± 4% |
Insufficient scRNA-seq data for expression of IL6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 95% | 3672.00 | 550 / 578 | 78% | 14.08 | 903 / 1155 |
| breast | 84% | 1125.07 | 386 / 459 | 36% | 3.53 | 399 / 1118 |
| esophagus | 48% | 426.05 | 688 / 1445 | 65% | 9.49 | 119 / 183 |
| stomach | 41% | 512.27 | 147 / 359 | 64% | 8.57 | 182 / 286 |
| intestine | 50% | 469.10 | 480 / 966 | 55% | 7.50 | 289 / 527 |
| bladder | 43% | 458.48 | 9 / 21 | 59% | 9.15 | 295 / 504 |
| thymus | 54% | 472.22 | 352 / 653 | 33% | 4.69 | 202 / 605 |
| adipose | 87% | 3815.27 | 1046 / 1204 | 0% | 0 | 0 / 0 |
| prostate | 36% | 544.76 | 89 / 245 | 44% | 5.00 | 222 / 502 |
| skin | 45% | 264.05 | 820 / 1809 | 35% | 2.59 | 165 / 472 |
| uterus | 25% | 144.21 | 43 / 170 | 45% | 10.62 | 207 / 459 |
| kidney | 29% | 259.62 | 26 / 89 | 34% | 8.78 | 304 / 901 |
| pancreas | 9% | 31.38 | 30 / 328 | 50% | 6.53 | 89 / 178 |
| ovary | 19% | 175.84 | 35 / 180 | 38% | 3.21 | 165 / 430 |
| blood vessel | 52% | 920.96 | 694 / 1335 | 0% | 0 | 0 / 0 |
| heart | 51% | 918.76 | 437 / 861 | 0% | 0 | 0 / 0 |
| spleen | 50% | 113.80 | 121 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 49% | 3.43 | 22 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 48% | 7.73 | 14 / 29 |
| adrenal gland | 24% | 350.41 | 62 / 258 | 24% | 7.65 | 55 / 230 |
| brain | 19% | 83.88 | 503 / 2642 | 24% | 3.07 | 169 / 705 |
| muscle | 19% | 101.24 | 156 / 803 | 0% | 0 | 0 / 0 |
| liver | 9% | 62.63 | 21 / 226 | 9% | 0.81 | 35 / 406 |
| peripheral blood | 2% | 17.25 | 21 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0032722 | Biological process | positive regulation of chemokine production |
| GO_0090594 | Biological process | inflammatory response to wounding |
| GO_0050796 | Biological process | regulation of insulin secretion |
| GO_0006954 | Biological process | inflammatory response |
| GO_0002384 | Biological process | hepatic immune response |
| GO_0002639 | Biological process | positive regulation of immunoglobulin production |
| GO_0061888 | Biological process | regulation of astrocyte activation |
| GO_2000635 | Biological process | negative regulation of primary miRNA processing |
| GO_1902512 | Biological process | positive regulation of apoptotic DNA fragmentation |
| GO_0050829 | Biological process | defense response to Gram-negative bacterium |
| GO_0032966 | Biological process | negative regulation of collagen biosynthetic process |
| GO_0014823 | Biological process | response to activity |
| GO_2000553 | Biological process | positive regulation of T-helper 2 cell cytokine production |
| GO_0006959 | Biological process | humoral immune response |
| GO_0030168 | Biological process | platelet activation |
| GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
| GO_0002446 | Biological process | neutrophil mediated immunity |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0002675 | Biological process | positive regulation of acute inflammatory response |
| GO_1904996 | Biological process | positive regulation of leukocyte adhesion to vascular endothelial cell |
| GO_0032740 | Biological process | positive regulation of interleukin-17 production |
| GO_0070301 | Biological process | cellular response to hydrogen peroxide |
| GO_0010573 | Biological process | vascular endothelial growth factor production |
| GO_1903978 | Biological process | regulation of microglial cell activation |
| GO_0042102 | Biological process | positive regulation of T cell proliferation |
| GO_1904894 | Biological process | positive regulation of receptor signaling pathway via STAT |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0006953 | Biological process | acute-phase response |
| GO_0060252 | Biological process | positive regulation of glial cell proliferation |
| GO_0031175 | Biological process | neuron projection development |
| GO_0032745 | Biological process | positive regulation of interleukin-21 production |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0045599 | Biological process | negative regulation of fat cell differentiation |
| GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
| GO_1900017 | Biological process | positive regulation of cytokine production involved in inflammatory response |
| GO_0045765 | Biological process | regulation of angiogenesis |
| GO_0032494 | Biological process | response to peptidoglycan |
| GO_2000660 | Biological process | negative regulation of interleukin-1-mediated signaling pathway |
| GO_0097421 | Biological process | liver regeneration |
| GO_0050830 | Biological process | defense response to Gram-positive bacterium |
| GO_0010574 | Biological process | regulation of vascular endothelial growth factor production |
| GO_0061470 | Biological process | T follicular helper cell differentiation |
| GO_0032757 | Biological process | positive regulation of interleukin-8 production |
| GO_0072574 | Biological process | hepatocyte proliferation |
| GO_0045727 | Biological process | positive regulation of translation |
| GO_0071222 | Biological process | cellular response to lipopolysaccharide |
| GO_2000676 | Biological process | positive regulation of type B pancreatic cell apoptotic process |
| GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
| GO_0032755 | Biological process | positive regulation of interleukin-6 production |
| GO_0042531 | Biological process | positive regulation of tyrosine phosphorylation of STAT protein |
| GO_0150077 | Biological process | regulation of neuroinflammatory response |
| GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
| GO_0048661 | Biological process | positive regulation of smooth muscle cell proliferation |
| GO_0033138 | Biological process | positive regulation of peptidyl-serine phosphorylation |
| GO_0070091 | Biological process | glucagon secretion |
| GO_0001781 | Biological process | neutrophil apoptotic process |
| GO_0032731 | Biological process | positive regulation of interleukin-1 beta production |
| GO_0002314 | Biological process | germinal center B cell differentiation |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0072540 | Biological process | T-helper 17 cell lineage commitment |
| GO_0010575 | Biological process | positive regulation of vascular endothelial growth factor production |
| GO_0032682 | Biological process | negative regulation of chemokine production |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0150078 | Biological process | positive regulation of neuroinflammatory response |
| GO_0010888 | Biological process | negative regulation of lipid storage |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0046427 | Biological process | positive regulation of receptor signaling pathway via JAK-STAT |
| GO_0002690 | Biological process | positive regulation of leukocyte chemotaxis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0050871 | Biological process | positive regulation of B cell activation |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0090091 | Biological process | positive regulation of extracellular matrix disassembly |
| GO_0045779 | Biological process | negative regulation of bone resorption |
| GO_0051607 | Biological process | defense response to virus |
| GO_0032733 | Biological process | positive regulation of interleukin-10 production |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0098586 | Biological process | cellular response to virus |
| GO_0070050 | Biological process | neuron cellular homeostasis |
| GO_0070102 | Biological process | interleukin-6-mediated signaling pathway |
| GO_0051384 | Biological process | response to glucocorticoid |
| GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
| GO_0035633 | Biological process | maintenance of blood-brain barrier |
| GO_1901731 | Biological process | positive regulation of platelet aggregation |
| GO_0010718 | Biological process | positive regulation of epithelial to mesenchymal transition |
| GO_0070092 | Biological process | regulation of glucagon secretion |
| GO_0031018 | Biological process | endocrine pancreas development |
| GO_0002548 | Biological process | monocyte chemotaxis |
| GO_0050768 | Biological process | negative regulation of neurogenesis |
| GO_0042593 | Biological process | glucose homeostasis |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005896 | Cellular component | interleukin-6 receptor complex |
| GO_0005125 | Molecular function | cytokine activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0005138 | Molecular function | interleukin-6 receptor binding |
| Gene name | IL6 |
| Protein name | Truncated interleukin 6 Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2) Interleukin-6 |
| Synonyms | tcag7.131 IFNB2 hCG_38231 |
| Description | FUNCTION: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable). .; FUNCTION: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (Probable). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity). .; FUNCTION: Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability . Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF . Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance . 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis (By similarity). Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (Probable). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection . Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity). . |
| Accessions | ENST00000426291.5 B5MCZ3 A0A1C9J7T5 ENST00000407492.5 B4DNV3 B5MC14 P05231 ENST00000401651.5 A0A1C9J7T7 A0A1C9J7T8 C9J5B0 Q75MH2 B5MC21 ENST00000258743.10 ENST00000401630.7 A0A1C9J7V0 A0A1C9J7V2 ENST00000404625.5 A0A8Q3SJL1 ENST00000485300.1 ENST00000406575.1 A0A1C9J7U0 |
