I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| T follicular helper cell | 3 studies | 18% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| T follicular helper cell | 3 studies | 18% ± 2% |
Insufficient scRNA-seq data for expression of IL21 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lymph node | 0% | 0 | 0 / 0 | 31% | 1.77 | 9 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 11% | 0.19 | 5 / 45 |
| lung | 3% | 0.15 | 18 / 578 | 6% | 0.10 | 72 / 1155 |
| intestine | 5% | 0.36 | 47 / 966 | 2% | 0.04 | 13 / 527 |
| skin | 0% | 0.00 | 1 / 1809 | 6% | 0.09 | 27 / 472 |
| stomach | 1% | 0.03 | 3 / 359 | 5% | 0.08 | 14 / 286 |
| breast | 0% | 0.01 | 1 / 459 | 5% | 0.10 | 57 / 1118 |
| thymus | 2% | 0.22 | 14 / 653 | 3% | 0.05 | 18 / 605 |
| spleen | 4% | 0.19 | 9 / 241 | 0% | 0 | 0 / 0 |
| esophagus | 0% | 0.01 | 6 / 1445 | 3% | 0.05 | 6 / 183 |
| uterus | 0% | 0 | 0 / 170 | 2% | 0.03 | 8 / 459 |
| prostate | 1% | 0.06 | 2 / 245 | 1% | 0.02 | 4 / 502 |
| pancreas | 0% | 0.01 | 1 / 328 | 1% | 0.03 | 2 / 178 |
| peripheral blood | 1% | 0.06 | 12 / 929 | 0% | 0 | 0 / 0 |
| bladder | 0% | 0 | 0 / 21 | 1% | 0.02 | 5 / 504 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.01 | 3 / 406 |
| kidney | 0% | 0 | 0 / 89 | 0% | 0.01 | 4 / 901 |
| adipose | 0% | 0.01 | 3 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 0% | 0 | 0 / 180 | 0% | 0.00 | 1 / 430 |
| muscle | 0% | 0.00 | 1 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0.00 | 1 / 1335 | 0% | 0 | 0 / 0 |
| brain | 0% | 0.00 | 1 / 2642 | 0% | 0 | 0 / 705 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adrenal gland | 0% | 0 | 0 / 258 | 0% | 0 | 0 / 230 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042531 | Biological process | positive regulation of tyrosine phosphorylation of STAT protein |
| GO_0042102 | Biological process | positive regulation of T cell proliferation |
| GO_0007260 | Biological process | tyrosine phosphorylation of STAT protein |
| GO_0002639 | Biological process | positive regulation of immunoglobulin production |
| GO_0045954 | Biological process | positive regulation of natural killer cell mediated cytotoxicity |
| GO_0007165 | Biological process | signal transduction |
| GO_0051607 | Biological process | defense response to virus |
| GO_0034105 | Biological process | positive regulation of tissue remodeling |
| GO_0002314 | Biological process | germinal center B cell differentiation |
| GO_0098586 | Biological process | cellular response to virus |
| GO_0061470 | Biological process | T follicular helper cell differentiation |
| GO_0030890 | Biological process | positive regulation of B cell proliferation |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0032729 | Biological process | positive regulation of type II interferon production |
| GO_0050729 | Biological process | positive regulation of inflammatory response |
| GO_0001819 | Biological process | positive regulation of cytokine production |
| GO_0048469 | Biological process | cell maturation |
| GO_0032740 | Biological process | positive regulation of interleukin-17 production |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005126 | Molecular function | cytokine receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005134 | Molecular function | interleukin-2 receptor binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | IL21 |
| Protein name | Interleukin Interleukin-21 (IL-21) (Za11) |
| Synonyms | IL-21 hCG_38188 |
| Description | FUNCTION: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells . During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity). . |
| Accessions | A0A224B028 Q9HBE4 ENST00000648588.1 [Q9HBE4-1] ENST00000611104.2 [Q9HBE4-2] |
