IRF8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002376Biological processimmune system process
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0042832Biological processdefense response to protozoan
GO_0032735Biological processpositive regulation of interleukin-12 production
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0097028Biological processdendritic cell differentiation
GO_0032479Biological processregulation of type I interferon production
GO_0071346Biological processcellular response to type II interferon
GO_0006955Biological processimmune response
GO_0002314Biological processgerminal center B cell differentiation
GO_0030099Biological processmyeloid cell differentiation
GO_0006909Biological processphagocytosis
GO_0042742Biological processdefense response to bacterium
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0032729Biological processpositive regulation of type II interferon production
GO_0006914Biological processautophagy
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0002316Biological processfollicular B cell differentiation
GO_0002273Biological processplasmacytoid dendritic cell differentiation
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIRF8
Protein nameInterferon regulatory factor 8
Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP)
SynonymsICSBP1
DescriptionFUNCTION: Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) . Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells . Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). .

AccessionsA0A8Q3SJ00
ENST00000562492.5
ENST00000566369.2
ENST00000563180.1
Q02556
H3BT31
H3BNX4
H3BQK3
ENST00000565552.1
A0A8Q3SJ42
ENST00000564803.6
H3BQF9
H3BRT4
ENST00000696887.1
ENST00000696884.1
ENST00000569145.5
ENST00000569607.2
ENST00000564803.5
ENST00000268638.10
H3BQH6
H3BVC2
ENST00000696885.1
ENST00000564617.5