Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 40 studies | 43% ± 13% | |
plasmacytoid dendritic cell | 30 studies | 84% ± 18% | |
conventional dendritic cell | 26 studies | 37% ± 19% | |
macrophage | 24 studies | 28% ± 10% | |
memory B cell | 20 studies | 47% ± 14% | |
naive B cell | 20 studies | 45% ± 12% | |
dendritic cell | 13 studies | 40% ± 21% | |
monocyte | 11 studies | 25% ± 9% | |
natural killer cell | 11 studies | 29% ± 11% | |
classical monocyte | 11 studies | 28% ± 14% | |
non-classical monocyte | 11 studies | 27% ± 10% | |
microglial cell | 11 studies | 31% ± 12% | |
myeloid cell | 9 studies | 33% ± 11% | |
alveolar macrophage | 6 studies | 20% ± 4% | |
CD16-negative, CD56-bright natural killer cell, human | 6 studies | 30% ± 9% | |
immature B cell | 6 studies | 47% ± 5% | |
mononuclear phagocyte | 5 studies | 39% ± 20% | |
CD16-positive, CD56-dim natural killer cell, human | 5 studies | 21% ± 5% | |
leukocyte | 4 studies | 31% ± 5% | |
precursor B cell | 4 studies | 35% ± 10% | |
germinal center B cell | 4 studies | 55% ± 17% | |
endothelial cell of lymphatic vessel | 3 studies | 20% ± 3% | |
hematopoietic precursor cell | 3 studies | 43% ± 23% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 4 studies | 31% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
stomach | 90% | 990.40 | 324 / 359 | 98% | 38.10 | 279 / 286 |
lung | 100% | 2422.39 | 576 / 578 | 88% | 18.18 | 1016 / 1155 |
breast | 95% | 1319.66 | 436 / 459 | 86% | 15.13 | 957 / 1118 |
intestine | 82% | 2572.28 | 789 / 966 | 97% | 37.46 | 510 / 527 |
liver | 97% | 1071.58 | 219 / 226 | 75% | 9.94 | 304 / 406 |
kidney | 76% | 759.09 | 68 / 89 | 81% | 16.25 | 732 / 901 |
prostate | 70% | 454.52 | 172 / 245 | 57% | 5.93 | 287 / 502 |
pancreas | 37% | 165.08 | 120 / 328 | 90% | 26.55 | 160 / 178 |
brain | 37% | 229.86 | 972 / 2642 | 89% | 15.50 | 625 / 705 |
bladder | 67% | 397.90 | 14 / 21 | 59% | 18.97 | 295 / 504 |
thymus | 68% | 567.65 | 441 / 653 | 57% | 10.87 | 343 / 605 |
esophagus | 45% | 223.76 | 645 / 1445 | 71% | 18.28 | 130 / 183 |
adrenal gland | 91% | 607.71 | 234 / 258 | 22% | 2.01 | 51 / 230 |
skin | 36% | 172.95 | 647 / 1809 | 67% | 15.58 | 316 / 472 |
lymph node | 0% | 0 | 0 / 0 | 100% | 306.40 | 29 / 29 |
spleen | 100% | 13152.79 | 241 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 5963.72 | 923 / 929 | 0% | 0 | 0 / 0 |
adipose | 99% | 2042.76 | 1192 / 1204 | 0% | 0 | 0 / 0 |
uterus | 30% | 150.85 | 51 / 170 | 61% | 7.22 | 278 / 459 |
tonsil | 0% | 0 | 0 / 0 | 84% | 19.06 | 38 / 45 |
ovary | 19% | 109.22 | 34 / 180 | 55% | 4.81 | 235 / 430 |
blood vessel | 46% | 402.49 | 619 / 1335 | 0% | 0 | 0 / 0 |
heart | 25% | 120.11 | 215 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 19% | 2.05 | 15 / 80 |
muscle | 0% | 1.80 | 4 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0002376 | Biological process | immune system process |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0042832 | Biological process | defense response to protozoan |
GO_0032735 | Biological process | positive regulation of interleukin-12 production |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0097028 | Biological process | dendritic cell differentiation |
GO_0032479 | Biological process | regulation of type I interferon production |
GO_0071346 | Biological process | cellular response to type II interferon |
GO_0006955 | Biological process | immune response |
GO_0002314 | Biological process | germinal center B cell differentiation |
GO_0030099 | Biological process | myeloid cell differentiation |
GO_0006909 | Biological process | phagocytosis |
GO_0042742 | Biological process | defense response to bacterium |
GO_0071222 | Biological process | cellular response to lipopolysaccharide |
GO_0032729 | Biological process | positive regulation of type II interferon production |
GO_0006914 | Biological process | autophagy |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0002316 | Biological process | follicular B cell differentiation |
GO_0002273 | Biological process | plasmacytoid dendritic cell differentiation |
GO_0005634 | Cellular component | nucleus |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | IRF8 |
Protein name | Interferon regulatory factor 8 Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP) |
Synonyms | ICSBP1 |
Description | FUNCTION: Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) . Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells . Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). . |
Accessions | A0A8Q3SJ00 ENST00000562492.5 ENST00000566369.2 ENST00000563180.1 Q02556 H3BT31 H3BNX4 H3BQK3 ENST00000565552.1 A0A8Q3SJ42 ENST00000564803.6 H3BQF9 H3BRT4 ENST00000696887.1 ENST00000696884.1 ENST00000569145.5 ENST00000569607.2 ENST00000564803.5 ENST00000268638.10 H3BQH6 H3BVC2 ENST00000696885.1 ENST00000564617.5 |