Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 35 studies | 29% ± 11% | |
plasma cell | 22 studies | 52% ± 18% | |
memory B cell | 19 studies | 36% ± 9% | |
naive B cell | 15 studies | 27% ± 8% | |
plasmablast | 10 studies | 61% ± 21% | |
ciliated cell | 10 studies | 25% ± 7% | |
IgG plasma cell | 9 studies | 34% ± 15% | |
IgA plasma cell | 8 studies | 37% ± 20% | |
precursor B cell | 6 studies | 44% ± 14% | |
pro-B cell | 5 studies | 41% ± 16% | |
immature B cell | 4 studies | 38% ± 10% | |
germinal center B cell | 4 studies | 49% ± 21% | |
IgM plasma cell | 3 studies | 41% ± 15% |
Insufficient scRNA-seq data for expression of POU2AF1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 90% | 603.68 | 520 / 578 | 86% | 14.27 | 999 / 1155 |
stomach | 77% | 1584.70 | 276 / 359 | 65% | 10.04 | 186 / 286 |
intestine | 60% | 2154.56 | 575 / 966 | 60% | 7.87 | 317 / 527 |
bladder | 52% | 344.19 | 11 / 21 | 53% | 5.73 | 266 / 504 |
prostate | 84% | 363.54 | 205 / 245 | 18% | 0.93 | 92 / 502 |
lymph node | 0% | 0 | 0 / 0 | 100% | 198.89 | 29 / 29 |
spleen | 100% | 12719.72 | 241 / 241 | 0% | 0 | 0 / 0 |
esophagus | 30% | 156.23 | 438 / 1445 | 69% | 8.89 | 127 / 183 |
peripheral blood | 97% | 11478.13 | 901 / 929 | 0% | 0 | 0 / 0 |
breast | 42% | 238.09 | 195 / 459 | 47% | 4.46 | 528 / 1118 |
tonsil | 0% | 0 | 0 / 0 | 84% | 21.36 | 38 / 45 |
uterus | 32% | 82.88 | 55 / 170 | 49% | 4.58 | 226 / 459 |
thymus | 39% | 480.04 | 254 / 653 | 42% | 4.66 | 254 / 605 |
pancreas | 6% | 11.27 | 20 / 328 | 58% | 7.33 | 104 / 178 |
kidney | 40% | 241.88 | 36 / 89 | 17% | 1.34 | 150 / 901 |
ovary | 25% | 48.12 | 45 / 180 | 31% | 1.67 | 134 / 430 |
liver | 33% | 72.88 | 75 / 226 | 15% | 1.36 | 62 / 406 |
skin | 3% | 5.33 | 46 / 1809 | 46% | 7.24 | 216 / 472 |
brain | 24% | 57.19 | 628 / 2642 | 2% | 0.52 | 14 / 705 |
adipose | 16% | 68.03 | 187 / 1204 | 0% | 0 | 0 / 0 |
adrenal gland | 7% | 24.22 | 19 / 258 | 3% | 0.20 | 7 / 230 |
blood vessel | 10% | 60.97 | 130 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 4% | 0.51 | 3 / 80 |
heart | 3% | 9.94 | 29 / 861 | 0% | 0 | 0 / 0 |
muscle | 0% | 0.60 | 4 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0002314 | Biological process | germinal center B cell differentiation |
GO_0098586 | Biological process | cellular response to virus |
GO_0032755 | Biological process | positive regulation of interleukin-6 production |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0006959 | Biological process | humoral immune response |
GO_0090575 | Cellular component | RNA polymerase II transcription regulator complex |
GO_0003677 | Molecular function | DNA binding |
GO_0003713 | Molecular function | transcription coactivator activity |
GO_0005515 | Molecular function | protein binding |
GO_0070974 | Molecular function | POU domain binding |
GO_0003712 | Molecular function | transcription coregulator activity |
Gene name | POU2AF1 |
Protein name | POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1) POU class 2 homeobox associating factor 1 |
Synonyms | OBF1 BOB1 |
Description | FUNCTION: Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 . It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 . It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2 . It is essential for the response of B-cells to antigens and required for the formation of germinal centers . Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity). . |
Accessions | ENST00000531398.1 Q16633 E9PKH4 ENST00000393067.8 |