POU2AF1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POU2AF1 at tissue level.

III. Associated gene sets

GO_0002314Biological processgerminal center B cell differentiation
GO_0098586Biological processcellular response to virus
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006959Biological processhumoral immune response
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0003677Molecular functionDNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0070974Molecular functionPOU domain binding
GO_0003712Molecular functiontranscription coregulator activity

IV. Literature review

[source]
Gene namePOU2AF1
Protein namePOU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)
POU class 2 homeobox associating factor 1
SynonymsOBF1
BOB1
DescriptionFUNCTION: Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 . It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 . It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2 . It is essential for the response of B-cells to antigens and required for the formation of germinal centers . Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity). .

AccessionsENST00000531398.1
Q16633
E9PKH4
ENST00000393067.8