Name | Number of supported studies | Average coverage | |
---|---|---|---|
epithelial cell | 6 studies | 25% ± 7% | |
macrophage | 5 studies | 21% ± 4% | |
oligodendrocyte | 5 studies | 25% ± 6% | |
ciliated cell | 4 studies | 16% ± 1% | |
GABAergic neuron | 4 studies | 27% ± 10% | |
glutamatergic neuron | 4 studies | 32% ± 10% | |
adipocyte | 4 studies | 22% ± 3% | |
endothelial cell | 3 studies | 24% ± 4% | |
B cell | 3 studies | 16% ± 1% | |
goblet cell | 3 studies | 23% ± 9% | |
neuron | 3 studies | 25% ± 8% | |
plasmacytoid dendritic cell | 3 studies | 21% ± 2% | |
astrocyte | 3 studies | 27% ± 8% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 5 studies | 28% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 2442.49 | 180 / 180 | 100% | 19.87 | 430 / 430 |
stomach | 100% | 1408.53 | 359 / 359 | 100% | 11.63 | 286 / 286 |
thymus | 100% | 2881.76 | 653 / 653 | 100% | 23.66 | 604 / 605 |
prostate | 100% | 1838.75 | 245 / 245 | 100% | 11.06 | 500 / 502 |
breast | 100% | 1712.49 | 459 / 459 | 100% | 12.42 | 1113 / 1118 |
esophagus | 100% | 1327.03 | 1445 / 1445 | 99% | 9.47 | 182 / 183 |
pancreas | 100% | 1417.10 | 328 / 328 | 99% | 11.05 | 177 / 178 |
intestine | 100% | 1666.35 | 966 / 966 | 99% | 13.05 | 524 / 527 |
bladder | 100% | 1687.10 | 21 / 21 | 99% | 11.97 | 501 / 504 |
kidney | 100% | 1565.88 | 89 / 89 | 99% | 13.50 | 894 / 901 |
lung | 100% | 1421.06 | 577 / 578 | 99% | 11.12 | 1148 / 1155 |
skin | 100% | 1363.92 | 1809 / 1809 | 99% | 12.52 | 468 / 472 |
uterus | 100% | 2239.46 | 170 / 170 | 99% | 11.29 | 455 / 459 |
adrenal gland | 100% | 1691.40 | 258 / 258 | 99% | 13.36 | 227 / 230 |
brain | 98% | 992.22 | 2588 / 2642 | 100% | 10.03 | 703 / 705 |
liver | 100% | 851.99 | 226 / 226 | 78% | 5.32 | 316 / 406 |
adipose | 100% | 1461.59 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1528.87 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 10.68 | 29 / 29 |
spleen | 100% | 2308.75 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 9.17 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.52 | 1 / 1 |
heart | 98% | 795.90 | 842 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 17.03 | 78 / 80 |
muscle | 95% | 530.57 | 759 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 90% | 777.65 | 839 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0002314 | Biological process | germinal center B cell differentiation |
GO_0042149 | Biological process | cellular response to glucose starvation |
GO_0032006 | Biological process | regulation of TOR signaling |
GO_1904262 | Biological process | negative regulation of TORC1 signaling |
GO_0034198 | Biological process | cellular response to amino acid starvation |
GO_0140007 | Cellular component | KICSTOR complex |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005765 | Cellular component | lysosomal membrane |
Gene name | ITFG2 |
Protein name | Integrin alpha FG-GAP repeat containing 2 isoform 1 KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2) Integrin alpha FG-GAP repeat containing 2 isoform 2 Integrin alpha FG-GAP repeat containing 2 isoform 3 Integrin alpha FG-GAP repeat containing 2 |
Synonyms | |
Description | FUNCTION: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. . |
Accessions | ENST00000228799.7 [Q969R8-1] ENST00000538822.1 ENST00000540929.5 [Q969R8-2] ENST00000540662.1 A0A2R8Y7E0 H0YGR0 A0A0S2Z5L6 F5H1D0 ENST00000644123.1 H0YFM4 Q969R8 ENST00000537851.5 H0YG72 A0A0S2Z5G6 A0A0S2Z5P1 ENST00000534935.5 ENST00000644517.1 [Q969R8-2] |