ITFG2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002314Biological processgerminal center B cell differentiation
GO_0042149Biological processcellular response to glucose starvation
GO_0032006Biological processregulation of TOR signaling
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0034198Biological processcellular response to amino acid starvation
GO_0140007Cellular componentKICSTOR complex
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0005765Cellular componentlysosomal membrane

IV. Literature review

[source]
Gene nameITFG2
Protein nameIntegrin alpha FG-GAP repeat containing 2 isoform 1
KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2)
Integrin alpha FG-GAP repeat containing 2 isoform 2
Integrin alpha FG-GAP repeat containing 2 isoform 3
Integrin alpha FG-GAP repeat containing 2
Synonyms
DescriptionFUNCTION: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. .

AccessionsENST00000228799.7 [Q969R8-1]
ENST00000538822.1
ENST00000540929.5 [Q969R8-2]
ENST00000540662.1
A0A2R8Y7E0
H0YGR0
A0A0S2Z5L6
F5H1D0
ENST00000644123.1
H0YFM4
Q969R8
ENST00000537851.5
H0YG72
A0A0S2Z5G6
A0A0S2Z5P1
ENST00000534935.5
ENST00000644517.1 [Q969R8-2]