ADAM17 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007220Biological processNotch receptor processing
GO_0048870Biological processcell motility
GO_0032722Biological processpositive regulation of chemokine production
GO_1903265Biological processpositive regulation of tumor necrosis factor-mediated signaling pathway
GO_0033627Biological processcell adhesion mediated by integrin
GO_0007219Biological processNotch signaling pathway
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0045741Biological processpositive regulation of epidermal growth factor-activated receptor activity
GO_0030307Biological processpositive regulation of cell growth
GO_0043536Biological processpositive regulation of blood vessel endothelial cell migration
GO_0002467Biological processgerminal center formation
GO_0071403Biological processcellular response to high density lipoprotein particle stimulus
GO_0010820Biological processpositive regulation of T cell chemotaxis
GO_0016485Biological processprotein processing
GO_0045737Biological processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
GO_1905564Biological processpositive regulation of vascular endothelial cell proliferation
GO_0007155Biological processcell adhesion
GO_0023061Biological processsignal release
GO_0048536Biological processspleen development
GO_1900087Biological processpositive regulation of G1/S transition of mitotic cell cycle
GO_0033077Biological processT cell differentiation in thymus
GO_0071679Biological processcommissural neuron axon guidance
GO_0002446Biological processneutrophil mediated immunity
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0030335Biological processpositive regulation of cell migration
GO_0033025Biological processregulation of mast cell apoptotic process
GO_0001666Biological processresponse to hypoxia
GO_0006508Biological processproteolysis
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0035313Biological processwound healing, spreading of epidermal cells
GO_0042987Biological processamyloid precursor protein catabolic process
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0002690Biological processpositive regulation of leukocyte chemotaxis
GO_0030183Biological processB cell differentiation
GO_0032496Biological processresponse to lipopolysaccharide
GO_0006509Biological processmembrane protein ectodomain proteolysis
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0032587Cellular componentruffle membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0005925Cellular componentfocal adhesion
GO_0005911Cellular componentcell-cell junction
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0015629Cellular componentactin cytoskeleton
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0008233Molecular functionpeptidase activity
GO_0004175Molecular functionendopeptidase activity
GO_1902945Molecular functionmetalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO_0043120Molecular functiontumor necrosis factor binding
GO_0008237Molecular functionmetallopeptidase activity
GO_0005112Molecular functionNotch binding
GO_0019955Molecular functioncytokine binding
GO_0005178Molecular functionintegrin binding
GO_0030165Molecular functionPDZ domain binding
GO_0005138Molecular functioninterleukin-6 receptor binding
GO_0046872Molecular functionmetal ion binding
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameADAM17
Protein nameADAM metallopeptidase domain 17
ADAM metallopeptidase domain 17 (ADAM metallopeptidase domain 18)
ADAM metallopeptidase domain 17 (ADAM17 protein)
ADAM17 protein
Uncharacterized protein ADAM17
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)
SynonymshCG_23065
ADAM18
CSVP
TACE
DescriptionFUNCTION: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form . Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface . Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein . Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) . Plays a role in the proteolytic processing of ACE2 . Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R . Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. .

AccessionsENST00000699318.1
ENST00000699324.1
ENST00000648002.1
A0A3B3ITB5
ENST00000650116.1
A0A8V8TN27
A0A8V8TPV7
A0A8V8TNK7
ENST00000649227.1
A8K1B4
ENST00000310823.8 [P78536-1]
ENST00000699321.1
ENST00000699317.1
ENST00000647610.1
A0A3B3IST4
ENST00000699316.1
ENST00000647979.1
ENST00000618923.2
A0A3B3ISQ1
Q53S40
A6H8L4
A0A8V8TPG8
P78536
A0A3B3ITW9
Q6P5T8
Q53RF5
ENST00000647622.1
ENST00000699325.1
Q53RS1
A0A8V8TNK2
B2RNB2