SOD2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	36 studies	53% ± 22%	Explore
fibroblast	35 studies	51% ± 25%	Explore
endothelial cell	32 studies	43% ± 21%	Explore
monocyte	24 studies	56% ± 25%	Explore
classical monocyte	24 studies	62% ± 21%	Explore
dendritic cell	21 studies	46% ± 22%	Explore
conventional dendritic cell	21 studies	40% ± 17%	Explore
non-classical monocyte	21 studies	67% ± 18%	Explore
pericyte	20 studies	41% ± 26%	Explore
epithelial cell	18 studies	46% ± 24%	Explore
basal cell	17 studies	34% ± 16%	Explore
smooth muscle cell	16 studies	34% ± 17%	Explore
B cell	14 studies	27% ± 12%	Explore
neutrophil	14 studies	71% ± 24%	Explore
CD4-positive, alpha-beta T cell	14 studies	23% ± 4%	Explore
regulatory T cell	14 studies	21% ± 5%	Explore
myeloid cell	14 studies	45% ± 25%	Explore
T cell	13 studies	26% ± 10%	Explore
endothelial cell of lymphatic vessel	12 studies	37% ± 23%	Explore
astrocyte	12 studies	39% ± 14%	Explore
connective tissue cell	11 studies	35% ± 20%	Explore
type II pneumocyte	10 studies	45% ± 19%	Explore
ciliated cell	10 studies	33% ± 21%	Explore
natural killer cell	9 studies	25% ± 7%	Explore
platelet	9 studies	45% ± 13%	Explore
endothelial cell of vascular tree	9 studies	57% ± 30%	Explore
vein endothelial cell	9 studies	38% ± 13%	Explore
mast cell	8 studies	23% ± 12%	Explore
mononuclear phagocyte	8 studies	55% ± 22%	Explore
alveolar macrophage	7 studies	36% ± 8%	Explore
plasma cell	7 studies	25% ± 12%	Explore
club cell	7 studies	29% ± 13%	Explore
secretory cell	7 studies	47% ± 22%	Explore
plasmacytoid dendritic cell	7 studies	25% ± 13%	Explore
naive B cell	7 studies	24% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	22% ± 9%	Explore
memory B cell	7 studies	21% ± 4%	Explore
mesothelial cell	7 studies	40% ± 17%	Explore
leukocyte	6 studies	35% ± 18%	Explore
glutamatergic neuron	6 studies	42% ± 20%	Explore
abnormal cell	6 studies	36% ± 21%	Explore
CD8-positive, alpha-beta T cell	6 studies	18% ± 2%	Explore
microglial cell	6 studies	31% ± 11%	Explore
endothelial cell of artery	6 studies	22% ± 6%	Explore
intermediate monocyte	6 studies	62% ± 17%	Explore
hepatocyte	6 studies	35% ± 18%	Explore
ionocyte	5 studies	31% ± 5%	Explore
respiratory goblet cell	5 studies	22% ± 2%	Explore
monocyte-derived dendritic cell	5 studies	63% ± 21%	Explore
kidney loop of Henle epithelial cell	5 studies	29% ± 8%	Explore
neuron	5 studies	35% ± 10%	Explore
GABAergic neuron	5 studies	37% ± 19%	Explore
precursor B cell	5 studies	32% ± 12%	Explore
retinal pigment epithelial cell	5 studies	45% ± 11%	Explore
adventitial cell	5 studies	51% ± 7%	Explore
capillary endothelial cell	5 studies	27% ± 4%	Explore
myofibroblast cell	5 studies	26% ± 5%	Explore
inflammatory macrophage	5 studies	52% ± 25%	Explore
goblet cell	5 studies	31% ± 14%	Explore
keratinocyte	5 studies	42% ± 16%	Explore
oligodendrocyte	5 studies	34% ± 9%	Explore
type I pneumocyte	4 studies	35% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	23% ± 9%	Explore
epithelial cell of proximal tubule	4 studies	33% ± 12%	Explore
hematopoietic stem cell	4 studies	38% ± 4%	Explore
mucosal invariant T cell	4 studies	20% ± 2%	Explore
pro-B cell	4 studies	36% ± 3%	Explore
muscle cell	4 studies	38% ± 13%	Explore
erythrocyte	4 studies	24% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	20% ± 2%	Explore
T follicular helper cell	4 studies	25% ± 4%	Explore
Schwann cell	4 studies	47% ± 24%	Explore
interneuron	4 studies	41% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	27% ± 6%	Explore
duct epithelial cell	3 studies	43% ± 12%	Explore
hillock cell	3 studies	28% ± 10%	Explore
squamous epithelial cell	3 studies	52% ± 21%	Explore
pancreatic A cell	3 studies	31% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	36% ± 14%	Explore
retinal ganglion cell	3 studies	56% ± 23%	Explore
megakaryocyte	3 studies	60% ± 15%	Explore
retina horizontal cell	3 studies	19% ± 2%	Explore
retinal bipolar neuron	3 studies	19% ± 2%	Explore
serous secreting cell	3 studies	29% ± 7%	Explore
tissue-resident macrophage	3 studies	62% ± 24%	Explore
granulocyte	3 studies	24% ± 8%	Explore
luminal cell of prostate epithelium	3 studies	66% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	17% ± 2%	Explore
gamma-delta T cell	3 studies	28% ± 10%	Explore
plasmablast	3 studies	30% ± 15%	Explore
progenitor cell	3 studies	28% ± 9%	Explore
melanocyte	3 studies	28% ± 7%	Explore
transit amplifying cell	3 studies	32% ± 17%	Explore
adipocyte	3 studies	26% ± 7%	Explore
oligodendrocyte precursor cell	3 studies	34% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	34% ± 17%	Explore
peripheral blood	13 studies	30% ± 13%	Explore
brain	11 studies	31% ± 14%	Explore
intestine	7 studies	26% ± 12%	Explore
liver	7 studies	29% ± 10%	Explore
kidney	6 studies	29% ± 14%	Explore
eye	5 studies	35% ± 17%	Explore
skin	5 studies	42% ± 20%	Explore
pancreas	4 studies	35% ± 10%	Explore
uterus	4 studies	52% ± 15%	Explore
adipose	4 studies	24% ± 6%	Explore
esophagus	4 studies	31% ± 7%	Explore
prostate	4 studies	53% ± 18%	Explore
lymph node	4 studies	28% ± 15%	Explore
bone marrow	3 studies	20% ± 5%	Explore
adrenal gland	3 studies	22% ± 2%	Explore
thymus	3 studies	24% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	99%	70648.92	88 / 89	99%	251.05	893 / 901
lung	99%	61277.23	575 / 578	98%	87.80	1137 / 1155
liver	99%	79587.54	223 / 226	98%	124.75	397 / 406
intestine	95%	30069.80	922 / 966	96%	65.72	507 / 527
breast	98%	46166.32	451 / 459	91%	61.03	1019 / 1118
esophagus	92%	29953.63	1324 / 1445	97%	84.82	178 / 183
prostate	87%	40651.16	212 / 245	97%	77.30	488 / 502
uterus	88%	23191.67	149 / 170	95%	81.12	434 / 459
bladder	95%	43551.86	20 / 21	82%	58.36	415 / 504
adrenal gland	96%	53498.15	247 / 258	75%	31.90	172 / 230
pancreas	66%	26679.32	216 / 328	96%	74.29	170 / 178
brain	67%	13278.52	1782 / 2642	93%	133.42	656 / 705
skin	80%	29013.53	1451 / 1809	78%	42.81	366 / 472
stomach	60%	23135.60	216 / 359	97%	67.19	277 / 286
thymus	77%	19481.30	505 / 653	79%	31.25	475 / 605
ovary	72%	13229.12	130 / 180	66%	31.96	283 / 430
muscle	100%	436661.67	803 / 803	0%	0	0 / 0
adipose	100%	61556.25	1200 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	107.66	44 / 45
blood vessel	91%	25013.52	1212 / 1335	0%	0	0 / 0
heart	91%	29765.59	780 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	149.05	26 / 29
spleen	79%	12707.74	191 / 241	0%	0	0 / 0
peripheral blood	79%	45725.81	731 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	49%	18.53	39 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0042542	Biological process	response to hydrogen peroxide
GO_1905461	Biological process	positive regulation of vascular associated smooth muscle cell apoptotic process
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0003069	Biological process	acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
GO_1902631	Biological process	negative regulation of membrane hyperpolarization
GO_0010042	Biological process	response to manganese ion
GO_0030097	Biological process	hemopoiesis
GO_0048147	Biological process	negative regulation of fibroblast proliferation
GO_0009791	Biological process	post-embryonic development
GO_0048773	Biological process	erythrophore differentiation
GO_1904706	Biological process	negative regulation of vascular associated smooth muscle cell proliferation
GO_0007507	Biological process	heart development
GO_0071361	Biological process	cellular response to ethanol
GO_0051602	Biological process	response to electrical stimulus
GO_0003032	Biological process	detection of oxygen
GO_0000303	Biological process	response to superoxide
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0010332	Biological process	response to gamma radiation
GO_0010729	Biological process	positive regulation of hydrogen peroxide biosynthetic process
GO_0008217	Biological process	regulation of blood pressure
GO_0048678	Biological process	response to axon injury
GO_0042554	Biological process	superoxide anion generation
GO_0035902	Biological process	response to immobilization stress
GO_0035900	Biological process	response to isolation stress
GO_0045599	Biological process	negative regulation of fat cell differentiation
GO_1902176	Biological process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_0001889	Biological process	liver development
GO_0060586	Biological process	multicellular organismal-level iron ion homeostasis
GO_0014823	Biological process	response to activity
GO_0051881	Biological process	regulation of mitochondrial membrane potential
GO_0046686	Biological process	response to cadmium ion
GO_0071000	Biological process	response to magnetism
GO_0055093	Biological process	response to hyperoxia
GO_0034599	Biological process	cellular response to oxidative stress
GO_0030335	Biological process	positive regulation of cell migration
GO_0001666	Biological process	response to hypoxia
GO_0048666	Biological process	neuron development
GO_0022904	Biological process	respiratory electron transport chain
GO_0008630	Biological process	intrinsic apoptotic signaling pathway in response to DNA damage
GO_0010043	Biological process	response to zinc ion
GO_0001836	Biological process	release of cytochrome c from mitochondria
GO_0050665	Biological process	hydrogen peroxide biosynthetic process
GO_0033591	Biological process	response to L-ascorbic acid
GO_0045429	Biological process	positive regulation of nitric oxide biosynthetic process
GO_1905932	Biological process	positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
GO_0032364	Biological process	intracellular oxygen homeostasis
GO_0006801	Biological process	superoxide metabolic process
GO_0019430	Biological process	removal of superoxide radicals
GO_0008631	Biological process	intrinsic apoptotic signaling pathway in response to oxidative stress
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0010269	Biological process	response to selenium ion
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0034021	Biological process	response to silicon dioxide
GO_0007626	Biological process	locomotory behavior
GO_0006749	Biological process	glutathione metabolic process
GO_0032496	Biological process	response to lipopolysaccharide
GO_0051289	Biological process	protein homotetramerization
GO_0042645	Cellular component	mitochondrial nucleoid
GO_0005739	Cellular component	mitochondrion
GO_0070062	Cellular component	extracellular exosome
GO_0005759	Cellular component	mitochondrial matrix
GO_0003677	Molecular function	DNA binding
GO_0019899	Molecular function	enzyme binding
GO_0004784	Molecular function	superoxide dismutase activity
GO_0042802	Molecular function	identical protein binding
GO_0030145	Molecular function	manganese ion binding
GO_0019825	Molecular function	oxygen binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SOD2
Protein name	Superoxide dismutase (EC 1.15.1.1) Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) Manganese superoxide dismutase (EC 1.15.1.1)
Synonyms	hCG_34035
Description	FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. . FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. .; FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. . FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. .; FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. . FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. .; FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. . FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. .; FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. . FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. .; FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. . FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. .; FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. . FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. . FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. .; FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. . FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. . FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. .; FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. . FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. .; FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. . FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. .
Accessions	ENST00000367054.6 [P04179-2] Q7Z7M5 Q7Z7M4 Q71UR9 ENST00000546087.5 [P04179-4] Q7Z7M6 G5E9P6 ENST00000546260.5 F5GYZ5 P04179 ENST00000444946.6 [P04179-3] ENST00000545162.5 F5H4R2 Q7Z7M7 ENST00000538183.7 [P04179-1] Q6LE88 Q4ZJI1 ENST00000337404.8 [P04179-2] F5H3C5 ENST00000452684.2 G8JLJ2 ENST00000401980.3 ENST00000535561.5 ENST00000367055.8 [P04179-1] F5GXZ9 ENST00000537657.5

SOD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review