Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| goblet cell | 9 studies | 34% ± 16% | |
| fibroblast | 7 studies | 21% ± 4% | |
| epithelial cell | 5 studies | 28% ± 12% | |
| ciliated cell | 3 studies | 37% ± 7% | |
| type I pneumocyte | 3 studies | 23% ± 10% | |
| enteroendocrine cell | 3 studies | 20% ± 3% |
Insufficient scRNA-seq data for expression of ANG at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 14961.29 | 226 / 226 | 100% | 345.97 | 405 / 406 |
| intestine | 99% | 500.73 | 961 / 966 | 97% | 26.11 | 513 / 527 |
| prostate | 100% | 658.94 | 245 / 245 | 97% | 28.83 | 485 / 502 |
| stomach | 100% | 699.58 | 359 / 359 | 96% | 19.66 | 274 / 286 |
| pancreas | 100% | 305.38 | 327 / 328 | 96% | 25.78 | 171 / 178 |
| breast | 100% | 734.08 | 459 / 459 | 90% | 14.65 | 1008 / 1118 |
| kidney | 98% | 307.08 | 87 / 89 | 86% | 20.18 | 778 / 901 |
| lung | 99% | 372.37 | 573 / 578 | 72% | 9.72 | 832 / 1155 |
| uterus | 100% | 634.36 | 170 / 170 | 63% | 8.65 | 289 / 459 |
| bladder | 100% | 485.52 | 21 / 21 | 63% | 10.31 | 317 / 504 |
| skin | 97% | 410.26 | 1755 / 1809 | 59% | 4.68 | 277 / 472 |
| esophagus | 95% | 326.16 | 1377 / 1445 | 60% | 9.28 | 109 / 183 |
| thymus | 95% | 184.40 | 620 / 653 | 59% | 4.30 | 359 / 605 |
| ovary | 100% | 1029.18 | 180 / 180 | 36% | 2.55 | 154 / 430 |
| adipose | 100% | 698.08 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 29.27 | 1 / 1 |
| blood vessel | 100% | 576.74 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 80% | 140.22 | 194 / 241 | 0% | 0 | 0 / 0 |
| heart | 73% | 146.49 | 628 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 49% | 98.44 | 455 / 929 | 0% | 0 | 0 / 0 |
| brain | 6% | 7.74 | 158 / 2642 | 28% | 2.19 | 195 / 705 |
| tonsil | 0% | 0 | 0 / 0 | 33% | 2.57 | 15 / 45 |
| adrenal gland | 16% | 18.06 | 41 / 258 | 13% | 1.20 | 31 / 230 |
| muscle | 27% | 35.85 | 217 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 23% | 1.44 | 18 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.29 | 2 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0042327 | Biological process | positive regulation of phosphorylation |
| GO_0001525 | Biological process | angiogenesis |
| GO_0032148 | Biological process | activation of protein kinase B activity |
| GO_0045087 | Biological process | innate immune response |
| GO_0001541 | Biological process | ovarian follicle development |
| GO_0019731 | Biological process | antibacterial humoral response |
| GO_0016078 | Biological process | tRNA decay |
| GO_0030041 | Biological process | actin filament polymerization |
| GO_0001890 | Biological process | placenta development |
| GO_0001556 | Biological process | oocyte maturation |
| GO_0050714 | Biological process | positive regulation of protein secretion |
| GO_0009725 | Biological process | response to hormone |
| GO_0050830 | Biological process | defense response to Gram-positive bacterium |
| GO_0001938 | Biological process | positive regulation of endothelial cell proliferation |
| GO_0032431 | Biological process | activation of phospholipase A2 activity |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0048662 | Biological process | negative regulation of smooth muscle cell proliferation |
| GO_0006651 | Biological process | diacylglycerol biosynthetic process |
| GO_0007154 | Biological process | cell communication |
| GO_0042592 | Biological process | homeostatic process |
| GO_0061844 | Biological process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| GO_0009303 | Biological process | rRNA transcription |
| GO_0016477 | Biological process | cell migration |
| GO_0017148 | Biological process | negative regulation of translation |
| GO_0032311 | Cellular component | angiogenin-PRI complex |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0015629 | Cellular component | actin cytoskeleton |
| GO_0005829 | Cellular component | cytosol |
| GO_0030426 | Cellular component | growth cone |
| GO_0005604 | Cellular component | basement membrane |
| GO_0005694 | Cellular component | chromosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0008201 | Molecular function | heparin binding |
| GO_0004521 | Molecular function | RNA endonuclease activity |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0004540 | Molecular function | RNA nuclease activity |
| GO_0019843 | Molecular function | rRNA binding |
| GO_0004519 | Molecular function | endonuclease activity |
| GO_0042277 | Molecular function | peptide binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0003779 | Molecular function | actin binding |
| GO_0005507 | Molecular function | copper ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ANG |
| Protein name | Angiogenin (EC 3.1.27.-) (Ribonuclease 5) (RNase 5) |
| Synonyms | RNASE5 |
| Description | FUNCTION: Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) . Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus . Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA . Angiogenin induces vascularization of normal and malignant tissues . Angiogenic activity is regulated by interaction with RNH1 in vivo . . |
| Accessions | P03950 ENST00000397990.5 ENST00000336811.10 |
