EP300 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010742Biological processmacrophage derived foam cell differentiation
GO_0030324Biological processlung development
GO_0010821Biological processregulation of mitochondrion organization
GO_0010976Biological processpositive regulation of neuron projection development
GO_0090043Biological processregulation of tubulin deacetylation
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_0140067Biological processpeptidyl-lysine butyrylation
GO_0018393Biological processinternal peptidyl-lysine acetylation
GO_0035264Biological processmulticellular organism growth
GO_0031669Biological processcellular response to nutrient levels
GO_0050821Biological processprotein stabilization
GO_0001666Biological processresponse to hypoxia
GO_0030183Biological processB cell differentiation
GO_0140066Biological processpeptidyl-lysine crotonylation
GO_0007519Biological processskeletal muscle tissue development
GO_0034644Biological processcellular response to UV
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0006110Biological processregulation of glycolytic process
GO_0036268Biological processswimming
GO_1900034Biological processregulation of cellular response to heat
GO_0010506Biological processregulation of autophagy
GO_0043923Biological processpositive regulation by host of viral transcription
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0060765Biological processregulation of androgen receptor signaling pathway
GO_0030220Biological processplatelet formation
GO_0007399Biological processnervous system development
GO_0001966Biological processthigmotaxis
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0009887Biological processanimal organ morphogenesis
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0031648Biological processprotein destabilization
GO_0002223Biological processstimulatory C-type lectin receptor signaling pathway
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0001756Biological processsomitogenesis
GO_0018076Biological processN-terminal peptidyl-lysine acetylation
GO_2000330Biological processpositive regulation of T-helper 17 cell lineage commitment
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0006473Biological processprotein acetylation
GO_0060325Biological processface morphogenesis
GO_0046427Biological processpositive regulation of receptor signaling pathway via JAK-STAT
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071233Biological processcellular response to L-leucine
GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_0043627Biological processresponse to estrogen
GO_0045721Biological processnegative regulation of gluconeogenesis
GO_0007507Biological processheart development
GO_0007611Biological processlearning or memory
GO_0006475Biological processinternal protein amino acid acetylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0018394Biological processpeptidyl-lysine acetylation
GO_0007623Biological processcircadian rhythm
GO_0035855Biological processmegakaryocyte development
GO_0061921Biological processpeptidyl-lysine propionylation
GO_0002209Biological processbehavioral defense response
GO_0010507Biological processnegative regulation of autophagy
GO_0006915Biological processapoptotic process
GO_0032993Cellular componentprotein-DNA complex
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005829Cellular componentcytosol
GO_0000123Cellular componenthistone acetyltransferase complex
GO_0106226Molecular functionpeptide 2-hydroxyisobutyryltransferase activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0004468Molecular functionlysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO_0016407Molecular functionacetyltransferase activity
GO_0001223Molecular functiontranscription coactivator binding
GO_0140908Molecular functionhistone H3K122 acetyltransferase activity
GO_0010485Molecular functionhistone H4 acetyltransferase activity
GO_0008270Molecular functionzinc ion binding
GO_0120301Molecular functionhistone lactyltransferase (CoA-dependent) activity
GO_0048156Molecular functiontau protein binding
GO_0031490Molecular functionchromatin DNA binding
GO_0061920Molecular functionprotein propionyltransferase activity
GO_0004402Molecular functionhistone acetyltransferase activity
GO_0003682Molecular functionchromatin binding
GO_0010484Molecular functionhistone H3 acetyltransferase activity
GO_0140065Molecular functionpeptide butyryltransferase activity
GO_0140068Molecular functionhistone crotonyltransferase activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0140033Molecular functionacetylation-dependent protein binding
GO_0044017Molecular functionhistone H3K27 acetyltransferase activity
GO_0140069Molecular functionhistone butyryltransferase activity
GO_0097157Molecular functionpre-mRNA intronic binding
GO_0001221Molecular functiontranscription coregulator binding
GO_0002039Molecular functionp53 binding
GO_0034212Molecular functionpeptide N-acetyltransferase activity
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0043993Molecular functionhistone H3K18 acetyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0003677Molecular functionDNA binding
GO_0016922Molecular functionnuclear receptor binding
GO_0061733Molecular functionpeptide-lysine-N-acetyltransferase activity
GO_0097677Molecular functionSTAT family protein binding
GO_0016746Molecular functionacyltransferase activity
GO_0008013Molecular functionbeta-catenin binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0044013Molecular functionhistone H2B acetyltransferase activity
GO_0003684Molecular functiondamaged DNA binding
GO_0051059Molecular functionNF-kappaB binding

IV. Literature review

[source]
Gene nameEP300
Protein namehistone acetyltransferase (EC 2.3.1.48)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
SynonymsP300
DescriptionFUNCTION: Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling . Acetylates all four core histones in nucleosomes . Histone acetylation gives an epigenetic tag for transcriptional activation . Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability . Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) . Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation . Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) . Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2 or STAT3 . Acetylates 'Lys-131' of ALX1 and acts as its coactivator . Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function . Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis . Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription . Acetylates HDAC1 leading to its inactivation and modulation of transcription . Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 . Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement . Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity . Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin . Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity . Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter . Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity . Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity . Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) . Acetylates MEF2D . Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation . Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity . Acetylates RXRA and RXRG . Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase . Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex . Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP . In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively . Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors . Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low . Also acts as a histone butyryltransferase; butyrylation marks active promoters . Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription . Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes . Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway . .; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. .

AccessionsA0A994J3N7
ENST00000634690.1
ENST00000703544.1
Q7Z6C1
ENST00000703545.1
ENST00000263253.9
A0A669KB12
A0A0U1RR87
A0A994J6T4
ENST00000674155.1
Q09472