ARNT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046886Biological processpositive regulation of hormone biosynthetic process
GO_0001892Biological processembryonic placenta development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0030522Biological processintracellular receptor signaling pathway
GO_0033235Biological processpositive regulation of protein sumoylation
GO_0034599Biological processcellular response to oxidative stress
GO_0050728Biological processnegative regulation of inflammatory response
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0030154Biological processcell differentiation
GO_0001666Biological processresponse to hypoxia
GO_0010575Biological processpositive regulation of vascular endothelial growth factor production
GO_0045648Biological processpositive regulation of erythrocyte differentiation
GO_0030949Biological processpositive regulation of vascular endothelial growth factor receptor signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0016604Cellular componentnuclear body
GO_0034753Cellular componentnuclear aryl hydrocarbon receptor complex
GO_0005737Cellular componentcytoplasm
GO_0034751Cellular componentaryl hydrocarbon receptor complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0017162Molecular functionaryl hydrocarbon receptor binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0004879Molecular functionnuclear receptor activity
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARNT
Protein nameAryl hydrocarbon receptor nuclear translocator
Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)
SynonymsBHLHE2
DescriptionFUNCTION: Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding . The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription . .

AccessionsENST00000504358.1
P27540
F8T0U4
Q9UH46
ENST00000471844.6
I6L9E7
ENST00000505755.5 [P27540-2]
O43392
F8T0U3
D6RDB3
A6NGV6
ENST00000515192.5 [P27540-3]
ENST00000358595.10 [P27540-1]
ENST00000354396.6 [P27540-4]