Molecular function

GO:0003708, GO:0004880, GO:0004882, GO:0004884, GO:0004886, GO:0004887, GO:0008434, GO:0038050, GO:0038051, GO:0038052

RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity

A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.

ligand-dependent nuclear receptor activity, ligand-dependent transcription factor activity

Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'GO:0030374 ; nuclear receptor transcription coactivator activity' or GO:0140536 ; nuclear corepressor activity.