RORA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008589Biological processregulation of smoothened signaling pathway
GO_0070328Biological processtriglyceride homeostasis
GO_0001525Biological processangiogenesis
GO_0006805Biological processxenobiotic metabolic process
GO_0021702Biological processcerebellar Purkinje cell differentiation
GO_0019218Biological processregulation of steroid metabolic process
GO_0072539Biological processT-helper 17 cell differentiation
GO_0036315Biological processcellular response to sterol
GO_0042692Biological processmuscle cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0071456Biological processcellular response to hypoxia
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0030522Biological processintracellular receptor signaling pathway
GO_0043030Biological processregulation of macrophage activation
GO_0010906Biological processregulation of glucose metabolic process
GO_0046068Biological processcGMP metabolic process
GO_0071347Biological processcellular response to interleukin-1
GO_0032922Biological processcircadian regulation of gene expression
GO_0042632Biological processcholesterol homeostasis
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0050728Biological processnegative regulation of inflammatory response
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0021930Biological processcerebellar granule cell precursor proliferation
GO_0042753Biological processpositive regulation of circadian rhythm
GO_0006809Biological processnitric oxide biosynthetic process
GO_0006355Biological processregulation of DNA-templated transcription
GO_0010575Biological processpositive regulation of vascular endothelial growth factor production
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0004879Molecular functionnuclear receptor activity
GO_0001221Molecular functiontranscription coregulator binding
GO_0001222Molecular functiontranscription corepressor binding
GO_0008013Molecular functionbeta-catenin binding
GO_0001223Molecular functiontranscription coactivator binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008270Molecular functionzinc ion binding
GO_0008142Molecular functionoxysterol binding
GO_0005515Molecular functionprotein binding
GO_0098531Molecular functionligand-activated transcription factor activity

IV. Literature review

[source]
Gene nameRORA
Protein nameNuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha)
RAR related orphan receptor A (RAR-related orphan receptor A, isoform CRA_c)
RAR related orphan receptor A
SynonymsRZRA
hCG_1787044
NR1F1
DescriptionFUNCTION: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development . Regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC1 and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling. .

AccessionsENST00000559343.1
ENST00000261523.9 [P35398-1]
H0YLS5
ENST00000551975.5
A0A087X2G0
ENST00000558904.2
ENST00000335670.11 [P35398-2]
ENST00000449337.6
A0A0C4DFP5
A0A0C4DG53
H0YII6
P35398
ENST00000309157.8