ESR2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	7 studies	23% ± 3%	Explore
adipocyte	5 studies	21% ± 3%	Explore
GABAergic neuron	4 studies	32% ± 6%	Explore
glutamatergic neuron	4 studies	33% ± 2%	Explore
ciliated cell	4 studies	31% ± 9%	Explore
cardiac muscle cell	3 studies	20% ± 4%	Explore
retinal rod cell	3 studies	42% ± 8%	Explore
T cell	3 studies	20% ± 3%	Explore
endothelial cell of vascular tree	3 studies	37% ± 4%	Explore
astrocyte	3 studies	33% ± 15%	Explore
club cell	3 studies	21% ± 1%	Explore
type I pneumocyte	3 studies	25% ± 3%	Explore
basal cell	3 studies	32% ± 16%	Explore
interneuron	3 studies	38% ± 7%	Explore
plasma cell	3 studies	25% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
eye	4 studies	27% ± 7%	Explore
brain	3 studies	31% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	1003.58	258 / 258	18%	0.43	41 / 230
ovary	100%	972.89	180 / 180	9%	0.15	38 / 430
lung	98%	138.94	568 / 578	9%	0.17	108 / 1155
thymus	100%	146.93	650 / 653	8%	0.13	46 / 605
esophagus	85%	82.30	1230 / 1445	22%	0.35	40 / 183
kidney	100%	234.45	89 / 89	5%	0.13	48 / 901
uterus	99%	263.01	168 / 170	6%	0.09	28 / 459
prostate	99%	319.36	242 / 245	4%	0.07	21 / 502
breast	100%	183.63	457 / 459	1%	0.03	14 / 1118
spleen	100%	324.81	241 / 241	0%	0	0 / 0
pancreas	95%	251.25	311 / 328	5%	0.08	9 / 178
adipose	100%	200.47	1198 / 1204	0%	0	0 / 0
bladder	86%	196.00	18 / 21	10%	0.18	51 / 504
muscle	95%	171.91	766 / 803	0%	0	0 / 0
skin	72%	102.74	1302 / 1809	22%	0.65	103 / 472
stomach	81%	71.31	292 / 359	9%	0.17	27 / 286
peripheral blood	83%	195.71	767 / 929	0%	0	0 / 0
intestine	77%	113.71	741 / 966	5%	0.08	27 / 527
heart	76%	58.77	657 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	72%	3.14	21 / 29
liver	62%	78.32	139 / 226	1%	0.01	3 / 406
blood vessel	51%	32.65	682 / 1335	0%	0	0 / 0
brain	41%	36.40	1082 / 2642	5%	0.18	36 / 705
tonsil	0%	0	0 / 0	9%	0.18	4 / 45
eye	0%	0	0 / 0	5%	0.11	4 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0007165	Biological process	signal transduction
GO_0071391	Biological process	cellular response to estrogen stimulus
GO_0071392	Biological process	cellular response to estradiol stimulus
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0007267	Biological process	cell-cell signaling
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0030308	Biological process	negative regulation of cell growth
GO_0030520	Biological process	estrogen receptor signaling pathway
GO_0005739	Cellular component	mitochondrion
GO_0005654	Cellular component	nucleoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0019899	Molecular function	enzyme binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003707	Molecular function	nuclear steroid receptor activity
GO_0004879	Molecular function	nuclear receptor activity
GO_0034056	Molecular function	estrogen response element binding
GO_0008270	Molecular function	zinc ion binding
GO_0005496	Molecular function	steroid binding
GO_0048019	Molecular function	receptor antagonist activity
GO_0005515	Molecular function	protein binding
GO_0030284	Molecular function	nuclear estrogen receptor activity

IV. Literature review

[source]

Gene name	ESR2
Protein name	Estrogen receptor beta Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) Estrogen receptor beta (Nuclear receptor subfamily 3 group A member 2) Estrogen receptor beta splice variant, ERbetaEx. 4L
Synonyms	NR3A2 hCG_21449 ESTRB
Description	FUNCTION: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner . .; FUNCTION: [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. .
Accessions	ENST00000556275.5 Q92731 Q7LCB3 A0A679EN27 ENST00000554572.5 [Q92731-2] A0A348FV98 A0A348FV92 A0A348FV94 A0A348FV96 ENST00000344288.10 [Q92731-3] A0A348FV95 ENST00000555278.5 [Q92731-5] ENST00000267525.10 [Q92731-7] ENST00000353772.7 [Q92731-2] A0A348FV91 G3V5S2 A0A348FV97 ENST00000358599.9 [Q92731-2] ENST00000553796.5 [Q92731-9] ENST00000341099.6 [Q92731-1] ENST00000557772.5 [Q92731-6] A0A348FV93

ESR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review