PPARD | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	11 studies	31% ± 14%	Explore
microglial cell	11 studies	38% ± 13%	Explore
macrophage	11 studies	31% ± 20%	Explore
oligodendrocyte	6 studies	22% ± 5%	Explore
myeloid cell	6 studies	25% ± 4%	Explore
monocyte	4 studies	25% ± 9%	Explore
epithelial cell	3 studies	32% ± 14%	Explore
dendritic cell	3 studies	20% ± 1%	Explore
GABAergic neuron	3 studies	31% ± 7%	Explore
glutamatergic neuron	3 studies	43% ± 9%	Explore
oligodendrocyte precursor cell	3 studies	24% ± 6%	Explore
mast cell	3 studies	24% ± 3%	Explore
alveolar macrophage	3 studies	35% ± 10%	Explore
astrocyte	3 studies	25% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	32% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4561.64	1445 / 1445	100%	81.60	183 / 183
skin	100%	4835.22	1809 / 1809	100%	64.00	472 / 472
thymus	100%	7921.83	653 / 653	100%	78.08	605 / 605
brain	100%	3960.20	2639 / 2642	100%	66.72	705 / 705
intestine	100%	4258.41	966 / 966	100%	46.83	526 / 527
uterus	100%	3849.99	170 / 170	100%	61.48	458 / 459
ovary	100%	5405.01	180 / 180	100%	40.56	429 / 430
prostate	100%	5212.53	245 / 245	100%	38.65	500 / 502
stomach	100%	3926.63	359 / 359	99%	41.57	284 / 286
lung	100%	5391.88	577 / 578	99%	51.98	1148 / 1155
adrenal gland	100%	3300.04	258 / 258	99%	32.92	228 / 230
breast	100%	3441.27	459 / 459	99%	41.17	1106 / 1118
bladder	100%	4057.38	21 / 21	99%	54.84	497 / 504
kidney	100%	3244.88	89 / 89	98%	44.35	882 / 901
pancreas	88%	1162.59	290 / 328	98%	46.52	174 / 178
liver	98%	2896.86	222 / 226	87%	24.20	355 / 406
adipose	100%	3333.56	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	42.19	80 / 80
lymph node	0%	0	0 / 0	100%	29.67	29 / 29
spleen	100%	5308.27	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	63.64	45 / 45
ureter	0%	0	0 / 0	100%	72.78	1 / 1
blood vessel	100%	3153.30	1334 / 1335	0%	0	0 / 0
muscle	100%	2934.13	801 / 803	0%	0	0 / 0
heart	97%	2341.00	836 / 861	0%	0	0 / 0
peripheral blood	92%	1763.82	852 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0097009	Biological process	energy homeostasis
GO_0097190	Biological process	apoptotic signaling pathway
GO_0031589	Biological process	cell-substrate adhesion
GO_0006091	Biological process	generation of precursor metabolites and energy
GO_0008283	Biological process	cell population proliferation
GO_1904659	Biological process	glucose transmembrane transport
GO_0010887	Biological process	negative regulation of cholesterol storage
GO_0045923	Biological process	positive regulation of fatty acid metabolic process
GO_0046697	Biological process	decidualization
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0045662	Biological process	negative regulation of myoblast differentiation
GO_0070341	Biological process	fat cell proliferation
GO_0071456	Biological process	cellular response to hypoxia
GO_0010628	Biological process	positive regulation of gene expression
GO_0008203	Biological process	cholesterol metabolic process
GO_1902894	Biological process	negative regulation of miRNA transcription
GO_0051546	Biological process	keratinocyte migration
GO_0030522	Biological process	intracellular receptor signaling pathway
GO_0070346	Biological process	positive regulation of fat cell proliferation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006631	Biological process	fatty acid metabolic process
GO_0050680	Biological process	negative regulation of epithelial cell proliferation
GO_2000288	Biological process	positive regulation of myoblast proliferation
GO_0042060	Biological process	wound healing
GO_0015908	Biological process	fatty acid transport
GO_0031669	Biological process	cellular response to nutrient levels
GO_0050728	Biological process	negative regulation of inflammatory response
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0014842	Biological process	regulation of skeletal muscle satellite cell proliferation
GO_0030154	Biological process	cell differentiation
GO_0045600	Biological process	positive regulation of fat cell differentiation
GO_0043415	Biological process	positive regulation of skeletal muscle tissue regeneration
GO_0009062	Biological process	fatty acid catabolic process
GO_0008366	Biological process	axon ensheathment
GO_0043491	Biological process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0009755	Biological process	hormone-mediated signaling pathway
GO_0043401	Biological process	steroid hormone receptor signaling pathway
GO_0060612	Biological process	adipose tissue development
GO_0006915	Biological process	apoptotic process
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0006635	Biological process	fatty acid beta-oxidation
GO_0006629	Biological process	lipid metabolic process
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0006006	Biological process	glucose metabolic process
GO_0043616	Biological process	keratinocyte proliferation
GO_0007566	Biological process	embryo implantation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0008289	Molecular function	lipid binding
GO_0003707	Molecular function	nuclear steroid receptor activity
GO_0004879	Molecular function	nuclear receptor activity
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0070539	Molecular function	linoleic acid binding
GO_0001223	Molecular function	transcription coactivator binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0008270	Molecular function	zinc ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PPARD
Protein name	Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta) Peroxisome proliferative activated receptor, delta, isoform CRA_b (Peroxisome proliferator-activated nuclear receptor beta/delta variant 2) Alternative protein PPARD
Synonyms	NR1C2 PPARB hCG_17666
Description	FUNCTION: Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues . Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. .
Accessions	L8EBG7 ENST00000448077.6 [Q03181-3] F1D8S7 Q03181 ENST00000360694.8 [Q03181-1] ENST00000311565.4 [Q03181-1] ENST00000418635.6 [Q03181-4] ENST00000337400.6 [Q03181-2]

PPARD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review