PPARA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032099Biological processnegative regulation of appetite
GO_0007584Biological processresponse to nutrient
GO_0008544Biological processepidermis development
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_2000272Biological processnegative regulation of signaling receptor activity
GO_0007507Biological processheart development
GO_0010887Biological processnegative regulation of cholesterol storage
GO_0032000Biological processpositive regulation of fatty acid beta-oxidation
GO_0045923Biological processpositive regulation of fatty acid metabolic process
GO_1902894Biological processnegative regulation of miRNA transcription
GO_0032868Biological processresponse to insulin
GO_0030522Biological processintracellular receptor signaling pathway
GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_0019217Biological processregulation of fatty acid metabolic process
GO_0035095Biological processbehavioral response to nicotine
GO_0046889Biological processpositive regulation of lipid biosynthetic process
GO_1904189Biological processpositive regulation of transformation of host cell by virus
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0009267Biological processcellular response to starvation
GO_0010891Biological processnegative regulation of sequestering of triglyceride
GO_0006631Biological processfatty acid metabolic process
GO_0045471Biological processresponse to ethanol
GO_0046321Biological processpositive regulation of fatty acid oxidation
GO_0032922Biological processcircadian regulation of gene expression
GO_0042752Biological processregulation of circadian rhythm
GO_1903427Biological processnegative regulation of reactive oxygen species biosynthetic process
GO_0042157Biological processlipoprotein metabolic process
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0061052Biological processnegative regulation of cell growth involved in cardiac muscle cell development
GO_0042060Biological processwound healing
GO_0045820Biological processnegative regulation of glycolytic process
GO_0010745Biological processnegative regulation of macrophage derived foam cell differentiation
GO_0045722Biological processpositive regulation of gluconeogenesis
GO_0050728Biological processnegative regulation of inflammatory response
GO_0045776Biological processnegative regulation of blood pressure
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_2000191Biological processregulation of fatty acid transport
GO_0030154Biological processcell differentiation
GO_0001666Biological processresponse to hypoxia
GO_0006094Biological processgluconeogenesis
GO_1903944Biological processnegative regulation of hepatocyte apoptotic process
GO_0009755Biological processhormone-mediated signaling pathway
GO_0043401Biological processsteroid hormone receptor signaling pathway
GO_0010565Biological processregulation of cellular ketone metabolic process
GO_0070166Biological processenamel mineralization
GO_0046209Biological processnitric oxide metabolic process
GO_1903038Biological processnegative regulation of leukocyte cell-cell adhesion
GO_0071332Biological processcellular response to fructose stimulus
GO_2001171Biological processpositive regulation of ATP biosynthetic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0031624Molecular functionubiquitin conjugating enzyme binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0019904Molecular functionprotein domain specific binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0008289Molecular functionlipid binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003707Molecular functionnuclear steroid receptor activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0004879Molecular functionnuclear receptor activity
GO_0031435Molecular functionmitogen-activated protein kinase kinase kinase binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0097371Molecular functionMDM2/MDM4 family protein binding
GO_0001223Molecular functiontranscription coactivator binding
GO_0019902Molecular functionphosphatase binding
GO_0051525Molecular functionNFAT protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008270Molecular functionzinc ion binding
GO_0001216Molecular functionDNA-binding transcription activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePPARA
Protein namePeroxisome proliferator-activated receptor alpha
Alternative protein PPARA
Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)
SynonymsNR1C1
SC22CB-5E3.5-002
SC22CB-5E3.5-009
SC22CB-5E3.5-003
PPAR
DescriptionFUNCTION: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. .

AccessionsB0QYX1
L8E859
ENST00000440343.5
ENST00000420804.5
Q86SF0
ENST00000407236.6 [Q07869-1]
Q07869
B0QYX2
ENST00000415785.5
ENST00000402126.1 [Q07869-1]