Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 6 studies | 29% ± 12% | |
| enterocyte | 5 studies | 24% ± 3% | |
| hepatocyte | 5 studies | 54% ± 18% | |
| epithelial cell of proximal tubule | 4 studies | 22% ± 3% | |
| goblet cell | 3 studies | 22% ± 4% | |
| intestinal crypt stem cell | 3 studies | 22% ± 5% | |
| transit amplifying cell | 3 studies | 22% ± 4% |
Insufficient scRNA-seq data for expression of HNF4A at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 13955.38 | 226 / 226 | 99% | 104.31 | 400 / 406 |
| pancreas | 100% | 1560.52 | 328 / 328 | 83% | 29.00 | 147 / 178 |
| stomach | 78% | 1152.78 | 281 / 359 | 97% | 118.75 | 277 / 286 |
| kidney | 99% | 4486.64 | 88 / 89 | 74% | 30.71 | 663 / 901 |
| intestine | 70% | 5356.25 | 678 / 966 | 96% | 124.09 | 507 / 527 |
| esophagus | 1% | 4.74 | 17 / 1445 | 46% | 43.89 | 85 / 183 |
| bladder | 5% | 4.90 | 1 / 21 | 25% | 32.60 | 126 / 504 |
| lung | 8% | 7.05 | 47 / 578 | 16% | 9.33 | 190 / 1155 |
| adrenal gland | 12% | 10.87 | 31 / 258 | 1% | 0.47 | 3 / 230 |
| brain | 12% | 10.62 | 328 / 2642 | 0% | 0 | 0 / 705 |
| uterus | 2% | 4.74 | 4 / 170 | 7% | 2.56 | 31 / 459 |
| peripheral blood | 5% | 11.51 | 46 / 929 | 0% | 0 | 0 / 0 |
| ovary | 2% | 1.66 | 3 / 180 | 1% | 0.12 | 3 / 430 |
| breast | 2% | 23.84 | 9 / 459 | 0% | 0 | 0 / 1118 |
| adipose | 1% | 3.13 | 18 / 1204 | 0% | 0 | 0 / 0 |
| prostate | 1% | 1.33 | 2 / 245 | 0% | 0 | 0 / 502 |
| skin | 1% | 0.59 | 13 / 1809 | 0% | 0 | 0 / 472 |
| spleen | 0% | 12.42 | 1 / 241 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.41 | 3 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0.36 | 3 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 0% | 0.15 | 1 / 653 | 0% | 0 | 0 / 605 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0070328 | Biological process | triglyceride homeostasis |
| GO_0006366 | Biological process | transcription by RNA polymerase II |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0050796 | Biological process | regulation of insulin secretion |
| GO_0055091 | Biological process | phospholipid homeostasis |
| GO_0006805 | Biological process | xenobiotic metabolic process |
| GO_0009749 | Biological process | response to glucose |
| GO_0007548 | Biological process | sex differentiation |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0030522 | Biological process | intracellular receptor signaling pathway |
| GO_0019216 | Biological process | regulation of lipid metabolic process |
| GO_0010470 | Biological process | regulation of gastrulation |
| GO_0007596 | Biological process | blood coagulation |
| GO_0042752 | Biological process | regulation of circadian rhythm |
| GO_0042632 | Biological process | cholesterol homeostasis |
| GO_0023019 | Biological process | signal transduction involved in regulation of gene expression |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0030154 | Biological process | cell differentiation |
| GO_0006591 | Biological process | ornithine metabolic process |
| GO_0055088 | Biological process | lipid homeostasis |
| GO_0048856 | Biological process | anatomical structure development |
| GO_0006629 | Biological process | lipid metabolic process |
| GO_0048511 | Biological process | rhythmic process |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0042593 | Biological process | glucose homeostasis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0030308 | Biological process | negative regulation of cell growth |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_0004879 | Molecular function | nuclear receptor activity |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0005504 | Molecular function | fatty acid binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | HNF4A |
| Protein name | Hepatocyte nuclear factor 4 4 alpha variant 4 (Hepatocyte nuclear factor 4, alpha, isoform CRA_a) Hepatic nuclear factor 4 alpha Truncated hepatocyte nuclear factor 1 alpha HNF4alpha10/11/12 (Hepatocyte nuclear factor 4 alpha) Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) Hepatocyte nuclear factor 4 alpha |
| Synonyms | hCG_38107 TCF14 NR2A1 HNF4alpha HNF4 MODY3 |
| Description | FUNCTION: Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes . Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells . . |
| Accessions | A0A804HJJ6 ENST00000682169.1 ENST00000609262.5 B9VVT8 ENST00000457232.5 [P41235-6] A0A804HJ81 A0A804HI58 ENST00000443598.6 [P41235-3] ENST00000372920.1 A0A2R3XWA5 ENST00000684476.1 ENST00000316099.10 [P41235-1] A0A2R3XWF7 ENST00000681977.1 A0A804HJL7 ENST00000609795.5 [P41235-7] A0A2R3XWA6 ENST00000684136.1 ENST00000415691.2 [P41235-2] F8WBS7 A0A087WXV4 ENST00000316673.9 [P41235-5] A0A2R3XWC8 ENST00000682427.1 Q8NHY1 F1D8T0 A0A804HIR4 ENST00000684046.1 ENST00000619550.5 A0A804HJ41 P41235 |
