I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| Mueller cell | 3 studies | 26% ± 3% | |
| astrocyte | 3 studies | 28% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| Mueller cell | 3 studies | 26% ± 3% | |
| astrocyte | 3 studies | 28% ± 7% |
Insufficient scRNA-seq data for expression of NR2E1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 76% | 1462.39 | 2013 / 2642 | 98% | 15.94 | 688 / 705 |
| tonsil | 0% | 0 | 0 / 0 | 29% | 1.12 | 13 / 45 |
| eye | 0% | 0 | 0 / 0 | 29% | 2.79 | 23 / 80 |
| kidney | 0% | 0 | 0 / 89 | 16% | 1.35 | 144 / 901 |
| skin | 0% | 0 | 0 / 1809 | 16% | 0.88 | 75 / 472 |
| esophagus | 0% | 0 | 0 / 1445 | 14% | 0.64 | 26 / 183 |
| bladder | 0% | 0 | 0 / 21 | 10% | 0.25 | 51 / 504 |
| lung | 0% | 0 | 0 / 578 | 9% | 0.28 | 107 / 1155 |
| uterus | 0% | 0 | 0 / 170 | 9% | 0.37 | 41 / 459 |
| prostate | 0% | 0 | 0 / 245 | 6% | 0.25 | 30 / 502 |
| stomach | 0% | 0 | 0 / 359 | 2% | 0.06 | 7 / 286 |
| breast | 0% | 0 | 0 / 459 | 2% | 0.21 | 25 / 1118 |
| thymus | 0% | 0 | 0 / 653 | 2% | 0.09 | 13 / 605 |
| adrenal gland | 1% | 2.17 | 3 / 258 | 1% | 0.02 | 2 / 230 |
| intestine | 0% | 0 | 0 / 966 | 2% | 0.04 | 9 / 527 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.02 | 5 / 406 |
| peripheral blood | 1% | 3.08 | 11 / 929 | 0% | 0 | 0 / 0 |
| pancreas | 0% | 0 | 0 / 328 | 1% | 0.01 | 1 / 178 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0 | 0 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0 | 0 / 1335 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ovary | 0% | 0 | 0 / 180 | 0% | 0 | 0 / 430 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0043615 | Biological process | astrocyte cell migration |
| GO_0002052 | Biological process | positive regulation of neuroblast proliferation |
| GO_0007601 | Biological process | visual perception |
| GO_0060164 | Biological process | regulation of timing of neuron differentiation |
| GO_0001525 | Biological process | angiogenesis |
| GO_0021764 | Biological process | amygdala development |
| GO_0048814 | Biological process | regulation of dendrite morphogenesis |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0021872 | Biological process | forebrain generation of neurons |
| GO_0002118 | Biological process | aggressive behavior |
| GO_0021542 | Biological process | dentate gyrus development |
| GO_0030198 | Biological process | extracellular matrix organization |
| GO_0030522 | Biological process | intracellular receptor signaling pathway |
| GO_2000648 | Biological process | positive regulation of stem cell proliferation |
| GO_0021819 | Biological process | layer formation in cerebral cortex |
| GO_0060041 | Biological process | retina development in camera-type eye |
| GO_0048712 | Biological process | negative regulation of astrocyte differentiation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0060291 | Biological process | long-term synaptic potentiation |
| GO_0048708 | Biological process | astrocyte differentiation |
| GO_0021772 | Biological process | olfactory bulb development |
| GO_0045665 | Biological process | negative regulation of neuron differentiation |
| GO_0021960 | Biological process | anterior commissure morphogenesis |
| GO_0045165 | Biological process | cell fate commitment |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0030154 | Biological process | cell differentiation |
| GO_0090049 | Biological process | regulation of cell migration involved in sprouting angiogenesis |
| GO_0043401 | Biological process | steroid hormone receptor signaling pathway |
| GO_0001662 | Biological process | behavioral fear response |
| GO_0006915 | Biological process | apoptotic process |
| GO_0048856 | Biological process | anatomical structure development |
| GO_0021895 | Biological process | cerebral cortex neuron differentiation |
| GO_0035176 | Biological process | social behavior |
| GO_0035019 | Biological process | somatic stem cell population maintenance |
| GO_0007399 | Biological process | nervous system development |
| GO_2000178 | Biological process | negative regulation of neural precursor cell proliferation |
| GO_0045787 | Biological process | positive regulation of cell cycle |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0007405 | Biological process | neuroblast proliferation |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0001227 | Molecular function | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0003707 | Molecular function | nuclear steroid receptor activity |
| GO_0004879 | Molecular function | nuclear receptor activity |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0042826 | Molecular function | histone deacetylase binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NR2E1 |
| Protein name | Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) (hTll) Nuclear receptor subfamily 2 group E member 1 Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) |
| Synonyms | hCG_34018 TLX |
| Description | FUNCTION: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells. . |
| Accessions | ENST00000368986.9 [Q9Y466-1] A6PVF6 B6ZGT9 ENST00000368983.3 [Q9Y466-2] ENST00000426403.1 Q9Y466 |
