Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 11 studies | 36% ± 17% | |
| hepatocyte | 4 studies | 62% ± 31% | |
| endothelial cell of sinusoid | 3 studies | 35% ± 14% | |
| endothelial cell of vascular tree | 3 studies | 31% ± 12% | |
| cholangiocyte | 3 studies | 68% ± 15% | |
| epithelial cell | 3 studies | 22% ± 5% | |
| endothelial cell of lymphatic vessel | 3 studies | 27% ± 4% |
Insufficient scRNA-seq data for expression of NR5A2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 2434.58 | 226 / 226 | 97% | 20.78 | 393 / 406 |
| pancreas | 100% | 6283.53 | 328 / 328 | 91% | 10.33 | 162 / 178 |
| intestine | 85% | 1078.47 | 822 / 966 | 91% | 5.54 | 479 / 527 |
| prostate | 97% | 396.02 | 238 / 245 | 76% | 2.45 | 383 / 502 |
| breast | 100% | 932.94 | 459 / 459 | 71% | 1.95 | 789 / 1118 |
| lung | 95% | 542.00 | 551 / 578 | 55% | 1.76 | 636 / 1155 |
| stomach | 48% | 103.44 | 174 / 359 | 92% | 6.27 | 263 / 286 |
| uterus | 99% | 793.54 | 168 / 170 | 38% | 1.78 | 174 / 459 |
| bladder | 86% | 297.43 | 18 / 21 | 42% | 1.57 | 211 / 504 |
| esophagus | 69% | 160.06 | 994 / 1445 | 55% | 4.97 | 101 / 183 |
| thymus | 84% | 240.87 | 550 / 653 | 37% | 0.80 | 224 / 605 |
| adipose | 100% | 1071.78 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| skin | 54% | 134.74 | 969 / 1809 | 41% | 1.20 | 192 / 472 |
| ovary | 69% | 219.40 | 124 / 180 | 21% | 0.86 | 91 / 430 |
| kidney | 27% | 53.62 | 24 / 89 | 57% | 2.47 | 516 / 901 |
| lymph node | 0% | 0 | 0 / 0 | 55% | 0.97 | 16 / 29 |
| blood vessel | 43% | 131.01 | 573 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 9% | 15.79 | 22 / 258 | 27% | 0.60 | 62 / 230 |
| brain | 2% | 7.74 | 66 / 2642 | 31% | 0.61 | 220 / 705 |
| muscle | 33% | 62.97 | 262 / 803 | 0% | 0 | 0 / 0 |
| heart | 28% | 53.39 | 237 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 24% | 1.51 | 11 / 45 |
| spleen | 1% | 2.98 | 2 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.55 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0008206 | Biological process | bile acid metabolic process |
| GO_0009888 | Biological process | tissue development |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_1990830 | Biological process | cellular response to leukemia inhibitory factor |
| GO_0030522 | Biological process | intracellular receptor signaling pathway |
| GO_0009792 | Biological process | embryo development ending in birth or egg hatching |
| GO_0045070 | Biological process | positive regulation of viral genome replication |
| GO_0042632 | Biological process | cholesterol homeostasis |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0061113 | Biological process | pancreas morphogenesis |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0009755 | Biological process | hormone-mediated signaling pathway |
| GO_0090425 | Biological process | acinar cell differentiation |
| GO_0042592 | Biological process | homeostatic process |
| GO_0097720 | Biological process | calcineurin-mediated signaling |
| GO_0042127 | Biological process | regulation of cell population proliferation |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0090575 | Cellular component | RNA polymerase II transcription regulator complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0005543 | Molecular function | phospholipid binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_0004879 | Molecular function | nuclear receptor activity |
| GO_0001221 | Molecular function | transcription coregulator binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NR5A2 |
| Protein name | Hepatocytic transcription factor hB1F-3 (Nuclear receptor subfamily 5, group A, member 2, isoform CRA_c) Nuclear receptor subfamily 5, group A Nuclear receptor subfamily 5 group A member 2 Nuclear receptor NR5A2 Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1) Liver nuclear receptor homolog-1 variant 2 |
| Synonyms | B1F3 hCG_19256 B1F FTF CPF |
| Description | FUNCTION: Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex . May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38 (By similarity). .; FUNCTION: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with HNF1A to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). . |
| Accessions | ENST00000236914.7 [O00482-2] ENST00000367362.8 [O00482-1] H0Y328 Q9Y5V6 ENST00000447034.1 O00482 ENST00000474307.1 Q8WY08 F1D8R9 ENST00000367357.3 H0Y7S7 E9PQH2 B6ZGU9 ENST00000544748.5 [O00482-4] B3GPJ3 |
