SREBF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007584Biological processresponse to nutrient
GO_1901524Biological processregulation of mitophagy
GO_0030324Biological processlung development
GO_1903214Biological processregulation of protein targeting to mitochondrion
GO_0009749Biological processresponse to glucose
GO_0003062Biological processregulation of heart rate by chemical signal
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0030522Biological processintracellular receptor signaling pathway
GO_0019217Biological processregulation of fatty acid metabolic process
GO_0033762Biological processresponse to glucagon
GO_0008610Biological processlipid biosynthetic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0009267Biological processcellular response to starvation
GO_0010867Biological processpositive regulation of triglyceride biosynthetic process
GO_0045471Biological processresponse to ethanol
GO_0046676Biological processnegative regulation of insulin secretion
GO_0007623Biological processcircadian rhythm
GO_0090209Biological processnegative regulation of triglyceride metabolic process
GO_0009750Biological processresponse to fructose
GO_0051591Biological processresponse to cAMP
GO_0008286Biological processinsulin receptor signaling pathway
GO_0032933Biological processSREBP signaling pathway
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0010883Biological processregulation of lipid storage
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0030073Biological processinsulin secretion
GO_0032526Biological processresponse to retinoic acid
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0032094Biological processresponse to food
GO_0006629Biological processlipid metabolic process
GO_0006695Biological processcholesterol biosynthetic process
GO_0032570Biological processresponse to progesterone
GO_0045542Biological processpositive regulation of cholesterol biosynthetic process
GO_0031647Biological processregulation of protein stability
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071398Biological processcellular response to fatty acid
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005654Cellular componentnucleoplasm
GO_0005635Cellular componentnuclear envelope
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0012507Cellular componentER to Golgi transport vesicle membrane
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding
GO_0004879Molecular functionnuclear receptor activity
GO_0001221Molecular functiontranscription coregulator binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0019901Molecular functionprotein kinase binding
GO_0032810Molecular functionsterol response element binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSREBF1
Protein nameSterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)]
Sterol regulatory element-binding protein 1 (Sterol regulatory element-binding transcription factor 1)
Sterol regulatory element binding transcription factor 1
SynonymsBHLHD1
SREBP1
DescriptionFUNCTION: [Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane . Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity). .; FUNCTION: [Processed sterol regulatory element-binding protein 1]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis . Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') . Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation . .; FUNCTION: [Isoform SREBP-1A]: Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity). Able to stimulate both lipogenic and cholesterogenic gene expression . Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (By similarity). Required for innate immune response in macrophages by regulating lipid metabolism (By similarity). .; FUNCTION: [Isoform SREBP-1C]: Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity). Primarily controls expression of lipogenic gene . Strongly activates global lipid synthesis in rapidly growing cells (By similarity). .; FUNCTION: [Isoform SREBP-1aDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. .; FUNCTION: [Isoform SREBP-1cDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. .

AccessionsK7EMD1
K7EKR7
ENST00000577897.2
K7EMT8
ENST00000485080.6
ENST00000486311.5
ENST00000395757.6 [P36956-2]
ENST00000478616.1
J3QLB6
K7EIW8
ENST00000261646.11 [P36956-1]
ENST00000578469.1
ENST00000423161.3
P36956
ENST00000395756.5
F6V242
S4R3B4
ENST00000355815.8 [P36956-4]