PPARG | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	13 studies	30% ± 12%	Explore
macrophage	12 studies	28% ± 9%	Explore
adipocyte	11 studies	79% ± 19%	Explore
alveolar macrophage	8 studies	60% ± 18%	Explore
endothelial cell of lymphatic vessel	8 studies	36% ± 14%	Explore
pericyte	7 studies	31% ± 21%	Explore
epithelial cell	7 studies	25% ± 6%	Explore
microglial cell	6 studies	23% ± 8%	Explore
GABAergic neuron	5 studies	37% ± 14%	Explore
monocyte	5 studies	44% ± 28%	Explore
myeloid cell	4 studies	24% ± 5%	Explore
endothelial cell of vascular tree	4 studies	37% ± 18%	Explore
glutamatergic neuron	4 studies	38% ± 7%	Explore
interneuron	4 studies	34% ± 6%	Explore
extravillous trophoblast	3 studies	39% ± 13%	Explore
smooth muscle cell	3 studies	27% ± 8%	Explore

Name	Number of supported studies	Average coverage
lung	4 studies	21% ± 3%	Explore
brain	4 studies	32% ± 8%	Explore
placenta	3 studies	21% ± 2%	Explore
adipose	3 studies	48% ± 26%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	1108.53	89 / 89	98%	18.54	886 / 901
bladder	95%	2269.76	20 / 21	91%	76.11	460 / 504
stomach	88%	1121.28	316 / 359	96%	35.23	275 / 286
intestine	86%	1508.13	831 / 966	98%	42.69	514 / 527
lung	99%	1601.59	572 / 578	78%	13.00	901 / 1155
breast	100%	7183.42	459 / 459	59%	6.46	655 / 1118
thymus	100%	1355.95	651 / 653	50%	6.38	303 / 605
liver	62%	346.70	139 / 226	85%	12.04	346 / 406
uterus	91%	688.99	155 / 170	39%	11.74	177 / 459
esophagus	53%	311.38	773 / 1445	63%	15.39	115 / 183
ovary	99%	1257.66	178 / 180	11%	0.99	47 / 430
adipose	100%	9779.57	1204 / 1204	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	107.21	1 / 1
spleen	100%	947.99	240 / 241	0%	0	0 / 0
pancreas	3%	16.14	10 / 328	95%	43.64	169 / 178
prostate	64%	459.46	158 / 245	29%	2.68	144 / 502
skin	72%	867.41	1302 / 1809	21%	1.59	98 / 472
heart	90%	661.92	773 / 861	0%	0	0 / 0
adrenal gland	33%	182.74	86 / 258	30%	2.58	69 / 230
blood vessel	51%	553.21	677 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	48%	7.62	38 / 80
muscle	24%	123.19	193 / 803	0%	0	0 / 0
peripheral blood	20%	109.03	188 / 929	0%	0	0 / 0
brain	10%	43.80	254 / 2642	10%	0.62	69 / 705
tonsil	0%	0	0 / 0	18%	1.26	8 / 45
lymph node	0%	0	0 / 0	7%	0.30	2 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007584	Biological process	response to nutrient
GO_0010742	Biological process	macrophage derived foam cell differentiation
GO_1905563	Biological process	negative regulation of vascular endothelial cell proliferation
GO_1903845	Biological process	negative regulation of cellular response to transforming growth factor beta stimulus
GO_0030514	Biological process	negative regulation of BMP signaling pathway
GO_0043537	Biological process	negative regulation of blood vessel endothelial cell migration
GO_0030509	Biological process	BMP signaling pathway
GO_0050728	Biological process	negative regulation of inflammatory response
GO_1902895	Biological process	positive regulation of miRNA transcription
GO_0042789	Biological process	mRNA transcription by RNA polymerase II
GO_0043407	Biological process	negative regulation of MAP kinase activity
GO_0055088	Biological process	lipid homeostasis
GO_0048384	Biological process	retinoic acid receptor signaling pathway
GO_0048511	Biological process	rhythmic process
GO_0030224	Biological process	monocyte differentiation
GO_0050872	Biological process	white fat cell differentiation
GO_0035357	Biological process	peroxisome proliferator activated receptor signaling pathway
GO_0006919	Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0010629	Biological process	negative regulation of gene expression
GO_0030855	Biological process	epithelial cell differentiation
GO_0045087	Biological process	innate immune response
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0007165	Biological process	signal transduction
GO_0008217	Biological process	regulation of blood pressure
GO_0010628	Biological process	positive regulation of gene expression
GO_1902894	Biological process	negative regulation of miRNA transcription
GO_1901202	Biological process	negative regulation of extracellular matrix assembly
GO_0006631	Biological process	fatty acid metabolic process
GO_0042752	Biological process	regulation of circadian rhythm
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_1904893	Biological process	negative regulation of receptor signaling pathway via STAT
GO_0033993	Biological process	response to lipid
GO_0045165	Biological process	cell fate commitment
GO_0042953	Biological process	lipoprotein transport
GO_0090258	Biological process	negative regulation of mitochondrial fission
GO_0006629	Biological process	lipid metabolic process
GO_1904179	Biological process	positive regulation of adipose tissue development
GO_0060392	Biological process	negative regulation of SMAD protein signal transduction
GO_0032869	Biological process	cellular response to insulin stimulus
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_2000272	Biological process	negative regulation of signaling receptor activity
GO_0045923	Biological process	positive regulation of fatty acid metabolic process
GO_0015909	Biological process	long-chain fatty acid transport
GO_0060336	Biological process	negative regulation of type II interferon-mediated signaling pathway
GO_0010891	Biological process	negative regulation of sequestering of triglyceride
GO_0070165	Biological process	positive regulation of adiponectin secretion
GO_0010745	Biological process	negative regulation of macrophage derived foam cell differentiation
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0045668	Biological process	negative regulation of osteoblast differentiation
GO_0010888	Biological process	negative regulation of lipid storage
GO_1900076	Biological process	regulation of cellular response to insulin stimulus
GO_0048469	Biological process	cell maturation
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_1905599	Biological process	positive regulation of low-density lipoprotein receptor activity
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_1905461	Biological process	positive regulation of vascular associated smooth muscle cell apoptotic process
GO_1903243	Biological process	negative regulation of cardiac muscle hypertrophy in response to stress
GO_0030512	Biological process	negative regulation of transforming growth factor beta receptor signaling pathway
GO_0010887	Biological process	negative regulation of cholesterol storage
GO_1904706	Biological process	negative regulation of vascular associated smooth muscle cell proliferation
GO_0060694	Biological process	regulation of cholesterol transporter activity
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_1904597	Biological process	negative regulation of connective tissue replacement involved in inflammatory response wound healing
GO_0001890	Biological process	placenta development
GO_0016525	Biological process	negative regulation of angiogenesis
GO_0071404	Biological process	cellular response to low-density lipoprotein particle stimulus
GO_0030154	Biological process	cell differentiation
GO_0045600	Biological process	positive regulation of fat cell differentiation
GO_0048662	Biological process	negative regulation of smooth muscle cell proliferation
GO_0010875	Biological process	positive regulation of cholesterol efflux
GO_0009755	Biological process	hormone-mediated signaling pathway
GO_0042593	Biological process	glucose homeostasis
GO_0071456	Biological process	cellular response to hypoxia
GO_0005634	Cellular component	nucleus
GO_0005654	Cellular component	nucleoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0043235	Cellular component	receptor complex
GO_0090575	Cellular component	RNA polymerase II transcription regulator complex
GO_0000785	Cellular component	chromatin
GO_0005829	Cellular component	cytosol
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0042802	Molecular function	identical protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0070888	Molecular function	E-box binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043565	Molecular function	sequence-specific DNA binding
GO_0003682	Molecular function	chromatin binding
GO_0003690	Molecular function	double-stranded DNA binding
GO_0050544	Molecular function	arachidonic acid binding
GO_0019899	Molecular function	enzyme binding
GO_0050693	Molecular function	LBD domain binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0042277	Molecular function	peptide binding
GO_0004879	Molecular function	nuclear receptor activity
GO_0001221	Molecular function	transcription coregulator binding
GO_0050692	Molecular function	DNA binding domain binding
GO_0051393	Molecular function	alpha-actinin binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding
GO_0003677	Molecular function	DNA binding
GO_0070412	Molecular function	R-SMAD binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003676	Molecular function	nucleic acid binding
GO_0097677	Molecular function	STAT family protein binding
GO_0046965	Molecular function	nuclear retinoid X receptor binding
GO_0004955	Molecular function	prostaglandin receptor activity

IV. Literature review

[source]

Gene name	PPARG
Protein name	Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) Peroxisome proliferator activated receptor gamma
Synonyms	PPARG3D5 gamma PPARG5 PPARG1D5 NR1C3 hCG_26772 PPAR PPARG2D5
Description	FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (By similarity). .; FUNCTION: (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. . FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. .
Accessions	A0A494C0D9 A0A804HJN2 A0A804HIG1 ENST00000397026.7 ENST00000396999.3 A0A804HLH1 ENST00000455517.6 B6ZGS2 Q4W4C7 A0A494C0T3 ENST00000397029.8 E9PFV3 Q53EW1 ENST00000682446.1 ENST00000652098.1 ENST00000643888.2 A0A804HL89 P37231 ENST00000684065.1 ENST00000287820.10 [P37231-1] ENST00000683699.1 D2KUA6 ENST00000309576.11 ENST00000681966.1 E7EU07 ENST00000397015.7 ENST00000683749.1 Q6L9M1 ENST00000397010.7 A0A494C1F9 ENST00000438682.6 Q4W4C6 E7EUD1 ENST00000652431.1 E9PFX5 E9PFV2 ENST00000643197.2 ENST00000683586.1 ENST00000651735.1 A0A499FIV4 ENST00000397023.5 ENST00000683700.1 Q86WD1 ENST00000397000.6 A0A494C012 A0A0S2Z4K5 ENST00000681982.1 ENST00000652522.1 ENST00000644622.2 A0A3P3ZKM0

PPARG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review