PGR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002071Biological processglandular epithelial cell maturation
GO_0048286Biological processlung alveolus development
GO_0001542Biological processovulation from ovarian follicle
GO_0010629Biological processnegative regulation of gene expression
GO_0030518Biological processnuclear receptor-mediated steroid hormone signaling pathway
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_0038001Biological processparacrine signaling
GO_0050847Biological processprogesterone receptor signaling pathway
GO_0007267Biological processcell-cell signaling
GO_0060748Biological processtertiary branching involved in mammary gland duct morphogenesis
GO_0042326Biological processnegative regulation of phosphorylation
GO_0051457Biological processmaintenance of protein location in nucleus
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0050678Biological processregulation of epithelial cell proliferation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005741Cellular componentmitochondrial outer membrane
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0019899Molecular functionenzyme binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003707Molecular functionnuclear steroid receptor activity
GO_0004879Molecular functionnuclear receptor activity
GO_0034056Molecular functionestrogen response element binding
GO_0042802Molecular functionidentical protein binding
GO_0001223Molecular functiontranscription coactivator binding
GO_0008270Molecular functionzinc ion binding
GO_0005496Molecular functionsteroid binding
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePGR
Protein nameProgesterone receptor
Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)
SynonymshCG_39657
PR
NR3C3
DescriptionFUNCTION: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. .; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. .; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. .; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

FUNCTION: Steroid hormone receptor involved in the regulation of eukaryotic gene expression which affects cellular proliferation and differentiation in target tissues. .

FUNCTION: Steroid hormone receptor involved in the regulation of eukaryotic gene expression which affects cellular proliferation and differentiation in target tissues. .

FUNCTION: Steroid hormone receptor involved in the regulation of eukaryotic gene expression which affects cellular proliferation and differentiation in target tissues. .

AccessionsP06401
Q8NG44
ENST00000534013.5 [P06401-3]
ENST00000263463.9 [P06401-5]
ENST00000619228.2
Q8NG45
ENST00000526300.5
ENST00000534780.5
A0A0J9YVP1
A0A4P8D7F0
ENST00000528960.5
Q8NG42
ENST00000632634.1
ENST00000325455.10 [P06401-1]